GIL ALTEROVITZ

Gil Alterovitz, Ph.D.

Assistant Professor, Harvard Medical School
Research Affiliate, MIT Computer Science and Artificial Intelligence Laboratory

Harvard Medical School and Massachusetts Institute of Technology

Phone: (617) 525-4478

Email:  gilusa@gmail.com

News
B. Toner, “MIT/Harvard’s Alterovitz on Biomarker Analysis, Complex Networks, and the Benefits of Commercial Software,” in Bioinform. vol. 10, Aug 18, 2006.J. Healey, “Massachusetts Institute of Technology Integrates Cancer Research in the Lab and
Classroom with MathWorks Tools,” in The Mathworks: User Stories, March 2006. [Full Text Web Link] [PDF Download from Mathworks Site]
Profile
Faculty, Children’s Hospital Informatics Program Member, Partners HealthCare Center for Personalized Genetic Medicine
Projects
Proteomics and Cellular Network Engineering:GO PaD
The Massome
Discovering Biological Guilds
OBOES
Raspap 
Teaching
Proteomics and Cellular Network Engineering: From Signal Processing to Stochastic Design (Bio.95hfa), Department of Molecular and Cellular Biology, Harvard University, Fall 2006/Spring 07 (New class- course materials developed).
Biomedical Computing (MIT 6.872 / HST 950), Harvard/MIT HST and MIT EECS.
Selected publications
  1. Warner JL, Zollanvari A, Ding Q, Zhang P, Snyder GM, Alterovitz G: Temporal Phenome Analysis of a Large Electronic Health Record Cohort Enables Identification of Hospital-Acquired Complications. AMIA 2013 2013 (Accepted).
  2. Warner JL, Alterovitz G, Bodio K, Joyce RM: External phenome analysis enables a rational federated query strategy to detect changing rates of treatment-related complications associated with multiple myeloma. Journal of the American Medical Informatics Association : JAMIA 2013, 20(4):696-699.
  3. Ting C, Alterovitz G, Merlob A, Abdi R: Genomic studies of GVHD-lessons learned thus far. Bone marrow transplantation 2013, 48(1):4-9.
  4. Sonis S, Antin J, Tedaldi M, Alterovitz G: SNP-based Bayesian networks can predict oral mucositis risk in autologous stem cell transplant recipients. Oral diseases 2013.
  5. Yu YH, Chiou GY, Huang PI, Lo WL, Wang CY, Lu KH, Yu CC, Alterovitz G, Huang WC, Lo JF et al: Network biology of tumor stem-like cells identified a regulatory role of CBX5 in lung cancer. Scientific reports 2012, 2:584.
  6. Quo C, Kaddi C, Phan J, Zollanvari A, Wang M, Alterovitz G: Reverse Engineering Bio-molecular Systems (REBMS) Using -Omic Data: Challenges, Progress, and Opportunities. Briefings in bioinformatics 2012.
  7. Warner J, Alterovitz G: Phenome-Based Analysis as a Means for Discovering Context-Dependent Clinical Reference Ranges. AMIA Annual Symposium proceedings / AMIA Symposium AMIA Symposium 2012.
  8. Ting C, Alterovitz G, Merlob A, Abdi R: Genomic studies of GVHD-lessons learned thus far. Bone marrow transplantation 2012.
  9. Parikh N, Zollanvari A, Alterovitz G: An automated bayesian framework for integrative gene expression analysis and predictive medicine. AMIA Summits on Translational Science proceedings AMIA Summit on Translational Science 2012, 2012:95-104.
  10. Marwah K, Katzin D, Zollanvari A, Noy NF, Ramoni M, Alterovitz G: Context-specific ontology integration: a bayesian approach. AMIA Summits on Translational Science proceedings AMIA Summit on Translational Science 2012, 2012:79-86.
  11. Deng M, Zollanvari A, Alterovitz G: A bayesian translational framework for knowledge propagation, discovery, and integration under specific contexts. AMIA Summits on Translational Science proceedings AMIA Summit on Translational Science 2012, 2012:25-34.
  12. Zollanvari A, Saccone NL, Bierut LJ, Ramoni MF, Alterovitz G: Is the reduction of dimensionality to a small number of features always necessary in constructing predictive models for analysis of complex diseases or behaviours? Conference proceedings : Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Conference 2011, 2011:3573-3576.
  13. Hartwig S, Ho J, Pandey P, Macisaac K, Taglienti M, Xiang M, Alterovitz G, Ramoni M, Fraenkel E, Kreidberg JA: Genomic characterization of Wilms’ tumor suppressor 1 targets in nephron progenitor cells during kidney development. Development 2010, 137(7):1189-1203.
  14. Chang HH, McGeachie M, Alterovitz G, Ramoni MF: Mapping transcription mechanisms from multimodal genomic data. BMC bioinformatics 2010, 11 Suppl 9:S2.
  15. Alterovitz G, Xiang M, Hill DP, Lomax J, Liu J, Cherkassky M, Dreyfuss J, Mungall C, Harris MA, Dolan ME et al: Ontology engineering. Nature biotechnology 2010, 28(2):128-130.
  16. Alterovitz G, Muso T, Ramoni MF: The challenges of informatics in synthetic biology: from biomolecular networks to artificial organisms. Briefings in bioinformatics 2010, 11(1):80-95.
  17. Maron JL, Alterovitz G, Ramoni M, Johnson KL, Bianchi DW: High-throughput discovery and characterization of fetal protein trafficking in the blood of pregnant women. Proteomics Clinical applications 2009, 3(12):1389-1396.
  18. Celi LA, Hinske LC, Alterovitz G, Szolovits P: An artificial intelligence tool to predict fluid requirement in the intensive care unit: a proof-of-concept study. Critical care 2008, 12(6):R151.
  19. Alterovitz G, Xiang M, Liu J, Chang A, Ramoni MF: System-wide peripheral biomarker discovery using information theory. Pacific Symposium on Biocomputing Pacific Symposium on Biocomputing 2008:231-242.
  20. Alterovitz G, Jiwaji A, Ramoni MF: Automated programming for bioinformatics algorithm deployment. Bioinformatics 2008, 24(3):450-451.
  21. Aivado M, Spentzos D, Germing U, Alterovitz G, Meng XY, Grall F, Giagounidis AA, Klement G, Steidl U, Otu HH et al: Serum proteome profiling detects myelodysplastic syndromes and identifies CXC chemokine ligands 4 and 7 as markers for advanced disease. Proceedings of the National Academy of Sciences of the United States of America 2007, 104(4):1307-1312.
  22. Alterovitz G, Liu J, Afkhami E, Ramoni MF: Bayesian methods for proteomics. Proteomics 2007, 7(16):2843-2855.
  23. Alterovitz G, Lyashenko E, Xiang M, Ramoni MF: Linking Protein Mass with Function via Organismal Massome Networks. Proceedings of the IEEE 7th International Symposium on Bioinformatics and Bioengineering (BIBE) 2007:59-65.
  24. Alterovitz G, Muso T, Malalur P, Ramoni MF: A Systematic Approach to Quantifying Evolutionary Functional Trends Across the Universal Tree of Life. Proceedings of the IEEE 7th International Symposium on Bioinformatics and Bioengineering (BIBE) 2007:374-378.
  25. Alterovitz G, Xiang M, Mohan M, Ramoni MF: GO PaD: the Gene Ontology Partition Database. Nucleic acids research 2007, 35(Database issue):D322-327.
  26. Maron JL, Johnson KL, Slonim D, Lai CQ, Ramoni M, Alterovitz G, Jarrah Z, Yang Z, Bianchi DW:Gene expression analysis in pregnant women and their infants identifies unique fetal biomarkersthat circulate in maternal blood. The Journal of clinical investigation 2007, 117(10):3007-3019.
  27. Alterovitz G, Ramoni MF: Biological Network Epitomes via Topological Compression. Proceedingsof IEEE Genomic Signal Processing and Statistics (GENSIPS) 2006.
  28. Alterovitz G, Ramoni MF: Discovering biological guilds through topological abstraction. AMIAAnnual Symposium proceedings / AMIA Symposium AMIA Symposium 2006:1-5.
  29. Alterovitz G, Muralidhar V, Ramoni MF: Gene Lethality Detection Across Biological Network Domains: Hubs Versus Stochastic Global Topological Analysis. Proceedings of IEEE Genomic Signal Processing and Statistics (GENSIPS) 2006.
  30. Alterovitz G, Liu J, Chow J, Ramoni MF: Automation, parallelism, and robotics for proteomics. Proteomics 2006, 6(14):4016-4022.
  31. Alterovitz G, Patek D, Kohane IS, Ramoni M: Human Protein Meta-Interaction Database (HPMD) Potentiates Integration for Meta-Analysis. Proceedings of IEEE Genomic Signal Processing and Statistics (GENSIPS) 2005.
  32. Alterovitz G, Kohane IS, Ramoni M: Characterizing Human Protein Mass Density Distributions. Proceedings of IEEE Genomic Signal Processing and Statistics (GENSIPS) 2005.
  33. Aivado M, Spentzos D, Alterovitz G, Otu HH, Grall F, Giagounidis AA, Wells M, Cho JY, Germing U, Czibere A et al: Optimization and evaluation of surface-enhanced laser desorption/ionization time- of-flight mass spectrometry (SELDI-TOF MS) with reversed-phase protein arrays for protein profiling. Clinical chemistry and laboratory medicine : CCLM / FESCC 2005, 43(2):133-140.
  34. Alterovitz G, Aivado M, Spentzos D, Libermann TA, Ramoni M, Kohane IS: Analysis and robot pipelined automation for SELDI-TOF mass spectrometry. Conference proceedings : Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Conference 2004, 4:3068-3071.
  35. Alterovitz G: Electrical engineering and nontechnical design variables of multiple inductive loop systems for auditoriums. Journal of deaf studies and deaf education 2004, 9(2):202-209.
  36. Alterovitz G, Staelin DH, Philip JH: Temporal patient state characterization using Iterative Order and Noise (ION) estimation: applications to anesthesia patient monitoring. Journal of clinical monitoring and computing 2002, 17(6):351-359.