Characterization of White Matter Tractography in Cortical Visual Impairment using High Angular Resolution Diffusion Imaging (HARDI)

Citation:

Bauer C, Heidary G, Koo B, Bex PJ, Merabet L. Characterization of White Matter Tractography in Cortical Visual Impairment using High Angular Resolution Diffusion Imaging (HARDI). Journal of the American Association for Pediatric Ophthalmology and Strabismus. In Press.

Abstract:

Cortical visual impairment (CVI) is currently the leading cause of pediatric visual impairment in developed countries (Durnian et al., 2010; Good et al., 2001; Hoyt, 2007; Kong et al., 2012) and is characterized by visual impairment of non-ocular cause and its presumed association with damage to central cerebral structures (Hoyt, 2007). The diagnosis of CVI is confirmed by ultrasound and standard MRI; however, these neuroimaging modalities are limited in revealing underlying neurophysiological and morphological changes to visual and other cerebral structures and their relation to observed clinical and functional visual deficits associated with CVI.