Carlo Pierpaoli, M.D., Ph.D.
Dr. Pierpaoli obtained an his M.D. from the University of Milan, Italy in 1989, the European Board Certification in Neurology in 1993, and a PhD. in Neuroscience in 1997. His research has been aimed at understanding the anatomical substrates of normal brain development and neurological disorders elucidating relationships between physiological function and brain structure, architecture and organization. Dr. Pierpaoli and his colleagues performed the first diffusion tensor imaging (DTI) studies of the human brain and received the NIH Award of Merit for this research. He has continued working in the field of diffusion MRI by proposing new metrics to describe the diffusion process, including anisotropy measures and the widely used directionally encoded color maps. Recently he and his group have been focusing on the effects of "physiological noise" in clinical MRI studies, proposing a number of approaches for increasing their accuracy and reproducibility. Diffusion tensor magnetic resonance is a successful example of the journey of neuroimaging from "bench" to "bedside" showing that by developing new imaging methods it is possible to achieve fundamental scientific insights on the structural organization of the brain in health and disease. Dr Pierpaoli has led the DTI activities related to The NIH MRI Study of Normal Brain Development (www.nih-pediatricmri.org) and guided the development of a dedicated software for analysis of MRI data from pediatric subjects (www.tortoisedti.org). He is fellow of the International Society of Magnetic Resonance in Medicine.