Publications


1: Arvanitis CD, Livingstone MS, McDannold N. Combined ultrasound and MR imaging
to guide focused ultrasound therapies in the brain. Phys Med Biol. 2013 Jul
21;58(14):4749-61. doi: 10.1088/0031-9155/58/14/4749. Epub 2013 Jun 20. PubMed
PMID: 23788054.


2: Aryal M, Vykhodtseva N, Zhang YZ, Park J, McDannold N. Multiple treatments
with liposomal doxorubicin and ultrasound-induced disruption of blood-tumor and
blood-brain barriers improve outcomes in a rat glioma model. J Control Release.
2013 Jul 10;169(1-2):103-11. doi: 10.1016/j.jconrel.2013.04.007. Epub 2013 Apr
18. PubMed PMID: 23603615.


3: Schwartz BM, McDannold NJ. Ultrasound echoes as biometric navigators. Magn
Reson Med. 2013 Apr;69(4):1023-33. doi: 10.1002/mrm.24336. Epub 2012 May 30.
PubMed PMID: 22648783.


4: Kamakura T, Nomura H, Clement GT. Application of the split-step Padé approach
to nonlinear field predictions. Ultrasonics. 2013 Feb;53(2):432-8. doi:
10.1016/j.ultras.2012.08.008. Epub 2012 Oct 3. PubMed PMID: 23099121.


5: Kopechek JA, Park E, Mei CS, McDannold NJ, Porter TM. Accumulation of
phase-shift nanoemulsions to enhance MR-guided ultrasound-mediated tumor ablation
in vivo. J Healthc Eng. 2013;4(1):109-26. doi: 10.1260/2040-2295.4.1.109. PubMed
PMID: 23502252.


6: Park EJ, Zhang YZ, Vykhodtseva N, McDannold N. Ultrasound-mediated
blood-brain/blood-tumor barrier disruption improves outcomes with trastuzumab in
a breast cancer brain metastasis model. J Control Release. 2012 Nov
10;163(3):277-84. doi: 10.1016/j.jconrel.2012.09.007. Epub 2012 Sep 18. PubMed
PMID: 23000189; PubMed Central PMCID: PMC3502612.


7: Treat LH, McDannold N, Zhang Y, Vykhodtseva N, Hynynen K. Improved anti-tumor
effect of liposomal doxorubicin after targeted blood-brain barrier disruption by
MRI-guided focused ultrasound in rat glioma. Ultrasound Med Biol. 2012
Oct;38(10):1716-25. doi: 10.1016/j.ultrasmedbio.2012.04.015. Epub 2012 Jul 19.
PubMed PMID: 22818878; PubMed Central PMCID: PMC3438387.


8: Park J, Zhang Y, Vykhodtseva N, Jolesz FA, McDannold NJ. The kinetics of blood
brain barrier permeability and targeted doxorubicin delivery into brain induced
by focused ultrasound. J Control Release. 2012 Aug 20;162(1):134-42. doi:
10.1016/j.jconrel.2012.06.012. Epub 2012 Jun 15. PubMed PMID: 22709590; PubMed
Central PMCID: PMC3520430.


9: Jing Y, Wang T, Clement GT. A k-space method for moderately nonlinear wave
propagation. IEEE Trans Ultrason Ferroelectr Freq Control. 2012
Aug;59(8):1664-73. doi: 10.1109/TUFFC.2012.2372. PubMed PMID: 22899114.


10: McDannold N, Arvanitis CD, Vykhodtseva N, Livingstone MS. Temporary
disruption of the blood-brain barrier by use of ultrasound and microbubbles:
safety and efficacy evaluation in rhesus macaques. Cancer Res. 2012 Jul
15;72(14):3652-63. doi: 10.1158/0008-5472.CAN-12-0128. Epub 2012 May 2. PubMed
PMID: 22552291; PubMed Central PMCID: PMC3533365.


11: Jing Y, Meral FC, Clement GT. Time-reversal transcranial ultrasound beam
focusing using a k-space method. Phys Med Biol. 2012 Feb 21;57(4):901-17. doi:
10.1088/0031-9155/57/4/901. Epub 2012 Jan 31. PubMed PMID: 22290477; PubMed
Central PMCID: PMC3366238.


12: Mei CS, Mulkern RV, Oshio K, Chen NK, Madore B, Panych LP, Hynynen K,
McDannold NJ. Ultrafast 1D MR thermometry using phase or frequency mapping.
MAGMA. 2012 Feb;25(1):5-14. doi: 10.1007/s10334-011-0272-9. Epub 2011 Jul 29.
PubMed PMID: 21800192; PubMed Central PMCID: PMC3245381.


13: Arvanitis CD, Livingstone MS, Vykhodtseva N, McDannold N. Controlled
ultrasound-induced blood-brain barrier disruption using passive acoustic
emissions monitoring. PLoS One. 2012;7(9):e45783. doi:
10.1371/journal.pone.0045783. Epub 2012 Sep 24. PubMed PMID: 23029240; PubMed
Central PMCID: PMC3454363.


14: Park J, Zhang Y, Vykhodtseva N, Akula JD, McDannold NJ. Targeted and
reversible blood-retinal barrier disruption via focused ultrasound and
microbubbles. PLoS One. 2012;7(8):e42754. doi: 10.1371/journal.pone.0042754. Epub
2012 Aug 13. PubMed PMID: 22912733; PubMed Central PMCID: PMC3418291.


15: Yuan J, Mei CS, Panych LP, McDannold NJ, Madore B. Towards fast and accurate
temperature mapping with proton resonance frequency-based MR thermometry. Quant
Imaging Med Surg. 2012;2(1):21-32. PubMed PMID: 22773966; PubMed Central PMCID:
PMC3389756.


16: Aljallad MH, Yuan J, Pilatou MC, McDannold NJ, Panych LP. Multiresolution MRI
temperature monitoring in a reduced field of view. Magn Reson Imaging. 2011
Nov;29(9):1205-14. doi: 10.1016/j.mri.2011.07.020. Epub 2011 Sep 9. PubMed PMID:
21908128; PubMed Central PMCID: PMC3199290.


17: Clement GT, Nomura H, Kamakura T. The feasibility of pulse compression by
nonlinear effective bandwidth extension. J Acoust Soc Am. 2011 Oct;130(4):1810-9.
doi: 10.1121/1.3625236. PubMed PMID: 21973334.


18: Jing Y, Clement GT. On the use of Gegenbauer reconstructions for shock wave
propagation modeling. J Acoust Soc Am. 2011 Sep;130(3):1115-24. doi:
10.1121/1.3621485. PubMed PMID: 21895054; PubMed Central PMCID: PMC3188966.


19: McDannold N, Zhang Y, Vykhodtseva N. Blood-brain barrier disruption and
vascular damage induced by ultrasound bursts combined with microbubbles can be
influenced by choice of anesthesia protocol. Ultrasound Med Biol. 2011
Aug;37(8):1259-70. doi: 10.1016/j.ultrasmedbio.2011.04.019. Epub 2011 Jun 8.
PubMed PMID: 21645965; PubMed Central PMCID: PMC3129385.


20: Mei CS, Panych LP, Yuan J, McDannold NJ, Treat LH, Jing Y, Madore B.
Combining two-dimensional spatially selective RF excitation, parallel imaging,
and UNFOLD for accelerated MR thermometry imaging. Magn Reson Med. 2011
Jul;66(1):112-22. doi: 10.1002/mrm.22788. Epub 2011 Feb 17. PubMed PMID:
21337421; PubMed Central PMCID: PMC3120911.


21: Tang SC, Jolesz FA, Clement GT. A wireless batteryless deep-seated
implantable ultrasonic pulser-receiver powered by magnetic coupling. IEEE Trans
Ultrason Ferroelectr Freq Control. 2011 Jun;58(6):1211-21. doi:
10.1109/TUFFC.2011.1931. PubMed PMID: 21693403.


22: Yoo SS, Bystritsky A, Lee JH, Zhang Y, Fischer K, Min BK, McDannold NJ,
Pascual-Leone A, Jolesz FA. Focused ultrasound modulates region-specific brain
activity. Neuroimage. 2011 Jun 1;56(3):1267-75. doi:
10.1016/j.neuroimage.2011.02.058. Epub 2011 Feb 24. PubMed PMID: 21354315; PubMed
Central PMCID: PMC3342684.


23: Jing Y, Shen D, Clement GT. Verification of the Westervelt equation for
focused transducers. IEEE Trans Ultrason Ferroelectr Freq Control. 2011
May;58(5):1097-101. doi: 10.1109/TUFFC.2011.1910. PubMed PMID: 21622065.


24: Yuan J, Mei CS, Madore B, McDannold NJ, Panych LP. Fast fat-suppressed
reduced field-of-view temperature mapping using 2DRF excitation pulses. J Magn
Reson. 2011 May;210(1):38-43. doi: 10.1016/j.jmr.2011.02.004. Epub 2011 Mar 2.
PubMed PMID: 21371923; PubMed Central PMCID: PMC3085949.


25: Paltiel HJ, Padua HM, Gargollo PC, Cannon GM Jr, Alomari AI, Yu R, Clement
GT. Contrast-enhanced, real-time volumetric ultrasound imaging of tissue
perfusion: preliminary results in a rabbit model of testicular torsion. Phys Med
Biol. 2011 Apr 7;56(7):2183-97. doi: 10.1088/0031-9155/56/7/018. Epub 2011 Mar
14. PubMed PMID: 21403185.


26: Tempany CM, McDannold NJ, Hynynen K, Jolesz FA. Focused ultrasound surgery in
oncology: overview and principles. Radiology. 2011 Apr;259(1):39-56. doi:
10.1148/radiol.11100155. Review. PubMed PMID: 21436096; PubMed Central PMCID:
PMC3064817.


27: Jing Y, Tao M, Clement GT. Evaluation of a wave-vector-frequency-domain
method for nonlinear wave propagation. J Acoust Soc Am. 2011 Jan;129(1):32-46.
doi: 10.1121/1.3504705. PubMed PMID: 21302985; PubMed Central PMCID: PMC3055284.


28: Clement GT. Spatial backward planar projection in absorbing media possessing
an arbitrary dispersion relation. Acoust Sci Technol. 2010 Nov 1;31(6):379-386.
PubMed PMID: 21611135; PubMed Central PMCID: PMC3099221.


29: McDannold N, Park EJ, Mei CS, Zadicario E, Jolesz F. Evaluation of
three-dimensional temperature distributions produced by a low-frequency
transcranial focused ultrasound system within ex vivo human skulls. IEEE Trans
Ultrason Ferroelectr Freq Control. 2010 Sep;57(9):1967-76. doi:
10.1109/TUFFC.2010.1644. PubMed PMID: 20875986; PubMed Central PMCID: PMC3101627.


30: McDannold N, Clement GT, Black P, Jolesz F, Hynynen K. Transcranial magnetic
resonance imaging- guided focused ultrasound surgery of brain tumors: initial
findings in 3 patients. Neurosurgery. 2010 Feb;66(2):323-32; discussion 332. doi:
10.1227/01.NEU.0000360379.95800.2F. PubMed PMID: 20087132; PubMed Central PMCID:
PMC2939497.


31: Tang SC, Clement GT. Standing-wave suppression for transcranial ultrasound by
random modulation. IEEE Trans Biomed Eng. 2010 Jan;57(1):203-5. doi:
10.1109/TBME.2009.2028653. Epub 2009 Aug 18. PubMed PMID: 19695991; PubMed
Central PMCID: PMC2887681.


32: Madore B, White PJ, Thomenius K, Clement GT. Accelerated focused ultrasound
imaging. IEEE Trans Ultrason Ferroelectr Freq Control. 2009 Dec;56(12):2612-23.
doi: 10.1109/TUFFC.2009.1352. PubMed PMID: 20040398; PubMed Central PMCID:
PMC2813841.


33: Fischer K, McDannold NJ, Zhang Y, Kardos M, Szabo A, Szabo A, Reusz GS,
Jolesz FA. Renal ultrafiltration changes induced by focused US. Radiology. 2009
Dec;253(3):697-705. doi: 10.1148/radiol.2532082100. Epub 2009 Jul 31. PubMed
PMID: 19703861; PubMed Central PMCID: PMC2786196.


34: Farny CH, Clement GT. Ultrasound phase contrast thermal imaging with reflex
transmission imaging methods in tissue phantoms. Ultrasound Med Biol. 2009
Dec;35(12):1995-2006. doi: 10.1016/j.ultrasmedbio.2009.05.019. Epub 2009 Aug 14.
PubMed PMID: 19683380; PubMed Central PMCID: PMC2790025.


35: Taran FA, Tempany CM, Regan L, Inbar Y, Revel A, Stewart EA; MRgFUS Group.
Magnetic resonance-guided focused ultrasound (MRgFUS) compared with abdominal
hysterectomy for treatment of uterine leiomyomas. Ultrasound Obstet Gynecol. 2009
Nov;34(5):572-8. doi: 10.1002/uog.7435. PubMed PMID: 19852046.


36: Tang SC, Clement GT. Acoustic standing wave suppression using randomized
phase-shift-keying excitations. J Acoust Soc Am. 2009 Oct;126(4):1667-70. doi:
10.1121/1.3203935. PubMed PMID: 19813782; PubMed Central PMCID: PMC2771052.


37: Shen SH, Fennessy F, McDannold N, Jolesz F, Tempany C. Image-guided thermal
therapy of uterine fibroids. Semin Ultrasound CT MR. 2009 Apr;30(2):91-104.
Review. PubMed PMID: 19358440; PubMed Central PMCID: PMC2768544.


38: Pilatou MC, Stewart EA, Maier SE, Fennessy FM, Hynynen K, Tempany CM,
McDannold N. MRI-based thermal dosimetry and diffusion-weighted imaging of
MRI-guided focused ultrasound thermal ablation of uterine fibroids. J Magn Reson
Imaging. 2009 Feb;29(2):404-11. doi: 10.1002/jmri.21688. PubMed PMID: 19161196;
PubMed Central PMCID: PMC2754252.


39: White PJ, Whalen S, Tang SC, Clement GT, Jolesz F, Golby AJ. An
intraoperative brain shift monitor using shear mode transcranial ultrasound:
preliminary results. J Ultrasound Med. 2009 Feb;28(2):191-203. PubMed PMID:
19168769; PubMed Central PMCID: PMC2631551.


40: McDannold N, Tempany C, Jolesz F, Hynynen K. Evaluation of referenceless
thermometry in MRI-guided focused ultrasound surgery of uterine fibroids. J Magn
Reson Imaging. 2008 Oct;28(4):1026-32. doi: 10.1002/jmri.21506. PubMed PMID:
18821603; PubMed Central PMCID: PMC2574694.


41: Lénárd ZM, McDannold NJ, Fennessy FM, Stewart EA, Jolesz FA, Hynynen K,
Tempany CM. Uterine leiomyomas: MR imaging-guided focused ultrasound
surgery--imaging predictors of success. Radiology. 2008 Oct;249(1):187-94. doi:
10.1148/radiol.2491071600. Epub 2008 Aug 11. PubMed PMID: 18695211; PubMed
Central PMCID: PMC2657858.


42: McDannold N, Maier SE. Magnetic resonance acoustic radiation force imaging.
Med Phys. 2008 Aug;35(8):3748-58. PubMed PMID: 18777934; PubMed Central PMCID:
PMC2673647.


43: Vykhodtseva N, McDannold N, Hynynen K. Progress and problems in the
application of focused ultrasound for blood-brain barrier disruption.
Ultrasonics. 2008 Aug;48(4):279-96. doi: 10.1016/j.ultras.2008.04.004. Epub 2008
Apr 14. Review. PubMed PMID: 18511095; PubMed Central PMCID: PMC2569868.


44: Sheikov N, McDannold N, Sharma S, Hynynen K. Effect of focused ultrasound
applied with an ultrasound contrast agent on the tight junctional integrity of
the brain microvascular endothelium. Ultrasound Med Biol. 2008
Jul;34(7):1093-104. doi: 10.1016/j.ultrasmedbio.2007.12.015. Epub 2008 Apr 18.
PubMed PMID: 18378064; PubMed Central PMCID: PMC2518085.


45: McDannold N, Vykhodtseva N, Hynynen K. Effects of acoustic parameters and
ultrasound contrast agent dose on focused-ultrasound induced blood-brain barrier
disruption. Ultrasound Med Biol. 2008 Jun;34(6):930-7. doi:
10.1016/j.ultrasmedbio.2007.11.009. Epub 2008 Feb 21. PubMed PMID: 18294757;
PubMed Central PMCID: PMC2459318.


46: Raymond SB, Treat LH, Dewey JD, McDannold NJ, Hynynen K, Bacskai BJ.
Ultrasound enhanced delivery of molecular imaging and therapeutic agents in
Alzheimer's disease mouse models. PLoS One. 2008 May 14;3(5):e2175. doi:
10.1371/journal.pone.0002175. PubMed PMID: 18478109; PubMed Central PMCID:
PMC2364662.


47: McDannold N, Vykhodtseva N, Hynynen K. Blood-brain barrier disruption induced
by focused ultrasound and circulating preformed microbubbles appears to be
characterized by the mechanical index. Ultrasound Med Biol. 2008
May;34(5):834-40. doi: 10.1016/j.ultrasmedbio.2007.10.016. Epub 2008 Jan 22.
PubMed PMID: 18207311; PubMed Central PMCID: PMC2442477.


48: Farny CH, Clement GT. Feasibility of ultrasound phase contrast for heating
localization. J Acoust Soc Am. 2008 Mar;123(3):1773-83. doi: 10.1121/1.2835438.
PubMed PMID: 18345865.


49: Tang SC, Clement GT. A harmonic cancellation technique for an ultrasound
transducer excited by a switched-mode power converter. IEEE Trans Ultrason
Ferroelectr Freq Control. 2008 Feb;55(2):359-67. doi: 10.1109/TUFFC.2008.654.
Erratum in: IEEE Trans Ultrason Ferroelectr Freq Control. 2008 Mar;55(3):738.
PubMed PMID: 18334342.


50: Jolesz FA, McDannold N. Current status and future potential of MRI-guided
focused ultrasound surgery. J Magn Reson Imaging. 2008 Feb;27(2):391-9. doi:
10.1002/jmri.21261. Review. PubMed PMID: 18219674.


51: Pichardo S, Hynynen K. Treatment of near-skull brain tissue with a focused
device using shear-mode conversion: a numerical study. Phys Med Biol. 2007 Dec
21;52(24):7313-32. Epub 2007 Dec 5. PubMed PMID: 18065841.


52: McDannold N, Barnes AS, Rybicki FJ, Oshio K, Chen NK, Hynynen K, Mulkern RV.
Temperature mapping considerations in the breast with line scan echo planar
spectroscopic imaging. Magn Reson Med. 2007 Dec;58(6):1117-23. PubMed PMID:
18046702.


53: White PJ, Clement GT. Two-dimensional localization with a single diffuse
ultrasound field excitation. IEEE Trans Ultrason Ferroelectr Freq Control. 2007
Nov;54(11):2309-17. PubMed PMID: 18051165.


54: Tang SC, Clement GT, Hynynen K. A computer-controlled ultrasound
pulser-receiver system for transskull fluid detection using a shear wave
transmission technique. IEEE Trans Ultrason Ferroelectr Freq Control. 2007
Sep;54(9):1772-83. PubMed PMID: 17941383; PubMed Central PMCID: PMC2186207.


55: Treat LH, McDannold N, Vykhodtseva N, Zhang Y, Tam K, Hynynen K. Targeted
delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided
focused ultrasound. Int J Cancer. 2007 Aug 15;121(4):901-7. PubMed PMID:
17437269.


56: White PJ, Palchaudhuri S, Hynynen K, Clement GT. The effects of desiccation
on skull bone sound speed in porcine models. IEEE Trans Ultrason Ferroelectr Freq
Control. 2007 Aug;54(8):1708-10. PubMed PMID: 17703676.


57: Fennessy FM, Tempany CM, McDannold NJ, So MJ, Hesley G, Gostout B, Kim HS,
Holland GA, Sarti DA, Hynynen K, Jolesz FA, Stewart EA. Uterine leiomyomas: MR
imaging-guided focused ultrasound surgery--results of different treatment
protocols. Radiology. 2007 Jun;243(3):885-93. Epub 2007 Apr 19. PubMed PMID:
17446521.


58: McDannold N, Vykhodtseva N, Hynynen K. Use of ultrasound pulses combined with
Definity for targeted blood-brain barrier disruption: a feasibility study.
Ultrasound Med Biol. 2007 Apr;33(4):584-90. PubMed PMID: 17337109; PubMed Central
PMCID: PMC2066193.


59: Hynynen K, Clement G. Clinical applications of focused ultrasound-the brain.
Int J Hyperthermia. 2007 Mar;23(2):193-202. Review. PubMed PMID: 17578343.


60: Clement GT. Two-dimensional ultrasound detection with unfocused
frequency-randomized signals. J Acoust Soc Am. 2007 Jan;121(1):636-47. PubMed
PMID: 17297817; PubMed Central PMCID: PMC1839069.


61: Vykhodtseva N, McDannold N, Hynynen K. Induction of apoptosis in vivo in the
rabbit brain with focused ultrasound and Optison. Ultrasound Med Biol. 2006
Dec;32(12):1923-9. PubMed PMID: 17169704.


62: McDannold N, Hynynen K. Quality assurance and system stability of a clinical
MRI-guided focused ultrasound system: four-year experience. Med Phys. 2006
Nov;33(11):4307-13. PubMed PMID: 17153409.


63: McDannold NJ, Vykhodtseva NI, Hynynen K. Microbubble contrast agent with
focused ultrasound to create brain lesions at low power levels: MR imaging and
histologic study in rabbits. Radiology. 2006 Oct;241(1):95-106. PubMed PMID:
16990673.


64: Dimaio SP, Archip N, Hata N, Talos IF, Warfield SK, Majumdar A, Mcdannold N,
Hynynen K, Morrison PR, Wells WM 3rd, Kacher DF, Ellis RE, Golby AJ, Black PM,
Jolesz FA, Kikinis R. Image-guided neurosurgery at Brigham and Women's Hospital.
IEEE Eng Med Biol Mag. 2006 Sep-Oct;25(5):67-73. PubMed PMID: 17020201.


65: Hynynen K, McDannold N, Vykhodtseva N, Raymond S, Weissleder R, Jolesz FA,
Sheikov N. Focal disruption of the blood-brain barrier due to 260-kHz ultrasound
bursts: a method for molecular imaging and targeted drug delivery. J Neurosurg.
2006 Sep;105(3):445-54. PubMed PMID: 16961141.


66: Sheikov N, McDannold N, Jolesz F, Zhang YZ, Tam K, Hynynen K. Brain
arterioles show more active vesicular transport of blood-borne tracer molecules
than capillaries and venules after focused ultrasound-evoked opening of the
blood-brain barrier. Ultrasound Med Biol. 2006 Sep;32(9):1399-409. PubMed PMID:
16965980.


67: So MJ, Fennessy FM, Zou KH, McDannold N, Hynynen K, Jolesz FA, Stewart EA,
Rybicki FJ, Tempany CM. Does the phase of menstrual cycle affect MR-guided
focused ultrasound surgery of uterine leiomyomas? Eur J Radiol. 2006
Aug;59(2):203-7. PubMed PMID: 16766153.


68: Hynynen K, McDannold N, Clement G, Jolesz FA, Zadicario E, Killiany R, Moore
T, Rosen D. Pre-clinical testing of a phased array ultrasound system for
MRI-guided noninvasive surgery of the brain--a primate study. Eur J Radiol. 2006
Aug;59(2):149-56. Epub 2006 May 23. PubMed PMID: 16716552.


69: Kinoshita M, McDannold N, Jolesz FA, Hynynen K. Noninvasive localized
delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced
blood-brain barrier disruption. Proc Natl Acad Sci U S A. 2006 Aug
1;103(31):11719-23. Epub 2006 Jul 25. PubMed PMID: 16868082; PubMed Central
PMCID: PMC1544236.


70: Thierman JS, Clement GT, Kalish LA, O'Kane PL, Frauscher F, Paltiel HJ.
Automated sonographic evaluation of testicular perfusion. Phys Med Biol. 2006 Jul
21;51(14):3419-32. Epub 2006 Jun 26. PubMed PMID: 16825740.


71: McDannold N, Tempany CM, Fennessy FM, So MJ, Rybicki FJ, Stewart EA, Jolesz
FA, Hynynen K. Uterine leiomyomas: MR imaging-based thermometry and thermal
dosimetry during focused ultrasound thermal ablation. Radiology. 2006
Jul;240(1):263-72. PubMed PMID: 16793983; PubMed Central PMCID: PMC1850234.


72: White PJ, Clement GT, Hynynen K. Longitudinal and shear mode ultrasound
propagation in human skull bone. Ultrasound Med Biol. 2006 Jul;32(7):1085-96.
PubMed PMID: 16829322; PubMed Central PMCID: PMC1560344.


73: White PJ, Clement GT, Hynynen K. Local frequency dependence in transcranial
ultrasound transmission. Phys Med Biol. 2006 May 7;51(9):2293-305. Epub 2006 Apr
19. PubMed PMID: 16625043; PubMed Central PMCID: PMC1560343.


74: Kinoshita M, McDannold N, Jolesz FA, Hynynen K. Targeted delivery of
antibodies through the blood-brain barrier by MRI-guided focused ultrasound.
Biochem Biophys Res Commun. 2006 Feb 24;340(4):1085-90. Epub 2005 Dec 27. PubMed
PMID: 16403441.


75: McDannold N, Vykhodtseva N, Hynynen K. Targeted disruption of the blood-brain
barrier with focused ultrasound: association with cavitation activity. Phys Med
Biol. 2006 Feb 21;51(4):793-807. Epub 2006 Jan 25. PubMed PMID: 16467579.


76: Clement GT. Spectral image reconstruction for transcranial ultrasound
measurement. Phys Med Biol. 2005 Dec 7;50(23):5557-72. Epub 2005 Nov 16. PubMed
PMID: 16306652; PubMed Central PMCID: PMC1839070.


77: Clement GT, Huttunen J, Hynynen K. Superresolution ultrasound imaging using
back-projected reconstruction. J Acoust Soc Am. 2005 Dec;118(6):3953-60. PubMed
PMID: 16419839.


78: McDannold N, Vykhodtseva N, Raymond S, Jolesz FA, Hynynen K. MRI-guided
targeted blood-brain barrier disruption with focused ultrasound: histological
findings in rabbits. Ultrasound Med Biol. 2005 Nov;31(11):1527-37. PubMed PMID:
16286030.


79: White J, Clement GT, Hynynen K. Transcranial ultrasound focus reconstruction
with phase and amplitude correction. IEEE Trans Ultrason Ferroelectr Freq
Control. 2005 Sep;52(9):1518-22. PubMed PMID: 16285450.


80: McDannold N. Quantitative MRI-based temperature mapping based on the proton
resonant frequency shift: review of validation studies. Int J Hyperthermia. 2005
Sep;21(6):533-46. Review. PubMed PMID: 16147438.


81: Clement GT, White PJ, King RL, McDannold N, Hynynen K. A magnetic resonance
imaging-compatible, large-scale array for trans-skull ultrasound surgery and
therapy. J Ultrasound Med. 2005 Aug;24(8):1117-25. PubMed PMID: 16040827.


82: Jolesz FA, Hynynen K, McDannold N, Tempany C. MR imaging-controlled focused
ultrasound ablation: a noninvasive image-guided surgery. Magn Reson Imaging Clin
N Am. 2005 Aug;13(3):545-60. Review. PubMed PMID: 16084419.


83: Silcox CE, Smith RC, King R, McDannold N, Bromley P, Walsh K, Hynynen K.
MRI-guided ultrasonic heating allows spatial control of exogenous luciferase in
canine prostate. Ultrasound Med Biol. 2005 Jul;31(7):965-70. PubMed PMID:
15972202.


84: Aarnio J, Clement GT, Hynynen K. A new ultrasound method for determining the
acoustic phase shifts caused by the skull bone. Ultrasound Med Biol. 2005
Jun;31(6):771-80. PubMed PMID: 15936493.


85: Liu HL, McDannold N, Hynynen K. Focal beam distortion and treatment planning
in abdominal focused ultrasound surgery. Med Phys. 2005 May;32(5):1270-80. PubMed
PMID: 15984679.


86: Clement GT, Hynynen K. Ultrasound phase-contrast transmission imaging of
localized thermal variation and the identification of fat/tissue boundaries. Phys
Med Biol. 2005 Apr 7;50(7):1585-600. Epub 2005 Mar 22. PubMed PMID: 15798345.


87: Hynynen K, McDannold N, Sheikov NA, Jolesz FA, Vykhodtseva N. Local and
reversible blood-brain barrier disruption by noninvasive focused ultrasound at
frequencies suitable for trans-skull sonications. Neuroimage. 2005 Jan
1;24(1):12-20. PubMed PMID: 15588592.


88: Hindley J, Gedroyc WM, Regan L, Stewart E, Tempany C, Hynyen K, Mcdannold N,
Inbar Y, Itzchak Y, Rabinovici J, Kim HS, Geschwind JF, Hesley G, Gostout B,
Ehrenstein T, Hengst S, Sklair-Levy M, Shushan A, Jolesz F. MRI guidance of
focused ultrasound therapy of uterine fibroids: early results. AJR Am J
Roentgenol. 2004 Dec;183(6):1713-9. Erratum in: AJR Am J Roentgenol. 2005
Jan;184(1):348. Hynnen, Kullvro [corrected to Hynyen, Kullervo]; Macdanold,
Nathan [corrected to Mcdannold, Nathan]; Kim, Kevin [corrected to Kim, Hyun S];
Gostout, Brian [corrected to Gostout, Bobbie]. PubMed PMID: 15547216.


89: Jolesz FA, Hynynen K, McDannold N, Freundlich D, Kopelman D. Noninvasive
thermal ablation of hepatocellular carcinoma by using magnetic resonance
imaging-guided focused ultrasound. Gastroenterology. 2004 Nov;127(5 Suppl
1):S242-7. Review. PubMed PMID: 15508090.


90: Hynynen K, McDannold N. MRI guided and monitored focused ultrasound thermal
ablation methods: a review of progress. Int J Hyperthermia. 2004
Nov;20(7):725-37. Review. PubMed PMID: 15675668.


91: Clement GT. Perspectives in clinical uses of high-intensity focused
ultrasound. Ultrasonics. 2004 Aug;42(10):1087-93. PubMed PMID: 15234170.


92: Hynynen K, Clement GT, McDannold N, Vykhodtseva N, King R, White PJ, Vitek S,
Jolesz FA. 500-element ultrasound phased array system for noninvasive focal
surgery of the brain: a preliminary rabbit study with ex vivo human skulls. Magn
Reson Med. 2004 Jul;52(1):100-7. PubMed PMID: 15236372.


93: Sheikov N, McDannold N, Vykhodtseva N, Jolesz F, Hynynen K. Cellular
mechanisms of the blood-brain barrier opening induced by ultrasound in presence
of microbubbles. Ultrasound Med Biol. 2004 Jul;30(7):979-89. PubMed PMID:
15313330.


94: McDannold N, King RL, Hynynen K. MRI monitoring of heating produced by
ultrasound absorption in the skull: in vivo study in pigs. Magn Reson Med. 2004
May;51(5):1061-5. PubMed PMID: 15122691.


95: McDannold N, Vykhodtseva N, Jolesz FA, Hynynen K. MRI investigation of the
threshold for thermally induced blood-brain barrier disruption and brain tissue
damage in the rabbit brain. Magn Reson Med. 2004 May;51(5):913-23. PubMed PMID:
15122673.


96: Clement GT, White PJ, Hynynen K. Enhanced ultrasound transmission through the
human skull using shear mode conversion. J Acoust Soc Am. 2004
Mar;115(3):1356-64. PubMed PMID: 15058357.


97: McDannold N, Fossheim SL, Rasmussen H, Martin H, Vykhodtseva N, Hynynen K.
Heat-activated liposomal MR contrast agent: initial in vivo results in rabbit
liver and kidney. Radiology. 2004 Mar;230(3):743-52. Epub 2004 Feb 5. PubMed
PMID: 14764890.


98: Clement GT, Hynynen K. Forward planar projection through layered media. IEEE
Trans Ultrason Ferroelectr Freq Control. 2003 Dec;50(12):1689-98. PubMed PMID:
14761040.


99: McDannold N, Moss M, Killiany R, Rosene DL, King RL, Jolesz FA, Hynynen K.
MRI-guided focused ultrasound surgery in the brain: tests in a primate model.
Magn Reson Med. 2003 Jun;49(6):1188-91. PubMed PMID: 12768598.


100: Tempany CM, Stewart EA, McDannold N, Quade BJ, Jolesz FA, Hynynen K. MR
imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility
study. Radiology. 2003 Mar;226(3):897-905. PubMed PMID: 12616023.


101: Hynynen K, McDannold N, Martin H, Jolesz FA, Vykhodtseva N. The threshold
for brain damage in rabbits induced by bursts of ultrasound in the presence of an
ultrasound contrast agent (Optison). Ultrasound Med Biol. 2003 Mar;29(3):473-81.
PubMed PMID: 12706199.


102: King RL, Clement GT, Maruvada S, Hynynen K. Preliminary results using
ultrasound transmission for image-guided thermal therapy. Ultrasound Med Biol.
2003 Feb;29(2):293-9. PubMed PMID: 12659917.


103: Hynynen K, McDannold N, Vykhodtseva N, Jolesz FA. Non-invasive opening of
BBB by focused ultrasound. Acta Neurochir Suppl. 2003;86:555-8. PubMed PMID:
14753505.


104: Connor CW, Clement GT, Hynynen K. A unified model for the speed of sound in
cranial bone based on genetic algorithm optimization. Phys Med Biol. 2002 Nov
21;47(22):3925-44. PubMed PMID: 12476974.


105: Jolesz FA, Talos IF, Schwartz RB, Mamata H, Kacher DF, Hynynen K, McDannold
N, Saivironporn P, Zao L. Intraoperative magnetic resonance imaging and magnetic
resonance imaging-guided therapy for brain tumors. Neuroimaging Clin N Am. 2002
Nov;12(4):665-83. Review. PubMed PMID: 12687918.


106: Clement GT, Hynynen K. Correlation of ultrasound phase with physical skull
properties. Ultrasound Med Biol. 2002 May;28(5):617-24. PubMed PMID: 12079698.


107: Clement GT, Hynynen K. A non-invasive method for focusing ultrasound through
the human skull. Phys Med Biol. 2002 Apr 21;47(8):1219-36. PubMed PMID: 12030552.


108: Clement GT, Hynynen K. Micro-receiver guided transcranial beam steering.
IEEE Trans Ultrason Ferroelectr Freq Control. 2002 Apr;49(4):447-53. PubMed PMID:
11989700.


109: McDannold N, King RL, Jolesz FA, Hynynen K. The use of quantitative
temperature images to predict the optimal power for focused ultrasound surgery:
in vivo verification in rabbit muscle and brain. Med Phys. 2002 Mar;29(3):356-65.
PubMed PMID: 11929019.


110: Hynynen K, McDannold N, Vykhodtseva N, Jolesz FA. Noninvasive MR
imaging-guided focal opening of the blood-brain barrier in rabbits. Radiology.
2001 Sep;220(3):640-6. PubMed PMID: 11526261.


111: Mahoney K, Fjield T, Mcdannold N, Clement G, Hynynen K. Comparison of
modelled and observed in vivo temperature elevations induced by focused
ultrasound: implications for treatment planning. Phys Med Biol. 2001
Jul;46(7):1785-98. PubMed PMID: 11474925.


112: Hynynen K, Pomeroy O, Smith DN, Huber PE, McDannold NJ, Kettenbach J, Baum
J, Singer S, Jolesz FA. MR imaging-guided focused ultrasound surgery of
fibroadenomas in the breast: a feasibility study. Radiology. 2001
Apr;219(1):176-85. PubMed PMID: 11274554.


113: McDannold N, Hynynen K, Jolesz F. MRI monitoring of the thermal ablation of
tissue: effects of long exposure times. J Magn Reson Imaging. 2001
Mar;13(3):421-7. PubMed PMID: 11241817.


114: McDannold N, Hynynen K, Oshio K, Mulkern RV. Temperature monitoring with
line scan echo planar spectroscopic imaging. Med Phys. 2001 Mar;28(3):346-55.
PubMed PMID: 11318316.


115: Clement GT, Sun J, Hynynen K. The role of internal reflection in transskull
phase distortion. Ultrasonics. 2001 Mar;39(2):109-13. PubMed PMID: 11270628.


116: Vykhodtseva N, McDannold N, Martin H, Bronson RT, Hynynen K. Apoptosis in
ultrasound-produced threshold lesions in the rabbit brain. Ultrasound Med Biol.
2001 Jan;27(1):111-7. PubMed PMID: 11295277.


117: Clement GT, Sun J, Giesecke T, Hynynen K. A hemisphere array for
non-invasive ultrasound brain therapy and surgery. Phys Med Biol. 2000
Dec;45(12):3707-19. PubMed PMID: 11131194.


118: McDannold NJ, King RL, Jolesz FA, Hynynen KH. Usefulness of MR
imaging-derived thermometry and dosimetry in determining the threshold for tissue
damage induced by thermal surgery in rabbits. Radiology. 2000 Aug;216(2):517-23.
PubMed PMID: 10924580.


119: Clement GT, Hynynen K. Field characterization of therapeutic ultrasound
phased arrays through forward and backward planar projection. J Acoust Soc Am.
2000 Jul;108(1):441-6. PubMed PMID: 10923906.


120: Hynynen K, McDannold N, Mulkern RV, Jolesz FA. Temperature monitoring in fat
with MRI. Magn Reson Med. 2000 Jun;43(6):901-4. PubMed PMID: 10861887.


121: McDannold NJ, Jolesz FA. Magnetic resonance image-guided thermal ablations.
Top Magn Reson Imaging. 2000 Jun;11(3):191-202. Review. PubMed PMID: 11145211.


122: Clement GT, White J, Hynynen K. Investigation of a large-area phased array
for focused ultrasound surgery through the skull. Phys Med Biol. 2000
Apr;45(4):1071-83. PubMed PMID: 10795992.


123: McDannold NJ, Jolesz FA, Hynynen KH. Determination of the optimal delay
between sonications during focused ultrasound surgery in rabbits by using MR
imaging to monitor thermal buildup in vivo. Radiology. 1999 May;211(2):419-26.
PubMed PMID: 10228523.


124: Sharf Y, Clement GT, Hynynen K. Absolute measurements of ultrasonic pressure
by using high magnetic fields. IEEE Trans Ultrason Ferroelectr Freq Control.
1999;46(6):1504-11. doi: 10.1109/58.808874. PubMed PMID: 18244347.


125: Foldes K, Hynynen K, Shortkroff S, Winalski CS, Collucci V, Koskinen SK,
McDannold N, Jolesz F. Magnetic resonance imaging-guided focused ultrasound
synovectomy. Scand J Rheumatol. 1999;28(4):233-7. PubMed PMID: 10503560.


126: Mulkern RV, Panych LP, McDannold NJ, Jolesz FA, Hynynen K. Tissue
temperature monitoring with multiple gradient-echo imaging sequences. J Magn
Reson Imaging. 1998 Mar-Apr;8(2):493-502. PubMed PMID: 9562081.