The ICCB-Longwood Screening Facility assists investigators in conducting high-throughput screens of chemical and functional genomics libraries to identify new tools for biological research. The ICCB-Longwood compound collection is continuously growing. Over 500,000 compounds are currently available for screening, including > ~15,000 'known bioactive' compounds, many of which have been characterized in animal models or in the clinic. Multiple human and mouse whole-genome siRNA libraries, as well as miRNA mimic and inhibitor libraries, are available for RNAi screening. Arrayed, synthetic single-guide RNA libraries targeting the human draggable genome are available for CRISPR knock out screening. Laboratory automation equipment is also available for use by the community for non-screening projects. The facility employs a staff-assisted screening model.
Core Director - Jennifer Smith
Core Assistant Director - Patricia Szajner
Core Website - http://iccb.med.harvard.edu/