@article {5608,
	title = {Signals transmitted along retinal axons in Drosophila: Hedgehog signal reception and the cell circuitry of lamina cartridge assembly.},
	journal = {Development (Cambridge, England)},
	volume = {125},
	number = {19},
	year = {1998},
	note = {n/a
},
	month = {1998 Oct},
	pages = {3753-64},
	abstract = {The arrival of retinal axons in the brain of Drosophila triggers the assembly of glial and neuronal precursors into a {\textquoteright}neurocrystalline{\textquoteright} array of lamina synaptic {\textquoteright}cartridges{\textquoteright}. Hedgehog, a secreted protein, is an inductive signal delivered by retinal axons for the initial steps of lamina differentiation. In the development of many tissues, Hedgehog acts in a signal relay cascade via the induction of secondary secreted factors. Here we show that lamina neuronal precursors respond directly to Hedgehog signal reception by entering S-phase, a step that is controlled by the Hedgehog-dependent transcriptional regulator Cubitus interruptus. The terminal differentiation of neuronal precursors and the migration and differentiation of glia appear to be controlled by other retinal axon-mediated signals. Thus retinal axons impose a program of developmental events on their postsynaptic field utilizing distinct signals for different precursor populations.
},
	author = {Huang, Z and Kunes, S}
}
