This is a cross-institutional initiative that brings together faculty from across Harvard to study and implement ways to better integrate religion and spirituality into the practice of medicine and public health. The initiative began through a synergistic, research-focused relationship of a trio of medical, epidemiological, & theological faculty at Harvard University. The Center is housed through a joint partnership between multiple Harvard-affiliated institutions. This partnership has led to a wider vision tasked to foster an interdisciplinary collaboration and bridge-building endeavor beginning with other faculty and students. The initiative values interfaculty teams of researchers who apply stringent scientific methods of analysis and scholarly lines of inquiry seeking to discover individual and social connections of spirit, mind, and body within the healthcare context. Advancement of spirituality research is energized by the practical concern that new discoveries from spiritual and religious resources will yield significant new gains in alleviating illness and promoting human flourishing.