• Image: Cell-cycle regulation and cancer

    Cell-cycle regulation and cancer

  • Image: Single-molecule enzymology: pushing the limit of detection

    Single-molecule enzymology: pushing the limit of detection

  • Image: Biological specificity

    Biological specificity

  • The regulation of protein turnover

    The regulation of protein turnover

Accuracy is a remarkable feature of a large number of biological processes. To maintain homeostasis, cellular protein degradation must be carried out with no less precision or efficiency than transcription and translation. My lab is trying to understand how the cell achieves accurate control of protein degradation and how its failure may lead to neurodegeneration and aging. We evolve modern enzymological methodology, namely single-molecule fluorescence/force spectroscopy, cryo-electron microscopy and molecular dynamics simulation, to investigate how the information in ubiquitin configurations is decoded by the proteasome, a universal molecular machine in eukaryotic species, to command accurate degradation of cellular proteins.