ASK2ME provides a calculator to determine risk and the existing management guidelines for most of these genes (with more to follow). We have chosen the best papers we can find on ATM, BARD1, BRCA1, BRCA2, BRIP1, BMPR1A, CDH1, CDK4, CDKN2A, CHEK2, EPCAM, GREM1, MLH1, MSH2, MSH6, MUTYH, NBN, PALB2, PMS2, POLD1, POLE, PTEN, RAD50, RAD51C, RAD51D, SMAD4, STK11, TP53, and converted their general risk estimates to patient specific estimates, and collated the major management guidelines to simplify determining a management strategy.