Our methodological research consideres statisical and machine learning challenges that we think are critical for better developing and evaluating prediction models. Examples of ongoing projects include:
- Accounting for misreporting of family history in Mendelian risk prediction models.
- Using a frailty model to account for unobserved genetic and environmental effects in Mendelian risk prediction models.
- Accounting for missing data in Mendelian risk prediction models.
- Combining predictions from multiple risk models.
- Developing statistical methods to conduct meta-analysis of penetrance estimates.
- Developing statistical methods to conduct meta-analysis of prevalence estimaets.
- Developing Mendelian risk models that consider multiple genetic syndromes together.
- Developing computational approaches to extend Mendelian models to large number of genes and cancers.
- Updating and extending existing Mendelian models including; BRCApro, MMRPRO, PancPro, MelaPro, and LFSpro.
- Developing machine learning tools that can learn mendelian inheritance patterns.