Our Software

Software Use

Our software is free to use for research and nonprofit work. Commercial software development that incorporates our software requires a license. Please contact Giovanni Parmigiani for information on licensing. 



BayesMendel is an R package for Mendelian risk prediction. It includes implementation of the BRCAPRO, MMRpro, PancPRO and MelaPRO models, as well as functionality to adapt BRCAPRO, MMRpro, PancPRO and MelaPRO to specific populations and to develop new Mendelian risk prediction models for other syndromes.


ASK2ME is a clinician facing decision support tool for individuals who have undergone multi-gene panel testing, developed in collaboration with Dr. Kevin Hughes at MGH. 

ASK2ME provides a calculator to determine risk and the existing management guidelines for most of these genes (with more to follow). We have chosen the best papers we can find on ATM, BARD1, BRCA1, BRCA2, BRIP1, BMPR1A, CDH1, CDK4, CDKN2A, CHEK2, EPCAM, GREM1, MLH1, MSH2, MSH6, MUTYH, NBN, PALB2, PMS2, POLD1, POLE, PTEN, RAD50, RAD51C, RAD51D, SMAD4, STK11, TP53, and converted their general risk estimates to patient specific estimates, and collated the major management guidelines to simplify determining a management strategy.