# PanelPRO Updates Log

Vesrsion 0.2.0 08/01/2021

Major changes

• The PanelPRO-24 model specification has been updated to include 18 instead of 11 cancers: Brain, Breast, Cervical, Colorectal, Endometrial, Gastric, Hepatobiliary, Kidney, Leukemia, Melanoma, Ovarian, Osteosarcoma, Pancreas, Prostate, Small Intestine, Soft Tissue Sarcoma, Thyroid, and Urinary Bladder.

• Eight additional test pedigrees have been added: test_fam_5 through test_fam_12.

• PanelPRODatabase has been updated to remove the association between male breast cancer and BRCA1.

• When an individual in the pedigree has an age of cancer diagnosis that is greater than their current age, checkFam now raises an error and suggests that if the user cannot resolve the age inputs, the maximum cancer age can be entered as the current age.

Minor changes

• When one or more of the carrier probabilities is 0, germline testing results were incorporated, and the default sensitivities/specifities of 1 were used, a warning will be issued that suggests a more accurate estimate may be achieved with user-specified sensitivities and specificities.

• The new ignore.proband.germ argument in PanelPRO allows users the option to ignore proband germline testing results (if provided) from being considered by the model.

• When the current age of one or more living probands is equal to PanelPRO:::MAXAGE, no future risk probabilities will be calculated for these individuals.

Bug fixes

• A bug that scrambled the model parameters for the breast tumor markers has been fixed.

• Imputed ages can no longer exceed the legal range of ages (between 1 and PanelPRO:::MAXAGE).

Version 0.1.0 03/22/2021 Initital package release