Min Dong (董民), Ph.D.
Department of Microbiology and Immunobiology, Harvard Medical School
Research Interests: bacterial toxins, botulinum neurotoxin, microbiome, synaptic vesicles, membrane trafficking, clostridium difficile, protein engineering, protein therapeutics
Our laboratory has a broad interest in microbial toxins and host-microbe interactions. We are also interested in membrane trafficking and cytoskeleton remodeling in neurons. Along these lines of basic research, we are keen in developing microbial toxin-inspired scientific tools and novel therapeutics. We have a multi-disciplinary team crossing microbiology, protein engineering, cell biology, and neuroscience fields. The current research areas include (1) Mechanism of bacterial toxins and effectors, including botulinum neurotoxins, tetanus neurotoxin, Shiga toxin, Clostridium difficile toxins, and many bacterial effectors; (2) Host-microbe interactions: enteric pathogens (e.g., C. difficile infections) and microbiome; urinary tract infections and urinary microbiome; (3) Developing novel therapeutic toxins: apply modern protein engineering methods to develop novel therapeutic toxins for treating chronic pain and cancer; (4) Synaptic vesicle exocytosis/recycling and cytoskeleton regulation by ROCO kinases.
Dr. Min Dong received his B.S. degree from University of Science and Technology of China (USTC) in 1997 and Ph.D. degree in neuroscience from the University of Wisconsin – Madison in 2004. He continued his postdoctoral training in the laboratory of Dr. Edwin Chapman at the University of Wisconsin – Madison. Dr. Dong established his independent lab in 2009 at the New England Primate Research Center of Harvard Medical School. He later joined Dept. of Urology at Boston Children’s Hospital in 2015.