Xiao Zhen Zhou (周小珍), MD, PhD

Xiao Zhen Zhou (周小珍), MD, PhD

Assistant Professor, Division of Translational Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School
Research Interests : Pin1; cis-trans proline isomerase; phosphorylation signaling; protein conformation regulation; PinX1; telomerase inhibitor; cancer; Alzheimer’s disease; brain injury
Zhouxiaozhen
Xiao Zhen Zhou is an Assistant Professor at Beth Israel Deaconess Medical Center and Harvard Medical School. After receiving her MD from Suzhou Medical College, she started her research career at Duke University and then Scripps Research Institute, working on phosphorylation signaling in mammals and bacteria, respectively. After joining Kun Ping Lu, she has established the fundamental principle of Pin1-catalyzed regulatory mechanism and also identified several Pin2/TRF1-interacting proteins, including PinX1, the first mammalian endogenous telomerase inhibitor and a tumor suppressor. After becoming a faculty at Harvard, in addition to working on PinX1 in telomere regulation and cancer development, she has been responsible for developing new technologies, including Pin1 drug screens and conformation-specific antibodies, to elucidate the roles of Pin1-catalyzed conformational changes in health and disease. In collaboration with Kun Ping Lu, she currently focuses on the elucidation of cis-trans conformational changes in disease development, and the development of Pin1-targeted new diagnostics and therapies, including Pin1 inhibitors to block multiple cancer-driving pathways and eliminate cancer stem cells, and cis P-tau antibody to neutralize a major early driver of neurodegeneration in Alzheimer’s disease and brain injury.

Contact Information

Center for Life Science, Room 0413, 3 Blackfan Circle, Boston, MA  02115
p: 617-735-2017