Xiaobo Zhou (周晓波), Ph.D.
Research Interests: GWAS, COPD, Genome editing, asthma, functional genomics
The central goal of my research group is to decode the molecular mechanism by which genetic variants identified by genome-wide association studies (GWAS) determine disease susceptibility to asthma and COPD by using in vitro and in vivo “loss-of-function” as well as integrative approaches. Funded by several NIH R01 or P01 grants, we have developed integrative approaches to identify regulatory DNA regions, localize functional variants, and evaluate the function of novel COPD GWAS genes in vitro and in vivo in conventional and conditional knockout mice. We are currently developing the CRSIRP/Cas-9 based screening in iPSC-derived cellular models and disease relevant murine models to rapidly perform functional assessments on increasing number of COPD GWAS genes.
Dr Zhou’s group published the first paper on functional variants identification in COPD nearby HHIP region. Her group has published multiple papers related with functional variants identification and subsequent functional dissections on GWAS candidate genes in COPD and asthma using cellular and murine models. In last few years, her group has published papers in NEJM, JACI, AJRCCM, Lancet Respiratory, Human Molecular Genetics and PNAS et al journals. Before she established Functional Genomics Laboratory in BWH, she obtained her Ph.D in cancer cell biology from Chinese Academy of Medical Science in Beijing and finished post-doctoral training at Harvard Medical School.
221 Longwood Ave
Boston MA 02115