Yi Zhang (张毅), Ph.D.
Professor of Genetics and Pediatrics, Harvard Medical School & Boston Children’s Hospital
Research Interests : Epigenetics, Chromatin, Transcription, Stem Cell, Reprogramming, SCNT, Brain Reward, Addiction, Cancer, Single Cell Technology
Yi Zhang obtained his Ph.D and postdoctoral fellow training at Florida State University and the Robert Wood Johnson Medical School, respectively. Before he moved to Harvard Medical School and Boston Children’s Hospital to take the Fred Rosen Chair position in 2012, he was the Kenan Distinguished Professor at the University of North Carolina at Chapel Hill. His major scientific contributions include the identification and characterization of various epigenetic enzymes such as the Polycomb repressive complex PRC1 and PRC2, the JmjC family of histone demethylases, and the Tet family of 5mC dioxygenases. He also identified a key epigenetic barrier in SCNT reprogramming and found a simple solution to drastically increase the efficiency of animal cloning. His current focuses include the mechanism of preimplantation development and SCNT reprogramming, mechanism of brain reward and addiction, cancer development and treatment-induced drug resistance. His honors include the appointment to the Howard Hughes Medical Institute (2005), the top 10 authors of high-impact papers in molecular biology and genetics by ScienceWatch (2008), the Senior Investigator Award from the Chinese Biological Investigator Society (2009), and Elected Fellow of the American Association for the Advancement of Science (2013).