10.16.2013 Chapter in new book

October 16, 2013

Contribution to new book: Pathobiology of Cancer Regimen-Related Toxicities

Chapter Abstract: “The efficacy of chemotherapy depends on several different patient ­factors, including age, gender, ethnicity, and genetics. A patient’s genetic composition strongly influences how chemotherapeutic agents are absorbed, distributed, metabolized, and excreted by the body. Consequently, variations in genes that are responsible for these activities play a significant role in determining the prognostic outcome for patients. Studying and identifying these associated genes have been main foci of chemotherapy research, and much progress has been made in understanding the metabolic relationship between genes and chemotherapeutic agents. This understanding can be used to personalize chemotherapy regimens and ensure that treatment benefits outweigh treatment risks.”

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