Dr. Homan Kang
Faculty, Bioengineering & Nanomedicine Program, GCMI
Assistant Chemist, Massachusetts General Hospital
Dr. Homan Kang is a faculty member of Bioimaging & Nanomedicine Program at the Gordon Center for Medical Imaging of MGH and Harvard Medical School. Dr. Kang is a graduate of the Polymer Science and Engineering/Nanoscience and Technology (double major) at Dankook University, South Korea and earned a Ph.D. degree in Nano-Science and Technology from Seoul National University in 2014. His research interests at Harvard Medical School center around an understanding in vivo transport and nano-bio interactions of theranostic nanoparticles (NPs) in the body for diagnosis, staging, and treatment of human diseases. He has a broad and unique background in the field of nanomedicine and drug delivery, and recently developed original ideas for biomedical applications. As a postdoctoral fellow at Harvard Medical School, working with our collaborator Dr. Jean-Luc Coll (Program Director of Cancer Targets and Experimental Therapeutics) at the University of Grenoble-Alpes in France, they have created renal clearable organic nanocarriers for targeting and drug delivery to gastrointestinal stromal tumors (GIST). He has precisely defined the hydrodynamic diameter, surface charges, mass-to-charge ratio, and elimination kinetics that permit nanoparticles for renal clearance. These results have been published in a top-ranked materials chemistry journal (Advanced Materials, 2016 and 2020), which will likely have a major impact on the design of biocompatible delivery vehicles for anticancer drugs. After he took a faculty position at MGH, in collaboration with Dr. Jonghan Kim at University of Massachusetts Lowell, they have been studying the relationship among the size, charge, lipophilicity, and pharmacokinetics of nanoparticles for iron chelation therapy. Based on the results, they have developed ultrasmall iron nanochelators that could capture iron from the body, without distributing to off-target tissue, and leave the body through urinary excretion (Nature Communications, 2019). These nanochelators distribute rapidly into deep target tissues, bind strongly to free iron in the blood and tissues, and quickly clear to the urinary bladder without redistribution.
Charlestown, MA 02129