Image-guided surgery using invisible near-infrared light: fundamentals of clinical translation


S. Gioux, H. S. Choi, and J. V. Frangioni. 2010. “Image-guided surgery using invisible near-infrared light: fundamentals of clinical translation.” Molecular imaging, 9, Pp. 237-55.


The field of biomedical optics has matured rapidly over the last decade and is poised to make a significant impact on patient care. In particular, wide-field (typically > 5 cm), planar, near-infrared (NIR) fluorescence imaging has the potential to revolutionize human surgery by providing real-time image guidance to surgeons for tissue that needs to be resected, such as tumors, and tissue that needs to be avoided, such as blood vessels and nerves. However, to become a clinical reality, optimized imaging systems and NIR fluorescent contrast agents will be needed. In this review, we introduce the principles of NIR fluorescence imaging, analyze existing NIR fluorescence imaging systems, and discuss the key parameters that guide contrast agent development. We also introduce the complexities surrounding clinical translation using our experience with the Fluorescence-Assisted Resection and Exploration (FLARE) imaging system as an example. Finally, we introduce state-of-the-art optical imaging techniques that might someday improve image-guided surgery even further.


Gioux, SylvainChoi, Hak SooFrangioni, John VR01 CA115296-07/CA/NCI NIH HHS/R01 EB005805-04/EB/NIBIB NIH HHS/R01-CA-115296/CA/NCI NIH HHS/R01-EB-0005805/EB/NIBIB NIH HHS/R21 CA130297-02/CA/NCI NIH HHS/R21-CA-130297/CA/NCI NIH HHS/Mol Imaging. 2010 Oct;9(5):237-55.