Renal clearable organic nanocarriers for bioimaging and drug delivery

Citation:

H. Kang, J. Gravier, K. Bao, H. Wada, J. H. Lee, Y. Baek, G. El Fakhri, S. Gioux, B. P. Rubin, J. L. Coll, and H. S. Choi. 2016. “Renal clearable organic nanocarriers for bioimaging and drug delivery.” Adv Mater, 28, Pp. 8162-8168.

Abstract:

Renally cleared zwitterionic nanocarriers (H-Dots) are composed of epsilon-polylysine backbone for charge variations, near-infrared fluorophores for bioimaging, and beta-cyclodextrins for potential drug delivery. H-Dots show ideal systemic circulation and rapid distribution and excrete from normal tissue/organ via renal excretion after complete targeting to the tumor site without nonspecific uptake by the immune system.

Notes:

Kang, HomanGravier, JulienBao, KaiWada, HideyukiLee, Jeong HeonBaek, YoonjiEl Fakhri, GeorgesGioux, SylvainRubin, Brian PColl, Jean-LucChoi, Hak SooengR01 EB011523/EB/NIBIB NIH HHS/GermanyAdv Mater. 2016 Oct;28(37):8162-8168. doi: 10.1002/adma.201601101. Epub 2016 Jul 14.