Renal clearable organic nanocarriers for bioimaging and drug delivery


H. Kang, J. Gravier, K. Bao, H. Wada, J. H. Lee, Y. Baek, G. El Fakhri, S. Gioux, B. P. Rubin, J. L. Coll, and H. S. Choi. 2016. “Renal clearable organic nanocarriers for bioimaging and drug delivery.” Adv Mater, 28, Pp. 8162-8168.


Renally cleared zwitterionic nanocarriers (H-Dots) are composed of epsilon-polylysine backbone for charge variations, near-infrared fluorophores for bioimaging, and beta-cyclodextrins for potential drug delivery. H-Dots show ideal systemic circulation and rapid distribution and excrete from normal tissue/organ via renal excretion after complete targeting to the tumor site without nonspecific uptake by the immune system.


Kang, HomanGravier, JulienBao, KaiWada, HideyukiLee, Jeong HeonBaek, YoonjiEl Fakhri, GeorgesGioux, SylvainRubin, Brian PColl, Jean-LucChoi, Hak SooengR01 EB011523/EB/NIBIB NIH HHS/GermanyAdv Mater. 2016 Oct;28(37):8162-8168. doi: 10.1002/adma.201601101. Epub 2016 Jul 14.