Renal clearable theranostic nanoplatforms for gastrointestinal stromal tumors

Citation:

H. Kang, W. R. Stiles, Y. Baek, S. Nomura, K. Bao, S. Hu, G. K. Park, M. J. Jo, H. I, J. L. Coll, B. P. Rubin, and H. S. Choi. 2020. “Renal clearable theranostic nanoplatforms for gastrointestinal stromal tumors.” Adv Mater, 32, Pp. e1905899.

Abstract:

Advances in molecular imaging modalities have accelerated the diagnosis and treatment of human diseases. However, tumors less than 1 cm in size still remain difficult to localize by conventional means because of the difficulty in specific targeting/delivery to the tumor site. Furthermore, high nonspecific uptake in the major organs and persistent background retention results in low tumor-to-background ratio. The targeting and therapy of gastrointestinal stromal tumors (GIST) using nonsticky and renal clearable theranostic nanoparticles (a.k.a. H-Dots) are demonstrated. H-Dots not only target GIST for image-guided surgery, but also tailor the fate of anticancer drugs such as imatinib (IM) to the tumor site resulting in efficient treatment of unresectable GIST. In addition, H-Dots can monitor targetability, pharmacokinetics, and drug delivery, while also showing therapeutic efficacy in GIST-bearing xenograft mice following surgical resection. More importantly, IM loaded H-Dots exhibit lower uptake into the immune system, improved tumor selectivity, and increased tumor suppression compared to free IM, which accumulates in the spleen/liver. Precisely designed H-Dots can be used as a promising theranostic nanoplatform that can potentially reduce the side effects of conventional chemotherapies.

Notes:

Kang, HomanStiles, Wesley RBaek, YoonjiNomura, ShinsukeBao, KaiHu, ShuangPark, G KateJo, Min JooI, HoseokColl, Jean-LucRubin, Brian PChoi, Hak SooengR01 HL143020/HL/NHLBI NIH HHS/R01HL143020/HL/NHLBI NIH HHS/2019M3D1A1078938/National Research Foundation of KoreaNIHR21 CA223270/CA/NCI NIH HHS/#R01EB022230/EB/NIBIB NIH HHS/R01EB022230/EB/NIBIB NIH HHS/R21CA223270/CA/NCI NIH HHS/#R21CA223270/BC/NCI NIH HHS/S10 OD025234/OD/NIH HHS/2019M3D1A1078938/Ministry of Education, Science and TechnologyR01 EB022230/EB/NIBIB NIH HHS/#R01HL143020/HB/NHLBI NIH HHS/GermanyAdv Mater. 2020 Feb;32(6):e1905899. doi: 10.1002/adma.201905899. Epub 2019 Dec 18.