Renal clearable theranostic nanoplatforms for gastrointestinal stromal tumors


H. Kang, W. R. Stiles, Y. Baek, S. Nomura, K. Bao, S. Hu, G. K. Park, M. J. Jo, H. I, J. L. Coll, B. P. Rubin, and H. S. Choi. 2020. “Renal clearable theranostic nanoplatforms for gastrointestinal stromal tumors.” Adv Mater, 32, Pp. e1905899.


Advances in molecular imaging modalities have accelerated the diagnosis and treatment of human diseases. However, tumors less than 1 cm in size still remain difficult to localize by conventional means because of the difficulty in specific targeting/delivery to the tumor site. Furthermore, high nonspecific uptake in the major organs and persistent background retention results in low tumor-to-background ratio. The targeting and therapy of gastrointestinal stromal tumors (GIST) using nonsticky and renal clearable theranostic nanoparticles (a.k.a. H-Dots) are demonstrated. H-Dots not only target GIST for image-guided surgery, but also tailor the fate of anticancer drugs such as imatinib (IM) to the tumor site resulting in efficient treatment of unresectable GIST. In addition, H-Dots can monitor targetability, pharmacokinetics, and drug delivery, while also showing therapeutic efficacy in GIST-bearing xenograft mice following surgical resection. More importantly, IM loaded H-Dots exhibit lower uptake into the immune system, improved tumor selectivity, and increased tumor suppression compared to free IM, which accumulates in the spleen/liver. Precisely designed H-Dots can be used as a promising theranostic nanoplatform that can potentially reduce the side effects of conventional chemotherapies.


Kang, HomanStiles, Wesley RBaek, YoonjiNomura, ShinsukeBao, KaiHu, ShuangPark, G KateJo, Min JooI, HoseokColl, Jean-LucRubin, Brian PChoi, Hak SooengR01 HL143020/HL/NHLBI NIH HHS/R01HL143020/HL/NHLBI NIH HHS/2019M3D1A1078938/National Research Foundation of KoreaNIHR21 CA223270/CA/NCI NIH HHS/#R01EB022230/EB/NIBIB NIH HHS/R01EB022230/EB/NIBIB NIH HHS/R21CA223270/CA/NCI NIH HHS/#R21CA223270/BC/NCI NIH HHS/S10 OD025234/OD/NIH HHS/2019M3D1A1078938/Ministry of Education, Science and TechnologyR01 EB022230/EB/NIBIB NIH HHS/#R01HL143020/HB/NHLBI NIH HHS/GermanyAdv Mater. 2020 Feb;32(6):e1905899. doi: 10.1002/adma.201905899. Epub 2019 Dec 18.