Publications

2015

Kataoka K, Matsumoto H, Kaneko H, Notomi S, Takeuchi K, Sweigard JH, Atik A, Murakami Y, Connor KM, Terasaki H, Miller JW, Vavvas DG. Macrophage- and RIP3-dependent inflammasome activation exacerbates retinal detachment-induced photoreceptor cell death. Cell Death Dis. 2015 Apr 23;6:e1731.

Sampson J.F., Hasegawa E, Mulki L, Suryawanshi A, Jiang S, Chen WS, Rabinovich GA, Connor KM*,  and Panjwani, N.* Galectin-8 ameliorates murine autoimmune ocular pathology and promotes a regulatory T cell response, PLoS One. 2015; In Press.

2014

Adini I., Ghosh K, Adini A, Zailong C, Yoshimura T, Benny O, Connor KM, Rogers R, Bazinet L, Birsner A, Bielenberg DR, D’Amato RJ. Melanocytes Regulate the Angiogenic Microenvironment via Fibromodulin. Journal of Clinical Investigation. 2014; 124(1):425-36. PMID: 24355922

Takeuchi, K, Yanai, R, Kumase, F, Morizane, Y, Suzuki, J, Kayama, M, Brodowska, K, Nakazawa, M, Miller, JW, Connor, KM, Vavvas, DG. EGF-like-domain-7 is required for VEGF-induced Akt/ERK activation and vascular tube formation in an ex vivo angiogenesis assay. Plos One. 2014; 9(3):e91849. PMID: 24647208

J. Harry Sweigard, Ryoji Yanai, Aristomenis Thanos, Keiko Kataoka, Philipp Gaissert, Magali Saint-Geniez, Gregory Stahl, John D. Lambris, Connor, KM.  The Alternative Complement Pathway Regulates Pathological Angiogenesis in the Retina.  The FASEB Journal. 2014; Jul;28(7):3171-82. PMID: 24668752

Matsumoto, H, Kataoka, K, Tsoka, PA, Connor, KM, Miller, JW, Vavvas, DG. Strain Difference in Photoreceptor Cell Death After Retinal Detachment in Mice. Invest Ophthalmol Vis Sci. 2014; May 22;55(7):4165-74. PMID: 24854853

Ryoji Yanai , Lama Mulki , Eiichi Hasegawa , Kimio Takeuchi , Harry Sweigard , Jun Suzuki , Philipp Gaissert , Demetrios G Vavvas , Kohei Sonoda , Michael Rothe , Wolf-Hagen Schunck , Joan W. Miller, Connor, KM.  Cytochrome P450-generated metabolites derived from ω-3 fatty acids attenuate neovascularization. Proceedings of the National Academy of Sciences. 2014; Jul 1;111(26):9603-8. PMID: 24979774

Eiichi Hasegawa, J. Harry Sweigard, Deeba Husain, Bo Chang, Demetrios G. Vavvas, Robert D’Amato, Joan W. Miller, Connor, KM. Characterization of a spontaneous neovascular mouse model. PLoS One. 2014; Sep 4;9(9):e106507. PMID: 25188381

Lama Mulki*, J. Harry Sweigard*, and Connor, KM.  Assessing Leukocyte-Endothelial Interactions Under Flow Conditions in an Ex-vivo Autoperfused Micro-Flow Chamber Assay. Journal of Visualized Experiments. 2014; Dec 30; (94).  PMID: 25590688

2013

Saint-Geniez M, Jiang A, Abend S, Liu L, Sweigard H, Connor KM, Arany Z. PGC-1α Regulates Normal and Pathological Angiogenesis in the Retina. Am J Pathol. 2013 Jan;182(1):255-65. PMID: 23141926

Murakami Y, Matsumoto H, Roh M, Kataoka K, Morzane M, Thanos A, Nakatake S, Notomi S, Hisatomi T, Ikeda Y, Ishibashi T, Connor K.M., Miller JW, Vavvas DG. Programmed mecrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration. Cell Death and Differentiation. 2013; 21(2):270-7. PMID: 23954861

2011

Sapieha P, Stahl A, Chen J, Seaward MR, Willett KL, Krah NM, Dennison RJ, Connor KM, Aderman CM, Liclican E, Carughi A, Perelman D, Kanaoka Y, Sangiovanni JP, Gronert K, Smith LE. 5-Lipoxygenase Metabolite 4-HDHA Is a Mediator of the Antiangiogenic Effect of {omega}-3 Polyunsaturated Fatty Acids. Science Translational Medicine. 2011; 3(69):69ra12. PMID: 21307302

2010

Stahl, A.*, Sapieha, M*., Connor, K.M.*, SanGiovanni, JP., Chen, J., Aderman, C., Willett, K., Krah, N., Dennison, R., Seaward, M., Guerin, K., Hua, J., Smith, L.E. PPARγ mediates the anti-angiogenic effects of ω3-PUFAs in proliferative retinopathy. Circulation Research. 2010; 107(4):495-500. PMID: 20634487 *(Equal Contribution)

2009

Chen, J, Connor, K.M., Aderman, C.M., Willett, K.L., Aspegren, O.P., Smith, L.E.H. Suppression of retinal neovascularization by erythropoietin siRNA in a mouse model of proliferative retinopathy. Invest Ophthalmol Vis Sci. 2009:50(3): 1329-35. PMID: 18952918; PMCID: PMC2892257

Adini, A., Fainaru, O., Udagawa, T., Connor, K.M., Folkman, J., D’Amato, R.J. Matrigel Cytometry: A novel method for quantifying angiogenesis in vivo. J. Immuno. Methods. 2009 15;342(1-2):78-81. PMID: 19109967

Lofqvist. C., Willett, K.L., Aspegren, O., Smith, A.C., Aderman. C.M., Connor, K.M., Chen, J., Hellstrom, A., Smith, L.E.H. Quantification and localization of the IGF/insulin system expression in retinal blood vessels and neurons during oxygen-induced retinopathy in mice. Invest Ophthalmol Vis Sci. 2009; 50(4):1831-7. PMID: 18997086

Mammoto, A., Connor, K.M., Mammoto, T., Yung, C.W., Huh, D., Aderman, C.M., Mostoslavsky, G., Smith, L.E.H., Ingber, D.E. A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature. 2009; 457(7233):1103-8. PMID: 19242469; PMCID: PMC2708674

Stahl, A.*, Connor, K.M.*, Krah, N., Dennison, R., Willett, K., Aderman, C.A., Chen, J., Sapieha, M., Guerin, K., Smith, L.E.H. Computer-aided Quantification of Retinal Neovascularization. Angiogenesis. 2009; 12(3):297-301. (Cover Article) PMID: 19757106  *(Equal Contribution)

Connor, K.M., Krah, N., Dennison, R., Willett, K., Aderman, C.A., Chen, J., Sapieha, M., Guerin, K., Stahl, A., Smith, L.E.H. Quantification of Oxygen Induced Retinopathy in the mouse – A Model of Vessel Loss, Vessel Regrowth, and Pathological Angiogenesis. Nature Protocols. 2009; 4(11):1565-73. (Cover Article) PMID: 19816419

2008

Chen, J, Connor, K.M., Aderman, C.M., Smith, L.E.H. Erythropoietin Deficiency Decreases Vascular Stability in Mice. Journal of Clinical Investigation. 2008; 118(2):526-33. (Cover Article) PMID: 18219389; PMCID: PMC2213374

2007

Lofqvist, C, Chen, C, Connor, K.M., Smith, A.C.H, Aderman, C.M, Liu, N, Pintar, J.E, Ludwig, T, Hellstrom, A, Smith, L.E.H. IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth. PNAS. 2007; 104(25):10589-94. (Cover Article) PMID: 17567756; PMCID: PMC1965557

Connor, K.M., SanGiovanni, JP., Lofqvist, C., Aderman, C.M., Chen, J., Higuchi, A., Hong, S., Pravda, E.A., Majchrzak, S., Carper, D., Hellstrom, A., Kang, J.X., Chew, E.Y., Salem, N, Jr., Serhan, C.N., Smith, L.E.H. Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nature Medicine. 2007; 13(7):868-73. (Cover Article) PMID: 17589522

Connor, K.M., Hempel, N., Nelson, K.K., Dabiri, G., Gamarra, A., Belarmino, J., Van De Water, L., Mian, B.M., Melendez, J.A. Manganese Superoxide Dismutase enhances the invasive and migratory activity of tumor cells. Cancer Research. 2007; 67(21):10260-7. PMID: 17974967

2006

Dasgupta, J, Subbaram, S, Connor, K.M., Rodriguez, A.M, Tirosh, O, Beckman, J.S, Jourd’Heuil, D, Melendez, J.A. Manganese superoxide dismutase protects from TNF-alpha-induced apoptosis by increasing the steady-state production of H2O2. Antioxid Redox Signal. 2006; 8(7-8):1295-305. PMID: 16910777

2005

Connor, K.M., Subbaram, S., Regan, K.J., Nelson, K.K., Mazurkiewicz, J.E., Bartholomew, P.J., Aplin, A.E., Tai, Y., Aguirre-Ghiso, J., Flores, S.C., Melendez, J.A. Sod2-derived H2O2 Regulates the Angiogenic Phenotype via PTEN Oxidation. Journal of Biological Chemistry. 2005; 280(17):16916-24. PMID: 15701646

Nelson, K.K, Subbaram, S, Connor, K.M., Dasgupta J, Ha XF, Meng, T, Tonks, N.K, Melendez, J.A. Redox-dependent matrix metalloproteinase-1 expression is regulated by JNK through Ets and AP-1 promoter motifs. Journal of Biological Chemistry. 2005; 281(20):14100-10. PMID: 16569638