The Epigenetics Journal Club at the Simches Research Building is organized by members of the Lee lab, part of the Department of Molecular Biology at Massachusetts General Hospital and the Harvard Medical School Department of Genetics.Come join us on the second Tuesday of the month!Free snacks and beverages thanks to our generous sponsor Active Motif. |
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Upcoming Presentations:
08 Oct 2019 4pm Simches 7.240
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DART-seq: an antibody-free method for global m6A detectionNature Methods (2019) Presented by Lu Han (Lee Lab) |
Past Presentations:
16 Apr 2019 4pm Simches 7.240 |
Visualizing DNA folding and RNA in embryos at single-cell resolution
Leslie J. Mateo, Sedona E. Murphy, Antonina Hafner, Isaac S. Cinquini, Carly A. Walker & Alistair N. Boettiger Nature volume 568, pages 49–54 (2019) Presented by Danni Wang (Lee Lab) |
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12 Mar 2019 4pm Simches 7.240 |
Dynamic interplay between enhancer–promoter topology and gene activityHongtao Chen et al., 2018, Nature Genetics, 1296-1303
Transcription-coupled changes in nuclear mobility of mammalian cis-regulatory elementsBo Gu et al., 2018, Science, 1050 -1055Presented by Jongmin Kim (Kingston Lab)
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12 Feb 2019 4pm Simches 7.240 |
Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular SenescenceNojima et al., Molecular Cell Volume 72, Issue 6, P970-984.E7, Nov 2018Presented by: Yongwoo Lee (Lee Lab) |
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11 Dec 2018 4pm Simches 7.240 |
RNA-Dependent Epigenetic Silencing Directs Transcriptional Downregulation Caused by Intronic Repeat ExpansionsEimer H, Sureshkumar S, Singh Yadav A, Kraupner-Taylor C, ... and Balasubramanian SCell, 23 August 2018, 174(5):1095-1105.e11 Presented by: Bojan Bujisic (Lee Lab) |
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13 Nov 2018, 4pm Simches 7.240 |
Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes
Mashtalir N, D'Avino AR, Michel BC, Luo J, ... and Kadoch C Presented by: Jesse Cochrane (Kingston Lab) |
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18 Sep 2018, 4pm Simches 7.240 |
Fluorogenic sensor platform for the histone code using receptors from dynamic combinatorial libraries
Peacor BC, Ramsay CM and Waters ML
Chem Sci., 01 February 2017, 8(2):1422-1428
Presented by: Kathryn Alexa Jackson (Mazitschek Lab)
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17 Apr 2018, 4pm Simches 7.240 |
Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2
Højfeldt JW, Laugesen A, Willumsen BM, Damhofer H, …, Helin K
NSMB, 26 February 2018, 25:225–232 Capturing the onset of PRC2-mediated repressive domain formation
Oksuz O, Narendra V, Lee CH, Descostes N, …, Reinberg D
bioRxiv, 27 February 2018
Presented by: David Colognori (Lee Lab)
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20 Mar 2018, 4pm Simches 7.240 |
Widespread Transcriptional Pausing and Elongation Control at Enhancers
Henriques T, Scruggs BS, Inouye MO, Muse GW, ..., Adelman K
Genes Dev, 29 January 2018
Presented by: Fu-Kai Hsieh (Kinsgston Lab)
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13 Feb 2018, 4pm Simches 7.240 |
Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis
Roe JS1, HWang CI1, Somerville TDD, Milazzo JP, ..., Vakoc CR
Cell, 24 August 2017
Presented by: Christina Ferrer (Mostoslavsky Lab)
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12 Dec 2017, 4pm Simches 7.240 |
Liquid Droplet Formation by HP1α Suggests a Role for Phase Separation in Heterochromatin
Larson AG, Elnatan D, Keenen MM, Trnka MJ, ..., Narlikar GJ |
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14 Nov 2017, 4pm Simches 7.240 |
Multiscale 3D Genome Rewiring during Mouse Neural Development
Bonev B, Mendelson Cohen N, Szabo Q, Fritsch L, ..., Cavalli G |
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10 Oct 2017, 4pm Simches 6.270 |
Evolutionarily Conserved Principles Predict 3D Chromatin Organization
M. Jordan Rowley, Michael H. Nichols, Xiaowen Lyu, ..., Victor G. Corces |
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18 Apr 2017, 4pm Simches 7.240 |
Two independent modes of chromosome organization are revealed by cohesion removal
Schwarzer W., Abdennur N., Goloborodko A .… L. Mirny and F. Spitz |
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14 Feb 2017, 4pm Simches 7.240 |
XACT Noncoding RNA Competes with XIST in the Control of X Chromosome Activity during Human Early Development
Celine Vallot, Catherine Patrat, Amanda J. Collier, ..., Edith Heard, Peter J. Rugg-Gunn, Claire Rougeulle |
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10 Jan 2017, 4pm Simches 7.240 |
Hotair Is Dispensible for Mouse Development
Amândio AR, Necsulea A, Joye E, Mascrez B, and D. Duboule |
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13 Dec 2016, 4pm Simches 7.240 |
Enhancer Control of Transcriptional Bursting
Fukaya T., Lim B. and M. Levine |
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8 Nov 2016, 4pm Simches 7.240 |
A core viral protein binds host nucleosomes to sequester immune danger signals
Daphne C. Avgousti, Christin Herrmann,, Katarzyna Kulej, Neha J. Pancholi, Nikolina Sekulic, Joana Petrescu, Rosalynn C. Molden, Daniel Blumenthal, Andrew J. Paris, Emigdio D. Reyes, Philomena Ostapchuk, Patrick Hearing, Steven H. Seeholzer, G. Scott Worthen, Ben E. Black, Benjamin A. Garcia & Matthew D. Weitzman |
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12 April 2016, 4pm Simches 7.240 |
SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2
Simola DF, Graham RJ, Brady CM, Enzmann BL, Desplan C, Ray A, Zwiebel LJ, Bonasio R, Reinberg D, Liebig J, and SL Berger. |
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8 Mar 2016, 4pm Simches 7.240 |
Epigenetic (re)programming of caste-specific behavior in the ant Camponotus floridanus
Simola DF, Graham RJ, Brady CM, Enzmann BL, Desplan C, Ray A, Zwiebel LJ, Bonasio R, Reinberg D, Liebig J, and SL Berger. |
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6 Feb 2016, 4pm Simches 7.240 |
Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins
Sungyul Lee, Florian Kopp, Tsung-Cheng Chang, Anupama Sataluri, Beibei Chen, Sushama Sivakumar, Hongtao Yu, Yang Xie and Joshua T. Mendell |
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12 Jan 2016, 4pm Simches 7.240 |
Single-Molecule Imaging Reveals a Switch between Spurious and Functional ncRNA Transcription
Tineke L. Lenstra, Antoine Coulon, Carson C. Chow and Daniel R. Larson |
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8 Dec 2015, 4pm Simches 7.240 |
Disruption of histone methylation in developing sperm impairs offspring health transgenerationally.
Siklenka, K., Erkek, S., Godmann, M., Lambrot, R., McGraw, S., Lafleur, C., et al., Science, 6 November 2015 |
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10 Nov 2015, 4pm
Simches 7.240
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Mathieu Tardat, Mareike Albert, Rico Kunzmann, Zichuan Liu, Lilia Kaustov, Raphael Thierry, Shili Duan, Urszula Brykczynska, Cheryl H. Arrowsmith, Antoine H.F.M. Peters. Mol Cell 2 Apr 2015 |
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21 April 2015, 4pm Simches 7.240 |
X Chromosome Reactivation Dynamics Reveal Stages of Reprogramming to Pluripotency (EZproxy link) Pasque V, Tchieu J, Karnik R, Uyeda M, Sadhu Dimashkie A, Case D, Papp B, Bonora G, Patel S, Ho R, Schmidt R, McKee R, Sado T, Tada T, Meissner A, Plath K.D. Cell 18 Dec 2014Presented by: Tom Dial (Lee lab) |
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17 Feb 2015, 4pm (snow day) Simches 7.240 |
Towards a therapy for Angelman syndrome by targeting a long non-coding RNA (EZproxy link) Meng L, Ward AJ, Chun S, Bennett CF, Beaudet AL, Rigo F. Nature 10 December 2014 Presented by: Derek Lessing (Lee Lab) |
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13 Jan 2015, 4pm Simches 7.240 |
Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells (EZproxy link)
Carey, Finley, Cross, Allis, Thompson Wang Nature 10 December 2014 |
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18 Nov 2014, 4pm Simches 7.240 |
H3K27me and PRC2 transmit a memory of repression across generations and during development (EZproxy link) Gaydos, Wang and Strome Science 19 September 2014 Presented by: Arneet Saltzman (Lee Lab) |
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14 Oct 2014, 4pm Simches 7.240 |
Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling (EZproxy link) |
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22 Apr 2014, 4pm (note date change)
Simches 7.240
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Cbx4 governs HIF-1α to potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3 ligase activity (EZproxy link) |
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11 Mar 2014, 4pm, Simches 7.240 |
Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons (EZproxy link) |
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18 Feb 2014, 4pm, (note date change) Simches 7.240 |
Stimulus-triggered fate conversion of somatic cells into pluripotency (EZproxy Link) |
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14 Jan 2014, 4pm, Simches 7.240 |
DNMT1-interacting RNAs block gene-specific DNA methylation (Harvard EZproxy link) |
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10 Dec 2013, 4pm, Simches 4.250 |
Dosage Compensation via Transposable Element Mediated Rewiring of a Regulatory Network (Harvard EZproxy link) |
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12 Nov 2013, 4pm, Simches 7.240 |
A high-resolution map of the three-dimensional chromatin interactome in human cells (Harvard EZproxy link) |
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11 Jun 2013, 4pm, Simches 7.240 |
Asymmetrically modified nucleosomes. (Harvard EZproxy link) |
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14 May 2013, 4pm, Simches 7.240 |
Airn transcriptional overlap, but not its lncRNA products, induces imprinted Igf2r silencing. (Harvard EZproxy link) |
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April 2013, 4pm, Simches 7.240 |
Single-Cell Dynamics of Genome-Nuclear Lamina Interactions. (Harvard EZproxy link) |
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12 Feb 2013, 4pm, Simches 7.240 |
Control of somatic tissue differentiation by the long non-coding RNA TINCR. (Harvard EZproxy link) Kretz et al. Nature 10 Jan 2013 Presented by: Attila Szanto (Lee Lab) |
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8 January 2013, 4pm, Simches 7.240 |
EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent. (Harvard EZproxy link) Xu et al. Science 14 Dec 2012 Presented by: Eric Mendenhall (Bernstein Lab) |
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11 Dec 2012, 4pm, Simches 7.240 |
Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation. (Harvard EZproxy link) Yuan et al. Science 24 Aug 2012 Presented by: Karim Bouazoune (Kingston Lab) |
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11 Nov 2012, 4pm, Simches 7.240 |
Dynamics and Memory of Heterochromatin in Living Cells. (Harvard EZproxy link) Hathaway et al. Cell 22 June 2012 Presented by: John Froberg (Lee Lab) |