Epigenetics Journal Club

The Epigenetics Journal Club at the Simches Research Building is organized by members of the Lee lab, part of the Department of Molecular Biology at Massachusetts General Hospital and the Harvard Medical School Department of Genetics.

Come join us on the second Tuesday of the month!

Free snacks and beverages thanks to our generous sponsor Active Motif.

Upcoming Presentations:

08 Oct

2019

4pm

Simches 7.240

DART-seq: an antibody-free method for global m6A detection

Kate D. Meyer

Nature Methods (2019)

Presented by Lu Han (Lee Lab)

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Past Presentations:

16 Apr 2019 4pm Simches 7.240	Visualizing DNA folding and RNA in embryos at single-cell resolution Leslie J. Mateo, Sedona E. Murphy, Antonina Hafner, Isaac S. Cinquini, Carly A. Walker & Alistair N. Boettiger Nature volume 568, pages 49–54 (2019) Presented by Danni Wang (Lee Lab)
12 Mar 2019 4pm Simches 7.240	Dynamic interplay between enhancer–promoter topology and gene activity Hongtao Chen et al., 2018, Nature Genetics, 1296-1303 Transcription-coupled changes in nuclear mobility of mammalian cis-regulatory elements Bo Gu et al., 2018, Science, 1050 -1055 Presented by Jongmin Kim (Kingston Lab)
12 Feb 2019 4pm Simches 7.240	Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence Nojima et al., Molecular Cell Volume 72, Issue 6, P970-984.E7, Nov 2018 Presented by: Yongwoo Lee (Lee Lab)
11 Dec 2018 4pm Simches 7.240	RNA-Dependent Epigenetic Silencing Directs Transcriptional Downregulation Caused by Intronic Repeat Expansions Eimer H, Sureshkumar S, Singh Yadav A, Kraupner-Taylor C, ... and Balasubramanian S Cell, 23 August 2018, 174(5):1095-1105.e11 Presented by: Bojan Bujisic (Lee Lab)
13 Nov 2018, 4pm Simches 7.240	Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes Mashtalir N, D'Avino AR, Michel BC, Luo J, ... and Kadoch C Cell, 18 October 2018, In press Presented by: Jesse Cochrane (Kingston Lab)
18 Sep 2018, 4pm Simches 7.240	Fluorogenic sensor platform for the histone code using receptors from dynamic combinatorial libraries Peacor BC, Ramsay CM and Waters ML Chem Sci., 01 February 2017, 8(2):1422-1428 Presented by: Kathryn Alexa Jackson (Mazitschek Lab)
17 Apr 2018, 4pm Simches 7.240	Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2 Højfeldt JW, Laugesen A, Willumsen BM, Damhofer H, …, Helin K NSMB, 26 February 2018, 25:225–232 Capturing the onset of PRC2-mediated repressive domain formation Oksuz O, Narendra V, Lee CH, Descostes N, …, Reinberg D bioRxiv, 27 February 2018 Presented by: David Colognori (Lee Lab)
20 Mar 2018, 4pm Simches 7.240	Widespread Transcriptional Pausing and Elongation Control at Enhancers Henriques T, Scruggs BS, Inouye MO, Muse GW, ..., Adelman K Genes Dev, 29 January 2018 Presented by: Fu-Kai Hsieh (Kinsgston Lab)
13 Feb 2018, 4pm Simches 7.240	Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis Roe JS¹, HWang CI¹, Somerville TDD, Milazzo JP, ..., Vakoc CR Cell, 24 August 2017 Presented by: Christina Ferrer (Mostoslavsky Lab)
12 Dec 2017, 4pm Simches 7.240	Liquid Droplet Formation by HP1α Suggests a Role for Phase Separation in Heterochromatin Larson AG, Elnatan D, Keenen MM, Trnka MJ, ..., Narlikar GJ Nature, 13 July 2017 Presented by: Hungoo Lee (Lee Lab)
14 Nov 2017, 4pm Simches 7.240	Multiscale 3D Genome Rewiring during Mouse Neural Development Bonev B, Mendelson Cohen N, Szabo Q, Fritsch L, ..., Cavalli G Cell, 19 October 2017 Presented by: Gilbert Rahme (Bernstein Lab)
10 Oct 2017, 4pm Simches 6.270	Evolutionarily Conserved Principles Predict 3D Chromatin Organization M. Jordan Rowley, Michael H. Nichols, Xiaowen Lyu, ..., Victor G. Corces Mol Cell, 7 September 2017 Presented by: John Froberg (Lee Lab)
18 Apr 2017, 4pm Simches 7.240	Two independent modes of chromosome organization are revealed by cohesion removal Schwarzer W., Abdennur N., Goloborodko A .… L. Mirny and F. Spitz BioRxiv Preprint 15 Dec 2016 Presented by: Andrea Kriz (Lee Lab)
14 Feb 2017, 4pm Simches 7.240	XACT Noncoding RNA Competes with XIST in the Control of X Chromosome Activity during Human Early Development Celine Vallot, Catherine Patrat, Amanda J. Collier, ..., Edith Heard, Peter J. Rugg-Gunn, Claire Rougeulle Cell Stem Cell, 5 January 2017 Presented by: Rodrigo Aguilar (Lee Lab)
10 Jan 2017, 4pm Simches 7.240	Hotair Is Dispensible for Mouse Development Amândio AR, Necsulea A, Joye E, Mascrez B, and D. Duboule Plos Genetics, 15 Dec 2016 Presented by: Aaron Plys (Kingston Lab)
13 Dec 2016, 4pm Simches 7.240	Enhancer Control of Transcriptional Bursting Fukaya T., Lim B. and M. Levine Cell, 14 July 2016 Presented by: Jongmin Kim (Kingston Lab)
8 Nov 2016, 4pm Simches 7.240	A core viral protein binds host nucleosomes to sequester immune danger signals Daphne C. Avgousti, Christin Herrmann,, Katarzyna Kulej, Neha J. Pancholi, Nikolina Sekulic, Joana Petrescu, Rosalynn C. Molden, Daniel Blumenthal, Andrew J. Paris, Emigdio D. Reyes, Philomena Ostapchuk, Patrick Hearing, Steven H. Seeholzer, G. Scott Worthen, Ben E. Black, Benjamin A. Garcia & Matthew D. Weitzman Nature, 7 July 2016 Presented by: Mattia Lion (Oettinger Lab)
12 April 2016, 4pm Simches 7.240	SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2 Simola DF, Graham RJ, Brady CM, Enzmann BL, Desplan C, Ray A, Zwiebel LJ, Bonasio R, Reinberg D, Liebig J, and SL Berger. Nature Medicine, 9 November 2015 Presented by: Behfar Ardehali (Kingston Lab)
8 Mar 2016, 4pm Simches 7.240	Epigenetic (re)programming of caste-specific behavior in the ant Camponotus floridanus Simola DF, Graham RJ, Brady CM, Enzmann BL, Desplan C, Ray A, Zwiebel LJ, Bonasio R, Reinberg D, Liebig J, and SL Berger. Science, 1 January 2016 Presented by: Lieselot Carrette (Lee Lab)
6 Feb 2016, 4pm Simches 7.240	Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins Sungyul Lee, Florian Kopp, Tsung-Cheng Chang, Anupama Sataluri, Beibei Chen, Sushama Sivakumar, Hongtao Yu, Yang Xie and Joshua T. Mendell Cell, 14 January 2016 Presented by: Lin Yang (Lee Lab)
12 Jan 2016, 4pm Simches 7.240	Single-Molecule Imaging Reveals a Switch between Spurious and Functional ncRNA Transcription Tineke L. Lenstra, Antoine Coulon, Carson C. Chow and Daniel R. Larson Mol Cell, 19 November 2015 Presented by: Eric Aeby (Lee Lab)
8 Dec 2015, 4pm Simches 7.240	Disruption of histone methylation in developing sperm impairs offspring health transgenerationally. Siklenka, K., Erkek, S., Godmann, M., Lambrot, R., McGraw, S., Lafleur, C., et al., Science, 6 November 2015 Presented by: Derek Lessing (Lee Lab)
10 Nov 2015, 4pm Simches 7.240	Cbx2 Targets PRC1 to Constitutive Heterochromatin in Mouse Zygotes in a Parent-of-Origin-Dependent Manner (EZproxy link) Mathieu Tardat, Mareike Albert, Rico Kunzmann, Zichuan Liu, Lilia Kaustov, Raphael Thierry, Shili Duan, Urszula Brykczynska, Cheryl H. Arrowsmith, Antoine H.F.M. Peters. Mol Cell 2 Apr 2015 Presented by: Arneet Saltzman (Lee lab)
21 April 2015, 4pm Simches 7.240	X Chromosome Reactivation Dynamics Reveal Stages of Reprogramming to Pluripotency (EZproxy link) Pasque V, Tchieu J, Karnik R, Uyeda M, Sadhu Dimashkie A, Case D, Papp B, Bonora G, Patel S, Ho R, Schmidt R, McKee R, Sado T, Tada T, Meissner A, Plath K.D. Cell 18 Dec 2014 Presented by: Tom Dial (Lee lab)
17 Feb 2015, 4pm (snow day) Simches 7.240	Towards a therapy for Angelman syndrome by targeting a long non-coding RNA (EZproxy link) Meng L, Ward AJ, Chun S, Bennett CF, Beaudet AL, Rigo F. Nature 10 December 2014 Presented by: Derek Lessing (Lee Lab)
13 Jan 2015, 4pm Simches 7.240	Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells (EZproxy link) Carey, Finley, Cross, Allis, Thompson Wang Nature 10 December 2014 Presented by: Brian Liau (Bernstein Lab)
18 Nov 2014, 4pm Simches 7.240	H3K27me and PRC2 transmit a memory of repression across generations and during development (EZproxy link) Gaydos, Wang and Strome Science 19 September 2014 Presented by: Arneet Saltzman (Lee Lab)
14 Oct 2014, 4pm Simches 7.240	Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling (EZproxy link) Herz, Morgan et al. Science 29 August 2014 Presented by: Jean-Pierre Etchegaray (Mostoslavsky Lab)
22 Apr 2014, 4pm (note date change) Simches 7.240	Cbx4 governs HIF-1α to potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3 ligase activity (EZproxy link) Li et al. Cancer Cell 13 January 2014 Presented by: Michael Rosenberg (Lee Lab)
11 Mar 2014, 4pm, Simches 7.240	Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons (EZproxy link) Wapinski, Vierbuchen et al. Cell 24 October 2013 Presented by: Dan Tarjan (Bernstein Lab)
18 Feb 2014, 4pm, (note date change) Simches 7.240	Stimulus-triggered fate conversion of somatic cells into pluripotency (EZproxy Link) & Bidirectional developmental potential in reprogrammed cells with acquired pluripotency (EZproxy Link) Obokata et al. Nature 30 Jan 2014 Presented by: Derek Lessing (Lee lab)
14 Jan 2014, 4pm, Simches 7.240	DNMT1-interacting RNAs block gene-specific DNA methylation (Harvard EZproxy link) Di Ruscio et al. Nature 09 October 2013 Presented by: Chen-Yu Wang (Lee lab)
10 Dec 2013, 4pm, Simches 4.250	Dosage Compensation via Transposable Element Mediated Rewiring of a Regulatory Network (Harvard EZproxy link) Ellison and Bachtrog Science 15 November 2013 Presented by: Arneet Saltzman (Lee lab)
12 Nov 2013, 4pm, Simches 7.240	A high-resolution map of the three-dimensional chromatin interactome in human cells (Harvard EZproxy link) Jin et al. Nature 20 October 2013 Presented by: Rusty Ryan (Bernstein Lab)
11 Jun 2013, 4pm, Simches 7.240	Asymmetrically modified nucleosomes. (Harvard EZproxy link) Voigt et al. Cell 28 September 2012 Presented by: Efrat Shema-Yaacoby (Bernstein Lab)
14 May 2013, 4pm, Simches 7.240	Airn transcriptional overlap, but not its lncRNA products, induces imprinted Igf2r silencing. (Harvard EZproxy link) Latos et al. Science 14 Dec 2012 Presented by: Michael Rosenberg (Lee Lab)
April 2013, 4pm, Simches 7.240	Single-Cell Dynamics of Genome-Nuclear Lamina Interactions. (Harvard EZproxy link) Kind et al. Cell 21 March 2013 Presented by: Arneet Saltzman (Lee Lab)
12 Feb 2013, 4pm, Simches 7.240	Control of somatic tissue differentiation by the long non-coding RNA TINCR. (Harvard EZproxy link) Kretz et al. Nature 10 Jan 2013 Presented by: Attila Szanto (Lee Lab)
8 January 2013, 4pm, Simches 7.240	EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent. (Harvard EZproxy link) Xu et al. Science 14 Dec 2012 Presented by: Eric Mendenhall (Bernstein Lab)
11 Dec 2012, 4pm, Simches 7.240	Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation. (Harvard EZproxy link) Yuan et al. Science 24 Aug 2012 Presented by: Karim Bouazoune (Kingston Lab)
11 Nov 2012, 4pm, Simches 7.240	Dynamics and Memory of Heterochromatin in Living Cells. (Harvard EZproxy link) Hathaway et al. Cell 22 June 2012 Presented by: John Froberg (Lee Lab)

at the Simches Research Building, MGH

The Epigenetics Journal Club at the Simches Research Building is organized by members of the Lee lab, part of the Department of Molecular Biology at Massachusetts General Hospital and the Harvard Medical School Department of Genetics.

Come join us on the second Tuesday of the month!

Free snacks and beverages thanks to our generous sponsor Active Motif.

Upcoming Presentations:

Past Presentations:

Hongtao Chen et al., 2018, Nature Genetics, 1296-1303

Bo Gu et al., 2018, Science, 1050 -1055

Nojima et al., Molecular Cell Volume 72, Issue 6, P970-984.E7, Nov 2018

Presented by: Yongwoo Lee (Lee Lab)

Eimer H, Sureshkumar S, Singh Yadav A, Kraupner-Taylor C, ... and Balasubramanian S