The Epigenetics Journal Club at the Simches Research Building is organized by members of the Lee lab, part of the Department of Molecular Biology at Massachusetts General Hospital and the Harvard Medical School Department of Genetics.

Come join us on the second Tuesday of the month!

Free snacks and beverages thanks to our generous sponsor Active Motif.

Upcoming Presentations:

08 Oct



Simches 7.240


DART-seq: an antibody-free method for global m6A detection

Kate D. Meyer

Nature Methods (2019)

Presented by Lu Han (Lee Lab)

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Past Presentations:

16 Apr 2019


Simches 7.240

Visualizing DNA folding and RNA in embryos at single-cell resolution


Leslie J. MateoSedona E. MurphyAntonina HafnerIsaac S. CinquiniCarly A. Walker & Alistair N. Boettiger 

Nature volume 568, pages 49–54 (2019)

Presented by Danni Wang (Lee Lab)


12 Mar 2019


Simches 7.240

Dynamic interplay between enhancer–promoter topology and gene activity

Hongtao Chen et al., 2018, Nature Genetics, 1296-1303


Transcription-coupled changes in nuclear mobility of mammalian cis-regulatory elements

Bo Gu et al., 2018, Science, 1050 -1055

Presented by Jongmin Kim (Kingston Lab)



12 Feb 2019


Simches 7.240

Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence

Nojima et al., Molecular Cell  Volume 72, Issue 6, P970-984.E7, Nov 2018  

Presented by: Yongwoo Lee (Lee Lab)


11 Dec 2018


Simches 7.240

RNA-Dependent Epigenetic Silencing Directs Transcriptional Downregulation Caused by Intronic Repeat Expansions

Eimer H, Sureshkumar S, Singh Yadav A, Kraupner-Taylor C, ... and Balasubramanian S

Cell, 23 August 2018, 174(5):1095-1105.e11

Presented by: Bojan Bujisic (Lee Lab)


13 Nov 2018, 4pm

Simches 7.240

Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes

Mashtalir N, D'Avino AR, Michel BC, Luo J, ... and Kadoch C
Cell, 18 October 2018, In press

Presented by: Jesse Cochrane (Kingston Lab)


18 Sep 2018, 4pm

Simches 7.240

Fluorogenic sensor platform for the histone code using receptors from dynamic combinatorial libraries

Peacor BC, Ramsay CM and Waters ML
Chem Sci., 01 February 2017, 8(2):1422-1428
Presented by: Kathryn Alexa Jackson (Mazitschek Lab)

17 Apr 2018, 4pm

Simches 7.240

Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2

Højfeldt JW, Laugesen A, Willumsen BM, Damhofer H, …, Helin K
NSMB, 26 February 2018, 25:225–232

Capturing the onset of PRC2-mediated repressive domain formation

Oksuz O, Narendra V, Lee CH, Descostes N, …, Reinberg D
bioRxiv, 27 February 2018
Presented by: David Colognori (Lee Lab)

20 Mar 2018, 4pm

Simches 7.240

Widespread Transcriptional Pausing and Elongation Control at Enhancers

Henriques T, Scruggs BS, Inouye MO, Muse GW, ..., Adelman K
Genes Dev, 29 January 2018
Presented by: Fu-Kai Hsieh (Kinsgston Lab)

13 Feb 2018, 4pm

Simches 7.240

Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis

Roe JS1, HWang CI1, Somerville TDD, Milazzo JP, ..., Vakoc CR
Cell, 24 August 2017
Presented by: Christina Ferrer (Mostoslavsky Lab)

12 Dec 2017, 4pm

Simches 7.240

Liquid Droplet Formation by HP1α Suggests a Role for Phase Separation in Heterochromatin

Larson AG, Elnatan D, Keenen MM, Trnka MJ, ..., Narlikar GJ
Nature, 13 July 2017
Presented by: Hungoo Lee (Lee Lab)


14 Nov 2017, 4pm

Simches 7.240

Multiscale 3D Genome Rewiring during Mouse Neural Development

Bonev B, Mendelson Cohen N, Szabo Q, Fritsch L, ..., Cavalli G
Cell, 19 October 2017
Presented by: Gilbert Rahme (Bernstein Lab)


10 Oct 2017, 4pm

Simches 6.270

Evolutionarily Conserved Principles Predict 3D Chromatin Organization

M. Jordan Rowley, Michael H. Nichols, Xiaowen Lyu, ..., Victor G. Corces
Mol Cell, 7 September 2017

Presented by: John Froberg (Lee Lab)


18 Apr 2017, 4pm

Simches 7.240

Two independent modes of chromosome organization are revealed by cohesion removal

Schwarzer W., Abdennur N., Goloborodko A .… L. Mirny and F. Spitz
BioRxiv Preprint 15 Dec 2016
Presented by: Andrea Kriz (Lee Lab)


14 Feb 2017, 4pm

Simches 7.240

XACT Noncoding RNA Competes with XIST in the Control of X Chromosome Activity during Human Early Development

Celine Vallot, Catherine Patrat, Amanda J. Collier, ..., Edith Heard, Peter J. Rugg-Gunn, Claire Rougeulle
Cell Stem Cell, 5 January 2017

Presented by: Rodrigo Aguilar (Lee Lab)


10 Jan 2017, 4pm

Simches 7.240

Hotair Is Dispensible for Mouse Development

Amândio AR, Necsulea A, Joye E, Mascrez B, and D. Duboule
Plos Genetics, 15 Dec 2016
Presented by: Aaron Plys (Kingston Lab)


13 Dec 2016, 4pm

Simches 7.240

Enhancer Control of Transcriptional Bursting

Fukaya T., Lim B. and M. Levine
Cell, 14 July 2016
Presented by: Jongmin Kim (Kingston Lab)


8 Nov 2016, 4pm

Simches 7.240

A core viral protein binds host nucleosomes to sequester immune danger signals

Daphne C. Avgousti, Christin Herrmann,, Katarzyna Kulej, Neha J. Pancholi, Nikolina Sekulic, Joana Petrescu, Rosalynn C. Molden, Daniel Blumenthal, Andrew J. Paris, Emigdio D. Reyes, Philomena Ostapchuk, Patrick Hearing, Steven H. Seeholzer, G. Scott Worthen, Ben E. Black, Benjamin A. Garcia & Matthew D. Weitzman
Nature, 7 July 2016
Presented by: Mattia Lion (Oettinger Lab)


12 April 2016, 4pm

Simches 7.240

SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2

Simola DF, Graham RJ, Brady CM, Enzmann BL, Desplan C, Ray A, Zwiebel LJ, Bonasio R, Reinberg D, Liebig J, and SL Berger.
Nature Medicine, 9 November 2015

Presented by: Behfar Ardehali (Kingston Lab)

8 Mar 2016, 4pm

Simches 7.240

Epigenetic (re)programming of caste-specific behavior in the ant Camponotus floridanus

Simola DF, Graham RJ, Brady CM, Enzmann BL, Desplan C, Ray A, Zwiebel LJ, Bonasio R, Reinberg D, Liebig J, and SL Berger.
Science, 1 January 2016

Presented by: Lieselot Carrette (Lee Lab)

6 Feb 2016, 4pm

Simches 7.240

Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins

Sungyul Lee, Florian Kopp, Tsung-Cheng Chang, Anupama Sataluri, Beibei Chen, Sushama Sivakumar, Hongtao Yu, Yang Xie and Joshua T. Mendell
Cell, 14 January 2016

Presented by: Lin Yang (Lee Lab)

12 Jan 2016, 4pm

Simches 7.240

Single-Molecule Imaging Reveals a Switch between Spurious and Functional ncRNA Transcription

Tineke L. Lenstra, Antoine Coulon, Carson C. Chow and Daniel R. Larson
Mol Cell, 19 November 2015

Presented by: Eric Aeby (Lee Lab)

8 Dec 2015, 4pm

Simches 7.240

Disruption of histone methylation in developing sperm impairs offspring health transgenerationally.

Siklenka, K., Erkek, S., Godmann, M., Lambrot, R., McGraw, S., Lafleur, C., et al., Science, 6 November 2015
Presented by: Derek Lessing (Lee Lab)

10 Nov 2015, 4pm


Simches 7.240


Cbx2 Targets PRC1 to Constitutive Heterochromatin in Mouse Zygotes in a Parent-of-Origin-Dependent Manner (EZproxy link) 

Mathieu Tardat, Mareike Albert, Rico Kunzmann, Zichuan Liu, Lilia Kaustov, Raphael Thierry, Shili Duan, Urszula Brykczynska, Cheryl H. Arrowsmith, Antoine H.F.M. Peters. Mol Cell 2 Apr 2015
Presented by: Arneet Saltzman (Lee lab)

21 April 2015, 4pm

Simches 7.240

X Chromosome Reactivation Dynamics Reveal Stages of Reprogramming to Pluripotency (EZproxy link) 

Pasque V, Tchieu J, Karnik R, Uyeda M, Sadhu Dimashkie A, Case D, Papp B, Bonora G, Patel S, Ho R, Schmidt R, McKee R, Sado T, Tada T, Meissner A, Plath K.D. Cell 18 Dec 2014
Presented by: Tom Dial (Lee lab)

17 Feb 2015, 4pm (snow day)

Simches 7.240

Towards a therapy for Angelman syndrome by targeting a long non-coding RNA (EZproxy link) 
Meng L, Ward AJ, Chun S, Bennett CF, Beaudet AL, Rigo F. Nature 10 December 2014
Presented by: Derek Lessing (Lee Lab)

13 Jan 2015, 4pm

Simches 7.240

Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells (EZproxy link)

Carey, Finley, Cross, Allis, Thompson Wang Nature 10 December 2014
Presented by: Brian Liau (Bernstein Lab)

18 Nov 2014, 4pm

Simches 7.240

H3K27me and PRC2 transmit a memory of repression across generations and during development (EZproxy link)
Gaydos, Wang and Strome Science 19 September 2014
Presented by: Arneet Saltzman (Lee Lab)

14 Oct 2014, 4pm

Simches 7.240

Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling (EZproxy link)
Herz, Morgan et al. Science 29 August 2014
Presented by: Jean-Pierre Etchegaray (Mostoslavsky Lab)

22 Apr 2014, 4pm (note date change)


Simches 7.240


Cbx4 governs HIF-1α to potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3 ligase activity (EZproxy link)
Li et al. Cancer Cell 13 January 2014
Presented by: Michael Rosenberg (Lee Lab)

11 Mar 2014, 4pm, Simches 7.240

Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons (EZproxy link)
Wapinski, Vierbuchen et al. Cell 24 October 2013
Presented by: Dan Tarjan (Bernstein Lab)

18 Feb 2014, 4pm, (note date change)

Simches 7.240

Stimulus-triggered fate conversion of somatic cells into pluripotency (EZproxy Link)
Bidirectional developmental potential in reprogrammed cells with acquired pluripotency (EZproxy Link)

Obokata et al. Nature 30 Jan 2014
Presented by: Derek Lessing (Lee lab)

14 Jan 2014, 4pm, Simches 7.240

DNMT1-interacting RNAs block gene-specific DNA methylation (Harvard EZproxy link)
Di Ruscio et al. Nature 09 October 2013
Presented by: Chen-Yu Wang (Lee lab)

10 Dec 2013, 4pm, Simches 4.250

Dosage Compensation via Transposable Element Mediated Rewiring of a Regulatory Network (Harvard EZproxy link)
Ellison and Bachtrog Science 15 November 2013
Presented by: Arneet Saltzman (Lee lab)

12 Nov 2013, 4pm, Simches 7.240

A high-resolution map of the three-dimensional chromatin interactome in human cells (Harvard EZproxy link)
Jin et al. Nature 20 October 2013

Presented by: Rusty Ryan (Bernstein Lab)

11 Jun 2013, 4pm, Simches 7.240

Asymmetrically modified nucleosomes. (Harvard EZproxy link)
Voigt et al. Cell 28 September 2012

Presented by: Efrat Shema-Yaacoby (Bernstein Lab)

14 May 2013, 4pm, Simches 7.240

Airn transcriptional overlap, but not its lncRNA products, induces imprinted Igf2r silencing. (Harvard EZproxy link)
Latos et al. Science 14 Dec 2012

Presented by: Michael Rosenberg (Lee Lab)

April 2013, 4pm, Simches 7.240

Single-Cell Dynamics of Genome-Nuclear Lamina Interactions. (Harvard EZproxy link)
Kind et al. Cell 21 March 2013

Presented by: Arneet Saltzman (Lee Lab)

12 Feb 2013, 4pm, Simches 7.240 Control of somatic tissue differentiation by the long non-coding RNA TINCR. (Harvard EZproxy link)
Kretz et al. Nature 10 Jan 2013

Presented by: Attila Szanto (Lee Lab)
8 January 2013, 4pm, Simches 7.240 EZH2 oncogenic activity in castration-resistant prostate cancer cells is Polycomb-independent. (Harvard EZproxy link)
Xu et al. Science 14 Dec 2012

Presented by: Eric Mendenhall (Bernstein Lab)
11 Dec 2012, 4pm, Simches 7.240 Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation. (Harvard EZproxy link)
Yuan et al. Science 24 Aug 2012

Presented by: Karim Bouazoune (Kingston Lab)
11 Nov 2012, 4pm, Simches 7.240 Dynamics and Memory of Heterochromatin in Living Cells. (Harvard EZproxy link)
Hathaway et al. Cell 22 June 2012

Presented by: John Froberg (Lee Lab)