The Lab in Brief
NOTICE TO HARVARD UNDERGRADUATES:
WE CURRENTLY HAVE LAB RESEARCH OPPORTUNITIES FOR HARVARD UNDERGRADUATES STARTING FALL 2023. INTERESTED STUDENTS SHOULD CONSIDER ENROLLING IN HEB1480 IN FALL 2023, AND SHOULD EMAIL TERENCE CAPELLINI (tcapellini@fas.harvard.edu) FOR MORE INFORMATION. CAPELLINI OFFICE HOURS ARE MONDAYS 1-2PM
NOTICE TO PROSPECTIVE POST-DOCTORAL FELLOWS:
WE ARE NOW ACCEPTING POST-DOC APPLICATIONS FOR START THIS WINTER. PLEASE SEE "In The News" Tab.
The Laboratory and Nearby Resources:
We have a new state-of-the-art lab located in the Peabody Museum at Harvard University, which includes ~8-10 workstations for technicians, undergraduate and graduate students, post-doctoral fellows, and visiting scholars. Our space also contains separate rooms for Biohazard Level II cell culture, microscopy, bacterial incubation and centrifugation, gel imaging, and lab kitchen work. Each room contains the necessary molecular, cell, developmental, genetics, and imaging equipment for a fully functioning laboratory. My office is down the hall in the HEB department, which has numerous teaching classrooms, libraries, and conference rooms. More broadly, we have access to facilities within the Biolabs building next door. These facilities include: The Bauer Core, which owns multiple real-time PCR machines, bioanalyzers, luminometers, fluorometers, DNA sequencers, among a variety of other equipment; The Harvard Center for Biological Imaging, which contains cutting-edge Carl Zeiss microscopes; The Genome Modification Facility, with the ability to perform the DNA micro-injection and gene targeting techniques we use in the lab; and the VWR stock room providing immediate access to laboratory supplies. For our bioinformatics studies, we have computational support in Resource Computing, possessing 55,000 processors and >12PB of shared storage, one of the largest clusters in the Boston area. This center is integrated with the Bauer Core for effective processing of experimental data. We also have two mouse rooms located in the Harvard BRI facility adjacent to the Peabody, which is a modern animal facility for clean "pathogen-free" work.
We are an NIH and NSF funded laboratory:
NIH R01 (NIAMS): Molecular architecture of the human knee joint and pelvis at single cell resolution – 9/1/2022-8/31/2027
NIH R01 (NIAMS): Uncovering the Genetic Mechanisms Behind Joint-Specific Osteoarthritis - 3/31/18-Present
NSF (Anthropology): Interrogating Positively Selected Introgressed Variants in Modern Human Genomes for Regulatory Functions – 10/01/2020-Present
Additional Funding from Harvard Dean's Competitive Award, Milton Fund; Impetus Fund