Citation:
Chen H, Capellini TD, Schoor M, Mortlock D, Reddi H, Kingsley DM. Heads, Shoulders, Elbows, Knees, and Toes: Modular Gdf5 Enhancers Control Different Joints in the Vertebrate Skeleton. Plos Genetics. 2016;Nov 30;12 (11) ::e1006454.
Developmental and Evolutionary Genetics Lab
Terence Capellini, PI - Harvard University; and the Broad Institute of MIT and Harvard
53C-D, Peabody Museum
11 Divinity Ave. Cambridge MA
Recent Publications
- Regulatory dissection of the severe COVID-19 risk locus introgressed by Neanderthals
- Identification of IGF2BP1-related lncRNA-miRNA-mRNA network in goat skeletal muscle satellite cells
- A spatio-temporally constrained gene regulatory network directed by PBX1/2 acquires limb patterning specificity via HAND2
- Lineage-specific differences and regulatory networks governing human chondrocyte development
- Detection of Neanderthal Adaptively Introgressed Genetic Variants That Modulate Reporter Gene Expression in Human Immune Cells
- Human and African ape myosin heavy chain content and the evolution of hominin skeletal muscle
- Interspecies transcriptomics identify genes that underlie disproportionate foot growth in jerboas
- Epigenetics as a mediator of genetic risk in osteoarthritis: role during development, homeostasis, aging, and disease progression
- Author Correction: Joint disease-specificity at the regulatory base-pair level
- The functional and evolutionary impacts of human-specific deletions in conserved elements
- Intronic regulation of SARS-CoV-2 receptor (ACE2) expression mediated by immune signaling and oxidative stress pathways
- Molecular mechanism of synovial joint site specification and induction in developing vertebrate limbs
- The developmental impacts of natural selection on human pelvic morphology
- The Notch-mediated circuitry in the evolution and generation of new cell lineages: the tooth model
- Shifting epigenetic contexts influence regulatory variation and disease risk
- Joint disease-specificity at the regulatory base-pair level
- Genome-wide association of phenotypes based on clustering patterns of hand osteoarthritis identify as novel osteoarthritis gene
- Bi-fated tendon-to-bone attachment cells are regulated by shared enhancers and KLF transcription factors
- Single Cell Omics for Musculoskeletal Research
- Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responses
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