@article {1595006,
	title = {Impaired executive function exacerbates neural markers of posttraumatic stress disorder},
	journal = {Psychological Medicine},
	year = {2021},
	pages = {1-14},
	abstract = {
	Background



	A major obstacle in understanding and treating posttraumatic stress disorder (PTSD) is its clinical and neurobiological heterogeneity. To address this barrier, the field has become increasingly interested in identifying subtypes of PTSD based on dysfunction in neural networks alongside cognitive impairments that may underlie the development and maintenance of symptoms. The current study aimed to determine if subtypes of PTSD, based on normative-based cognitive dysfunction across multiple domains, have unique neural network signatures.



	Methods



	In a sample of 271 veterans (90\% male) that completed both neuropsychological testing and resting-state fMRI, two complementary, whole-brain functional connectivity analyses explored the link between brain functioning, PTSD symptoms, and cognition.



	Results



	At the network level, PTSD symptom severity was associated with reduced negative coupling between the limbic network (LN) and frontal-parietal control network (FPCN), driven specifically by the dorsolateral prefrontal cortex and amygdala Hubs of Dysfunction. Further, this relationship was uniquely moderated by executive function (EF). Specifically, those with PTSD and impaired EF had the strongest marker of LN-FPCN dysregulation, while those with above-average EF did not exhibit PTSD-related dysregulation of these networks.



	Conclusion



	These results suggest that poor executive functioning, alongside LN-FPCN dysregulation, may represent a neurocognitive subtype of PTSD.

},
	url = {https://doi.org/10.1017/S0033291721000842},
	author = {Jagger-Rickels, Audreyana and Anna Stumps and David Rothlein and Park, Hannah and Fortenbaugh, Francesca and Agnieszka Zuberer and Fonda, Jennifer and Fortier, Catherine and DeGutis, Joseph and Milberg, William and McGlinchey, Regina and Esterman, Michael}
}
