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Members

Sam Berry Photo

Sam Berry

Graduate Student
sberry@g.harvard.edu
Heather's Photo

Heather Frank

Graduate Student
hfrank@g.harvard.edu
Camille Headshot

Camille Freedman

Undergraduate Student
camillefreedman@college.harvard.edu
Rachelle Gaudet

Rachelle Gaudet

Professor of Molecular and Cellular Biology
gaudet@fas.harvard.edu
p: 617-495-5616
Jorge Headshot

Jorge Guerra

Undergraduate Student
jorgeguerra@college.harvard.edu
Janny Liao headshot

Janny Liao

Undergraduate Student
jannyliao@college.harvard.edu
E. May

Elizabeth May

Graduate Student
emay@g.harvard.edu
Robin headshot

Robin Pan

Undergraduate Student
rpan@college.harvard.edu
Shamayeeta Ray

Shamayeeta Ray

Postdoctoral Fellow
shamayeeta_ray@fas.harvard.edu
Jose Velilla

José Velilla

Graduate Student
josevelilla@g.harvard.edu

Sanket Walujkar

Postdoctoral Fellow
swalujkar@fas.harvard.edu
Amber Headshot

Amber Wei

Undergraduate Student
amberwei@college.harvard.edu
G.Zavala

Gerardo Zavala

Graduate Student
gzavala@fas.harvard.edu

81159e92459c6de2fcc18a453fb3abfc

 

Alumni

 

Trainees

Dates (Current position)

Project(s) and Other Notes


 

PhD Students

Erik Procko

(MCB)

2003-2009

(Assistant Professor U. of Illinois, Urbana-Champaign)

Thesis title: General Mechanisms for ABC Transporters revealed by the Transporter associated with Antigen Processing

Additional project: Role of TRPV1 ankyrin repeats in TRPV1 temperature sensitivity and calmodulin interactions

Ruiqi Rachel Wang

(Chem Bio)

2007-2009

(PhD 2012 with Tom Walz, Harvard Medical School; Assistant Director at Ntuitive Pt Ltd)

Biochemical characterization of the TRPV ankyrin repeats - the TRPV3 and TRPV4 ankyrin repeats bind ATP and calmodulin

Luciann L. Cuenca (BBS)

2009-2014 (PhD 2019 from HMS; Technology Specialist at Lando & Anastasi, LLP)

Structural and functional studies of TRPV1 (NIH F31 Fellow)

Lukas Bane (MCO)

2011-2015 (Strategic Growth Associate, D.E. Shaw Research)

Thesis title: Structural and Functional Studies into Nramp Divalent Metal Transporter Mechanisms

Monique Brewster (MCO)

2011-2016 (Preceptor, Harvard University)

Structural studies of the cytoplasmic domains of TRPA1 (NIH F31 Fellow)

Sriram Srikant (EPB)

2012-2019 (Postdoc, MIT)

Structure and evolution of ABCB transporters (HHMI Fellow)

Kenneth Skinner (Chemical Biology)

2012-2017 (Fellow, Vertex Pharmaceuticals)

Propofol binding by the TRPA1 ion channel (NSF and Ford Fellow)

Aaron Bozzi (MCO)

2013-2018 (Postdoc, MIT)

Functional studies of NRAMP transporters

John Nicoludis (Chemistry)

2013-2018 (Postdoc, UCSF)

Structural studies of clustered protocadherins and MsrPQ (NDSEG Fellow)

S. E. Chapman (MCO)

2019-2020 (LOA)

Structural studies of insect sensory receptors (QBio Fellow)


 

Postdoctoral Fellows

Xiangshu Jin

2003-2006

(Assistant Professor, Michigan State University)

Structure determination of the TRPV1 and TRPV2 ankyrin repeat domains

Christopher Phelps

2003-2009

(Principal Scientist, GlaxoSmithKline)

Functional and Structural Studies of TRPM8

Structure of the TRPV6 ankyrin repeats

Functional studies of TRPV channels

Wilhelm Weihofen

2005-2011

(Crystallography Group Leader, Novartis)

Structural studies of Nramp transporters

Structures of pathogen deubiquitinating enzymes (collaboration with H.L. Ploegh)

Structures of cadherins important in hearing (collaboration with D.P. Corey)

Sze Yi Lau

2008-2012

(Postdoc, A*STAR, Singapore)

Structural determinants of TRPV1 and calmodulin interaction

Functional studies of TRPM8

Marcos Sotomayor

2008-2013

(Assistant Professor, Ohio State University)

Structure and molecular dynamics of the hair cell tip link cadherins (collaboration with D.P. Corey) *HHW Fellow* *K99*

Ahmet Vakkasoglu

2009-2015 (Scientist, Momenta)

Structure and function of the TAP transporter

Alex Peralvarez-Marin

2010-2011

(Autonomous University of Barcelona, Spain)

Production of TRPV channels for structural studies *Marie Curie Fellow*

Ute Hellmich

2012-2014 (Assistant Professor, Johannes Gutenberg-Universität Mainz, Germany

TRPV channel structural studies *EMBO Fellow*

Jeffrey McArthur

2013-2016

(Research Fellow, University of Wollongong, Australia)

Conformational changes in TRPV1

Christina Zimanyi

2013-2016 (Scientist, NY Structural Biology Center)

TRPA1 activation by electrophiles *Jane Coffin Childs Fellow*

Research Associates

Polina V. Lishko

2005-2007

(Assistant Professor, Berkeley)

Establishing Electrophysiology

Developing a cysteine-less TRPV1 protein

Role of the TRPV1 ankyrin repeats in TRPV1 function

Hitoshi Inada

2008-2012

(Lecturer, Tohoku University, Japan)

Expression of TRP channels in insect cells and yeast; evaluation using fluorescence size exclusion chromatography

Crystallization and structure determination of TRPV and TRPM channel domains

Postbaccalaureate Students

Michael Gutierrez

2019-2020

Structural and biochemical investigation of Nramp substrate-binding site diversity

Undergraduates

   

Aaron Huang

2002-2004

Toward a TAP1/TAP2 nucleotide-binding domain heterodimer

Tiffany Hsieh

2002-2004

(MD, Columbia University)

Expression of the TRPV1 C-terminal domain

David Sola-Del Valle

2004-2005

(MD ’10, Columbia University, Ophthalmologist)

Thesis title: Structure-function studies of TRPA1, a thermo- and mechano-sensitive ion channel

Hoopes Prize

Shelly S. Choo

2004-2006

(MD ’11, Johns Hopkins University)

Thesis title: Structural and Biochemical Studies of the N-Terminal Region of the Temperature-Sensing TRPV Ion Channels

Hoopes and Henderson Prizes

Co-author, JBC 2010; Nature Genetics 2010

Robert J. Huang

2005-2007

(MD ’11, Duke University)

Thesis title: Structural and Functional Studies of the Ankyrin Repeats of TRPV Ion Channels

Co-author, Biochemistry 2008

Samer Haidar

2005-2009

(MBA+MS in Mechanical Engineering, MIT)

Engineering Design Project title: Inducing Dimeric Interactions Using Leucine Zippers

(HHMI program)

Albert Li

2006-2009

(MD ’13, NYU; Asisstant Professor in Ophthalmology University of Maryland)

Thesis title: Structural Studies of TRPV1 Activation by Capsaicin

(Hoopes Prize, PRISE Fellow)

Vi Vu

2007-2009

(VES concentration, class of 2010)

Interaction of TRPV1 with calmodulin

(HHMI program, PRISE Fellow)

Alejandra Beristain-Barajas

2007-2010

(UC Davis Medical School)

Thesis title: Exploring the Molecular Mechanisms of Pain: Structural and Biochemical Studies on Nociceptor Channel TRPA1, Ankyrin Repeat Domain

(PRISE Fellow)

Tianyi Zhu

Summer 2006

Expression and purification of bacterial Nramp transporters

Anne McCabe

2007-2011

(PhD, Princeton, Postdoc, Tufts University)

Thesis title: Studying the ion permeation pathway of divalent metal transporter

NRAMP using site-directed mutagenesis

(PRISE Fellow)

Co-author, PNAS 2016, JBC 2020

Ahad Waraich

Summer 2008

(U. Chicago Class of 2012; MD)

Biochemical characterization of the TRPM2 NUDIX domain and its interaction with nucleotides (MCO/SROH Leadership Alliance Intern)

Kevin C. Ni

2010-2012 (MD/PhD ’21, Indiana U)

Thesis title: Structural insights into asymmetric motor domains of the ABC transporter TAP (PRISE Fellow)

Robert Powers

2011-2014

(PhD student, Harvard Biophysics Program; Patent Agent, Cooley LLP)

Thesis title: Structural study of a novel partial Ca2+-free linker and a positively selected variation in Protocadherin-15: Implications for hearing and cell adhesion

(PRISE Fellow, Hershel Smith Fellow, Hoopes Prize)

First author, Structure 2017

Emily Lingeman

Summer 2012 (U. Wisconsin Madison ’14; PhD student at Berkeley)

Functional studies of NRAMP homologs

(MCO/SROH Leadership Alliance Intern)

Alexandra Rojek

2012-2013 (Harvard ’15; MD student at UCSF)

Functional studies of NRAMP homologs

Erik Zheng

2012-2015 (MD/PhD student, Tri-Institute program, NY)

Thesis title: The molecular basis of capsaicin sensitivity in the nociceptor TRPV1 (PRISE and Hershel Smith Fellow)

Linda Honaker

Summer 2013 (SDSU ’14; PhD student, Harvard MCO program)

Structural studies of TRPV channels

(MCO/SROH Leadership Alliance Intern)

Jenifer Brown

2013-2015 (PhD ’21 Stanford)

Thesis title: Engineered chimeric natural resistance associated macrophage proteins (NRAMPs) for antibody co-crystallization

(PRISE Fellow)

Peter O’Byrne

Summer 2014 (Trinity College, Dublin Ireland ’15; PhD student, Trinity College)

Structural studies of clustered protocadherins

Patrick Bruck

Summer 2014 (Creighton University ’16; Research Assistant, HMS ’17-’19; PhD student at UCSD )

Functional assays of yeast Ste6 transporter homologs (MCO/SROH Leadership Alliance Intern)

Hannah Zurier

2015-2017 (PhD student at Cornell University)

Thesis title: Structural and Biophysical Studies of Ligand Binding and Cytosolic Interactions in TRPA1 (PRISE Fellow)

Bennett Vogt

2015-2017 (Consultant, ClearView Life Sciences ’17-’19; UMASS Medical School)

Thesis title: Investigating the assembly of clustered protocadherins involved in dendrite self-avoidance (PRISE Fellow)

Co-author, eLife 2016

Benjamin Barnett

2015-2017 (Research Assistant, NYU)

Structure and function of Nramp transporters

Co-author, JBC 2020

José Velilla

Summer 2015 (University of Florida ’16; PhD student, Harvard Chemical Biology)

Assembly of TRPC channel intracellular domains (MCO/SROH Leadership Alliance Intern)

Brandon Lee

2015-2016 (Harvard ’19)

Structure and function of Nramp transporters

Valia Leifer

Spring 2016 (Harvard ’19; Research Assistant at HMS)

Membrane protein structure analyses

Stephanie Kabeche

Summer 2016 (University of Miami ’16; PhD Student at Stanford)

Structure of clustered protocadherins

(MCO/SROH Leadership Alliance Intern)

Casey Zhang

2017-2020

Structural analyses of LeuT-fold transporters (PRISE Fellow)

Co-author, eLife 2019

Nhu Dang

2017-present

Structural studies of C-type clustered protocadherins (PRISE and Hershel Smith Fellow)

Keri Ngo

Summer 2017 (Boston U ’18; Graduate Student, Stanford)

Structure of clustered protocadherins

MCO/SROH Leadership Alliance Intern

Brenda Chiang

2018-2019 (UCSF Medical School)

Thesis title: Promiscuity and Specificity of Clustered Protocadherin Binding Interfaces (PRISE Fellow)

Mit Patel

2018-2021

Thesis title: Uncovering the Structure and Function of ZmaM: A Peptidase-Transporter Fusion Protein (PRISE Fellow)

Agnele Sewa

Summer 2018 (Brandeis ’20; PhD Student at Stanford)

Structural determinants of metal binding in Nramp transition metal transporters

MCO/SROH Leadership Alliance Intern

Unice Yoo

2018-2020 (Research Scientist at Nference)

Thesis title: Determining metal selectivity imparted by variations in the metal-binding site of Nramp-family (PRISE Fellow)

Arianna Broad

Summer 2019 (Florida State University ’20)

Functional studies of insect gustatory receptors (MCO/SROH Leadership Alliance Intern)

Femke Ahlers

Summer 2019 (Cambridge University ’20)

Structural studies of Nramp transporters (Emmanuel College PRISE Fellow)

Serin Baek

2019-2021

Thesis title: Exploring the Structure and Substrate Specificity of Two Insect Gustatory Receptors (PRISE and Hershel Smith Fellow)

Jacob Licht

2020-2021

Thesis title: A Systematic Comparison of Conformational Movements of LeuT-fold Transporters (PRISE Fellow)

Tammie Tam

Summer 2021 (UC Davis)

Bioinformatics analyses of bacterial Nramp-like transporters

Emily Villalpando

Summer 2021 (UC Riverside)

Bioinformatics analyses of bacterial peptidases and transporters

Edward Lee

2020-2022

Thesis title: Determining the Metal Transport Features of the Eggerthella lenta Nramp-like Proteins

 

Masters Students

   

Valerie Daum

2018-2020

Role of the C-terminus in TRPA 1 structure and function

Research Assistants

Jason Touhey

2004-2006

(Hospitalist)

Structure of the TRPV2 ankyrin repeats

Co-author JBC 2006

Amanda McFedries

2008-2009

(Harvard PhD ’14; WarpDrive Bio Inc.)

Structure and function of the TAP transporter

Gavin MacKinnon

Extension School Volunteer 2008-2009

(MD Student, U. Michigan)

Cysteine-scanning mutagenesis of TRPV1

High school students

Serena Blacklow

2011-2013

(Harvard College ’17 MD/PhD Student, UCSF)

Lipid binding of TRPV ankyrin repeats

Julia Burnett

2015-2016 (Amherst College ’20)

TAP nucleotide binding domain dimerization

Research Interns

Nina Christ

Spring 2014 (Goethe University PhD ’14; Postdoc University of Mainz)

Structure and function of TRPV2 and TRPV4

Antonia Lott

2016-2017 (Eberhard Karls University)

Structural studies of bacterial Nramp homologs

       
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