The course aims to develop fundamental concepts of biochemistry as they apply to macromolecules, including protein and nucleic acid structure, thermodynamics and kinetics, ligand interactions and chemical equilibria. The course will also emphasize how these concepts are used in studies of the structure and function of biological molecules, including examples from metabolism. In the weekly section, students will undertake a discovery-based laboratory research project in which they will apply these concepts toward understanding the structure and function of the ATPase domain from the ABC transporter associated with antigen processing (TAP).
This course will introduce basic principles in general, organic and physical chemistry, including kinetics and thermodynamics, as well as macromolecular structure. Concepts will be illustrated with examples taken from the visual system.
MCB 355. Visualizing, Analyzing and Presenting Macromolecular Structures with PyMOL
PyMOL is one of the most popular software programs to display and explore high-resolution structures of macromolecules. It is readily used to create publication-quality figures, and movies and animations of structural information. In this course, you will learn the basics of PyMOL and be able to display, explore and present three-dimensional structures of macromolecules. With this basic training, you will be able to generate high-quality images and simple movies, and have the resources to learn more on your own to generate more complex displays