Andreane Cartier

Andreane Cartier

Research Fellow, Vascular Biology Program, Boston Children's Hospital
Research Fellow, Harvard Medical School
Andreane Cartier, Ph.D.
I did my PhD in the lab of Dr Jean-Luc Parent in Sherbrooke, Quebec. I characterized a newly identified interacting protein (WDR36) of the beta isoform of the thromboxane A2 receptor (TPβ), a GPCR that regulates platelets aggregation and vascular smooth muscle cells constriction.
 
My training with Dr Timothy Hla gives me the opportunity to apply to mouse models my knowledge of GPCR signaling, molecular biology and transcriptional gene regulation.
 
Project 1. Role of endothelial cell S1P1 and S1P2 receptors in tumor angiogenesis and tumor growth.
 
Project 2. Whole genome siRNA screen to identify new targets of the endocytic pathway of S1P1 induced by Fingolimod, a synthetic functional antagonist of S1P1 and FDA approved molecule, currently used as a treatment for multiple sclerosis.
 
Project 3. Role of S1P1 and S1P2 in vascular dysfunction caused by a chronic inflammatory environment in vitro and in vivo, and how the imbalance of these two receptors leads to endothelial dysfunction and vascular injury, key processes in cardiovascular diseases development.
 
Publications Highlights
Binda C, Génier S, Cartier A, Larrivée JF, Stankova J, Young JC and Parent JL. A G protein-coupled receptor and the intracellular synthase of its agonist functionally cooperate. J Cell Biol. 2014 Feb 3;204(3):377-93.
 
Lachance V, Cartier A, Génier S, Munger S, Germain P, Labrecque P and Parent JL. Regulation of b2-adrenergic receptor maturation and anterograde trafficking by an interaction with Rab geranylgeranyltransferase: modulation of Rab geranylgeranylation by the receptor. J Biol Chem. 2011 Nov 25;286(47):40802-13.
 
Cartier A., Parent A., Labrecque P, Laroche G and Parent JL. WDR36 acts as a scaffold protein tethering a G protein-coupled receptor, Gaq and a phospholipase Cb in a signaling complex. J Cell Sci. 2011 Oct 1;124(Pt 19):3292-304.
 
Phone: (617) 919-2404