2018
Burg N, Swendeman S, Worgall S, Hla T, Salmon JE. Sphingosine -1 Phosphate Receptor-1 signaling maintains endothelial cell barrier function and protects against immune complex-induced vascular injury. Arthritis Rheumatol. 2018 May 21.
Ghosh M, Thangada S, Dasgupta O, Khanna KM, Yamase HT, Kashgarian M, Hla T, Shapiro LH, Ferrer FA. Cell-intrinsic sphingosine kinase 2 promotes macrophage polarization and renal inflammation in response to unilateral ureteral obstruction. PLoS One. 2018 Mar 8.
2017
Yanagida K, Hla T. A dark side to omega-3 fatty acids. Nature. 2017 Dec 14.
Kono M, Conlon EG, Lux SY, Yanagida K, Hla T, Proia RL. Bioluminescence imaging of G protein-coupled receptor activation in living mice. Nat Commun. 2017 Oct 27.
Mendelson K, Pandey S, Hisano Y, Carellini F, Das BC, Hla T, Evans T. The ceramide synthase 2b gene mediates genomic sensing and regulation of sphingosine levels during zebrafish embryogenesis. Elife. 2017 Sep 28.
Singh RK, Haka AS, Brumfield A, Grosheva I, Bhardwaj P, Chin HF, Xiong Y, Hla T, Maxfield FR. Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism. J Lipid Res. 2017 Oct
Swendeman SL, Xiong Y, Cantalupo A, Yuan H, Burg N, Hisano Y, Cartier A, Liu CH, Engelbrecht E, Blaho V, Zhang Y, Yanagida K, Galvani S, Obinata H, Salmon JE, Sanchez T, Di Lorenzo A, Hla T. An engineered S1P chaperone attenuates hypertension and ischemic injury. Sci Signal. 2017 Aug 15.
Cantalupo A, Gargiulo A, Dautaj E, Liu C, Zhang Y, Hla T, Di Lorenzo A. S1PR1 (Sphingosine-1-Phosphate Receptor 1) Signaling Regulates Blood Flow and Pressure. Hypertension. 2017 Jun 12.
Galvani S, Hla T. Quality Versus Quantity: Making HDL Great Again. Arterioscler Thromb Vasc Biol. 2017 Jun;37(6):1018-1019.
Mendoza A, Fang V, Chen C, Serasinghe M, Verma A, Muller J, Chaluvadi VS, Dustin ML, Hla T, Elemento O, Chipuk JE, Schwab SR. Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells. Nature. 2017 Jun 1;546(7656):158-161. Epub 2017 May 24.
Yanagida K, Liu CH, Faraco G, Galvani S, Smith HK, Burg N, Anrather J, Sanchez T, Iadecola C, Hla T. Size-selective opening of the blood-brain barrier bytargeting endothelial sphingosine 1-phosphate receptor 1. Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4531-4536. Epub 2017 Apr 10.
Yanagida K, Hla T. Vascular and Immunobiology of the Circulatory Sphingosine 1-Phosphate Gradient. Annu Rev Physiol. Feb 10 2017;79:67-91.
2016
Xiong Y, Lee HJ, Mariko B, et al. Sphingosine kinases are not required for inflammatory responses in macrophages. J Biol Chem. May 20 2016;291(21):11465.
Gazit SL, Mariko B, Therond P, et al. Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. Circ Res. Sep 30 2016;119(8):e110-126.
Ding BS, Liu CH, Sun Y, et al. HDL activation of endothelial sphingosine-1-phosphate receptor-1 (S1P1) promotes regeneration and suppresses fibrosis in the liver. JCI Insight. Dec 22 2016;1(21):e87058.
Christensen PM, Liu CH, Swendeman SL, et al. Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1. Faseb j. Jun 2016;30(6):2351-2359.
2015
Wagschal A, Najafi-Shoushtari SH, Wang L, et al. Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis. Nat Med. Nov 2015;21(11):1290-1297.
Proia RL, Hla T. Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. J Clin Invest. Apr 2015;125(4):1379-1387.
Mendelson K, Lan Y, Hla T, Evans T. Maternal or zygotic sphingosine kinase is required to regulate zebrafish cardiogenesis. Dev Dyn. Aug 2015;244(8):948-954.
Li MH, Swenson R, Harel M, et al. Antitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma. J Pharmacol Exp Ther. Sep 2015;354(3):261-268.
Galvani S, Sanson M, Blaho VA, et al. HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation. Sci Signal. Aug 11 2015;8(389):ra79.
Etemadi N, Chopin M, Anderton H, et al. TRAF2 regulates TNF and NF-kappaB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1. Elife. Dec 23 2015;4. (Correction: TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1. Elife. Jun 27 2017)
Cantalupo A, Zhang Y, Kothiya M, et al. Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure. Nat Med. Sep 2015;21(9):1028-1037.
Blaho VA, Galvani S, Engelbrecht E, et al. HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation. Nature. Jul 16 2015;523(7560):342-346.
2014
Xiong Y, Yang P, Proia RL, Hla T. Erythrocyte-derived sphingosine 1-phosphate is essential for vascular development. J Clin Invest. Nov 2014;124(11):4823-4828.
Xiong Y, Hla T. S1P control of endothelial integrity. Curr Top Microbiol Immunol. 2014;378:85-105.
Thangada S, Shapiro LH, Silva C, Yamase H, Hla T, Ferrer FA. Treatment with the immunomodulator FTY720 (fingolimod) significantly reduces renal inflammation in murine unilateral ureteral obstruction. J Urol. May 2014;191(5 Suppl):1508-1516.
Obinata H, Gutkind S, Stitham J, et al. Individual variation of human S1P(1) coding sequence leads to heterogeneity in receptor function and drug interactions. J Lipid Res. Dec 2014;55(12):2665-2675.
Murakami K, Kohno M, Kadoya M, et al. Knock out of S1P3 receptor signaling attenuates inflammation and fibrosis in bleomycin-induced lung injury mice model. PLoS One. 2014;9(9):e106792.
Mendelson K, Evans T, Hla T. Sphingosine 1-phosphate signalling. Development. Jan 2014;141(1):5-9.
Lu YC, Chang SH, Hafner M, et al. ELAVL1 modulates transcriptome-wide miRNA binding in murine macrophages. Cell Rep. Dec 24 2014;9(6):2330-2343.
Li X, Lu YC, Dai K, Torregroza I, Hla T, Evans T. Elavl1a regulates zebrafish erythropoiesis via posttranscriptional control of gata1. Blood. Feb 27 2014;123(9):1384-1392.
Li MH, Harel M, Hla T, Ferrer F. Induction of chemokine (C-C motif) ligand 2 by sphingosine-1-phosphate signaling in neuroblastoma. J Pediatr Surg. Aug 2014;49(8):1286-1291.
Huang C, Gonzalez DG, Cote CM, et al. The BCL6 RD2 domain governs commitment of activated B cells to form germinal centers. Cell Rep. Sep 11 2014;8(5):1497-1508.
Hla T, Kolesnick R. C16:0-ceramide signals insulin resistance. Cell Metab. Nov 04 2014;20(5):703-705.
Henning J, Hla T, Meers J. Interdisciplinary communication of infectious disease research - translating complex epidemiological findings into understandable messages for village chicken farmers in Myanmar. Springerplus. 2014;3:726.
Giammanco A, Blanc V, Montenegro G, et al. Intestinal epithelial HuR modulates distinct pathways of proliferation and apoptosis and attenuates small intestinal and colonic tumor development. Cancer Res. Sep 15 2014;74(18):5322-5335.
Garris CS, Blaho VA, Hla T, Han MH. Sphingosine-1-phosphate receptor 1 signalling in T cells: trafficking and beyond. Immunology. Jul 2014;142(3):347-353.
Chang SH, Hla T. Post-transcriptional gene regulation by HuR and microRNAs in angiogenesis. Curr Opin Hematol. May 2014;21(3):235-240.
Chang SH, Elemento O, Zhang J, Zhuang ZW, Simons M, Hla T. ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis. Proc Natl Acad Sci U S A. Dec 23 2014;111(51):18309-18314.
Camm J, Hla T, Bakshi R, Brinkmann V. Cardiac and vascular effects of fingolimod: mechanistic basis and clinical implications. Am Heart J. Nov 2014;168(5):632-644.
Blaho VA, Hla T. An update on the biology of sphingosine 1-phosphate receptors. J Lipid Res. Aug 2014;55(8):1596-1608.
2013
Xiong Y, Lee HJ, Mariko B, et al. Sphingosine kinases are not required for inflammatory responses in macrophages. J Biol Chem. Nov 08 2013;288(45):32563-32573.
Montrose DC, Scherl EJ, Bosworth BP, et al. S1P(1) localizes to the colonic vasculature in ulcerative colitis and maintains blood vessel integrity. J Lipid Res. Mar 2013;54(3):843-851.
Mendelson K, Zygmunt T, Torres-Vazquez J, Evans T, Hla T. Sphingosine 1-phosphate receptor signaling regulates proper embryonic vascular patterning. J Biol Chem. Jan 25 2013;288(4):2143-2156.
Li MH, Hla T, Ferrer F. FTY720 inhibits tumor growth and enhances the tumor-suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathway. Pediatr Blood Cancer. Sep 2013;60(9):1418-1423.
Howe LR, Subbaramaiah K, Kent CV, et al. Genetic deletion of microsomal prostaglandin E synthase-1 suppresses mouse mammary tumor growth and angiogenesis. Prostaglandins Other Lipid Mediat. Oct 2013;106:99-105.
Henning J, Morton J, Pym R, Hla T, Sunn K, Meers J. Economic analysis of interventions to improve village chicken production in Myanmar. Prev Vet Med. Jul 01 2013;110(3-4):525-540.
Garris CS, Wu L, Acharya S, et al. Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation. Nat Immunol. Nov 2013;14(11):1166-1172.
Chang SH, Lu YC, Li X, et al. Antagonistic function of the RNA-binding protein HuR and miR-200b in post-transcriptional regulation of vascular endothelial growth factor-A expression and angiogenesis. J Biol Chem. Feb 15 2013;288(7):4908-4921.
2012
Torregroza I, Holtzinger A, Mendelson K, Liu TC, Hla T, Evans T. Regulation of a vascular plexus by gata4 is mediated in zebrafish through the chemokine sdf1a. PLoS One. 2012;7(10):e46844.
Takeshita H, Kitano M, Iwasaki T, et al. Sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling regulates receptor activator of NF-kappaB ligand (RANKL) expression in rheumatoid arthritis. Biochem Biophys Res Commun. Mar 09 2012;419(2):154-159.
Obinata H, Hla T. Sphingosine 1-phosphate in coagulation and inflammation. Semin Immunopathol. Jan 2012;34(1):73-91.
Obinata H, Hla T. Assessment of sphingosine-1-phosphate activity in biological samples by receptor internalization and adherens junction formation. Methods Mol Biol. 2012;874:69-76.
Obinata H, Hla T. Fine-tuning S1P therapeutics. Chem Biol. Sep 21 2012;19(9):1080-1082.
Moolenaar WH, Hla T. SnapShot: Bioactive lysophospholipids. Cell. Jan 20 2012;148(1-2):378-378.e372.
Jung B, Obinata H, Galvani S, et al. Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development. Dev Cell. Sep 11 2012;23(3):600-610.
Hla T, Galvani S, Rafii S, Nachman R. S1P and the birth of platelets. J Exp Med. Nov 19 2012;209(12):2137-2140.
Hla T, Dannenberg AJ. Sphingolipid signaling in metabolic disorders. Cell Metab. Oct 03 2012;16(4):420-434.
2011
Subbaramaiah K, Howe LR, Bhardwaj P, et al. Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer Prev Res (Phila). Mar 2011;4(3):329-346.
Skoura A, Michaud J, Im DS, et al. Sphingosine-1-phosphate receptor-2 function in myeloid cells regulates vascular inflammation and atherosclerosis. Arterioscler Thromb Vasc Biol. Jan 2011;31(1):81-85.
Oo ML, Chang SH, Thangada S, et al. Engagement of S1P(1)-degradative mechanisms leads to vascular leak in mice. J Clin Invest. Jun 2011;121(6):2290-2300.
Li MH, Hla T, Ferrer F. Sphingolipid modulation of angiogenic factor expression in neuroblastoma. Cancer Prev Res (Phila). Aug 2011;4(8):1325-1332.
Hla T, Brinkmann V. Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation. Neurology. Feb 22 2011;76(8 Suppl 3):S3-8.
Christoffersen C, Obinata H, Kumaraswamy SB, et al. Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M. Proc Natl Acad Sci U S A. Jun 07 2011;108(23):9613-9618.
Chang SH, Hla T. Gene regulation by RNA binding proteins and microRNAs in angiogenesis. Trends Mol Med. Nov 2011;17(11):650-658.
Blaho VA, Hla T. Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors. Chem Rev. Oct 12 2011;111(10):6299-6320.
2010
Thangada S, Khanna KM, Blaho VA, et al. Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics. J Exp Med. Jul 05 2010;207(7):1475-1483.
Michaud J, Im DS, Hla T. Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation. J Immunol. Feb 01 2010;184(3):1475-1483.
Hla T, Oo ML. Ramping up RANTES in the acute response to arterial injury. J Clin Invest. Jan 2010;120(1):90-92.
Habrukowich C, Han DK, Le A, et al. Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells. J Biol Chem. Aug 27 2010;285(35):26825-26831.
Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH. International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacol Rev. Dec 2010;62(4):579-587.
2009
ter Braak M, Danneberg K, Lichte K, et al. Galpha(q)-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors. Biochim Biophys Acta. May 2009;1791(5):357-370.
Skoura A, Hla T. Lysophospholipid receptors in vertebrate development, physiology, and pathology. J Lipid Res. Apr 2009;50 Suppl:S293-298.
Skoura A, Hla T. Regulation of vascular physiology and pathology by the S1P2 receptor subtype. Cardiovasc Res. May 01 2009;82(2):221-228.
Li MH, Sanchez T, Yamase H, et al. S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor. Cancer Lett. Apr 18 2009;276(2):171-179.
Li MH, Sanchez T, Milne GL, Morrow JD, Hla T, Ferrer F. S1P/S1P2 signaling induces cyclooxygenase-2 expression in Wilms tumor. J Urol. Mar 2009;181(3):1347-1352.
Hla T, Im DS. Cell biology. The ABCs of lipophile transport. Science. Feb 13 2009;323(5916):883-884.
Hla T. Plugging vascular leak by sphingosine kinase from bone marrow progenitor cells. Circ Res. Sep 25 2009;105(7):614-616.
Henning J, Morton J, Pym R, Hla T, Meers J. Evaluation of strategies to improve village chicken production: controlled field trials to assess effects of Newcastle disease vaccination and altered chick rearing in Myanmar [corrected]. Prev Vet Med. Jul 01 2009;90(1-2):17-30.
Ghosh M, Ai Y, Narko K, Wang Z, Peters JM, Hla T. PPARdelta is pro-tumorigenic in a mouse model of COX-2-induced mammary cancer. Prostaglandins Other Lipid Mediat. Apr 2009;88(3-4):97-100.
Ghosh M, Aguila HL, Michaud J, et al. Essential role of the RNA-binding protein HuR in progenitor cell survival in mice. J Clin Invest. Dec 2009;119(12):3530-3543.
2008
Wang Z, Liu B, Wang P, et al. Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice. J Clin Invest. Jan 2008;118(1):195-204.
Venkataraman K, Lee YM, Michaud J, et al. Vascular endothelium as a contributor of plasma sphingosine 1-phosphate. Circ Res. Mar 28 2008;102(6):669-676.
Subbaramaiah K, Hudis C, Chang SH, Hla T, Dannenberg AJ. EP2 and EP4 receptors regulate aromatase expression in human adipocytes and breast cancer cells. Evidence of a BRCA1 and p300 exchange. J Biol Chem. Feb 08 2008;283(6):3433-3444.
Sekiguchi M, Iwasaki T, Kitano M, et al. Role of sphingosine 1-phosphate in the pathogenesis of Sjogren's syndrome. J Immunol. Feb 01 2008;180(3):1921-1928.
Li MH, Sanchez T, Pappalardo A, Lynch KR, Hla T, Ferrer F. Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2. Mol Cancer Res. Oct 2008;6(10):1649-1656.
Hla T, Venkataraman K, Michaud J. The vascular S1P gradient-cellular sources and biological significance. Biochim Biophys Acta. Sep 2008;1781(9):477-482.
Henning J, Morton J, Hla T, Meers J. Mortality rates adjusted for unobserved deaths and associations with Newcastle disease virus serology among unvaccinated village chickens in Myanmar. Prev Vet Med. Jul 15 2008;85(3-4):241-252.
Estrada R, Zeng Q, Lu H, et al. Up-regulating sphingosine 1-phosphate receptor-2 signaling impairs chemotactic, wound-healing, and morphogenetic responses in senescent endothelial cells. J Biol Chem. Oct 31 2008;283(44):30363-30375.
2007
Soldi R, Mandinova A, Venkataraman K, et al. Sphingosine kinase 1 is a critical component of the copper-dependent FGF1 export pathway. Exp Cell Res. Sep 10 2007;313(15):3308-3318.
Skoura A, Sanchez T, Claffey K, Mandala SM, Proia RL, Hla T. Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina. J Clin Invest. Sep 2007;117(9):2506-2516.
Sanchez T, Skoura A, Wu MT, Casserly B, Harrington EO, Hla T. Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN. Arterioscler Thromb Vasc Biol. Jun 2007;27(6):1312-1318.
Oo ML, Thangada S, Wu MT, et al. Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. J Biol Chem. Mar 23 2007;282(12):9082-9089.
Lee YM, Venkataraman K, Hwang SI, Han DK, Hla T. A novel method to quantify sphingosine 1-phosphate by immobilized metal affinity chromatography (IMAC). Prostaglandins Other Lipid Mediat. Nov 2007;84(3-4):154-162.
Kono M, Belyantseva IA, Skoura A, et al. Deafness and stria vascularis defects in S1P2 receptor-null mice. J Biol Chem. Apr 06 2007;282(14):10690-10696.
Hla T, Feinmark SJ. A festschrift for J. Martyn Bailey, a biochemist extraordinaire. Prostaglandins Other Lipid Mediat. Feb 2007;83(1-2):154-157.
Gonzalez-Cabrera PJ, Hla T, Rosen H. Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics. J Biol Chem. Mar 09 2007;282(10):7254-7264.
Ghosh M, Wang H, Ai Y, et al. COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARdelta activation. J Exp Med. Sep 03 2007;204(9):2053-2061.
2006
Venkataraman K, Thangada S, Michaud J, et al. Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient. Biochem J. Aug 01 2006;397(3):461-471.
Thompson B, Ancellin N, Fernandez SM, Hla T, Sha'afi RI. Protein kinase Calpha and sphingosine 1-phosphate-dependent signaling in endothelial cell. Prostaglandins Other Lipid Mediat. Jul 2006;80(1-2):15-27.
Subbaramaiah K, Howe LR, Port ER, et al. HER-2/neu status is a determinant of mammary aromatase activity in vivo: evidence for a cyclooxygenase-2-dependent mechanism. Cancer Res. May 15 2006;66(10):5504-5511.
Michaud J, Kohno M, Proia RL, Hla T. Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice. FEBS Lett. Aug 21 2006;580(19):4607-4612.
Lee JF, Zeng Q, Ozaki H, et al. Dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial chemotaxis and barrier integrity. J Biol Chem. Sep 29 2006;281(39):29190-29200.
Lee JF, Ozaki H, Zhan X, Wang E, Hla T, Lee MJ. Sphingosine-1-phosphate signaling regulates lamellipodia localization of cortactin complexes in endothelial cells. Histochem Cell Biol. Sep 2006;126(3):297-304.
LaMontagne K, Littlewood-Evans A, Schnell C, et al. Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization. Cancer Res. Jan 01 2006;66(1):221-231.
Kohno M, Momoi M, Oo ML, et al. Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Mol Cell Biol. Oct 2006;26(19):7211-7223.
Kitano M, Hla T, Sekiguchi M, et al. Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression. Arthritis Rheum. Mar 2006;54(3):742-753.
Henning J, Khin A, Hla T, Meers J. Husbandry and trade of indigenous chickens in Myanmar--results of a participatory rural appraisal in the Yangon and the Mandalay divisions. Trop Anim Health Prod. Oct-Nov 2006;38(7-8):611-618.
2005
Sanchez T, Thangada S, Wu MT, et al. PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc Natl Acad Sci U S A. Mar 22 2005;102(12):4312-4317.
Rapaka RS, Hla T, Dey SK. The dawn of lipidomics. Prostaglandins Other Lipid Mediat. Sep 2005;77(1-4):1-3.
Narko K, Zweifel B, Trifan O, Ristimaki A, Lane TF, Hla T. COX-2 inhibitors and genetic background reduce mammary tumorigenesis in cyclooxygenase-2 transgenic mice. Prostaglandins Other Lipid Mediat. May 2005;76(1-4):86-94.
Li Z, Paik JH, Wang Z, Hla T, Wu D. Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells. Prostaglandins Other Lipid Mediat. May 2005;76(1-4):95-104.
Li Z, Dong X, Wang Z, et al. Regulation of PTEN by Rho small GTPases. Nat Cell Biol. Apr 2005;7(4):399-404.
Lepley D, Paik JH, Hla T, Ferrer F. The G protein-coupled receptor S1P2 regulates Rho/Rho kinase pathway to inhibit tumor cell migration. Cancer Res. May 01 2005;65(9):3788-3795.
Jo E, Sanna MG, Gonzalez-Cabrera PJ, et al. S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate. Chem Biol. Jun 2005;12(6):703-715.
Howe LR, Chang SH, Tolle KC, et al. HER2/neu-induced mammary tumorigenesis and angiogenesis are reduced in cyclooxygenase-2 knockout mice. Cancer Res. Nov 01 2005;65(21):10113-10119.
Hla T. Genomic insights into mediator lipidomics. Prostaglandins Other Lipid Mediat. Sep 2005;77(1-4):197-209.
Hla T. Immunology. Dietary factors and immunological consequences. Science. Sep 09 2005;309(5741):1682-1683.
Heinonen M, Bono P, Narko K, et al. Cytoplasmic HuR expression is a prognostic factor in invasive ductal breast carcinoma. Cancer Res. Mar 15 2005;65(6):2157-2161.
Chang SH, Liu CH, Wu MT, Hla T. Regulation of vascular endothelial cell growth factor expression in mouse mammary tumor cells by the EP2 subtype of the prostaglandin E2 receptor. Prostaglandins Other Lipid Mediat. May 2005;76(1-4):48-58.
Chang SH, Ai Y, Breyer RM, Lane TF, Hla T. The prostaglandin E2 receptor EP2 is required for cyclooxygenase 2-mediated mammary hyperplasia. Cancer Res. Jun 01 2005;65(11):4496-4499.
Chae SS, Hla T. Inhibition of gene expression in vivo using multiplex siRNA. Methods Mol Biol. 2005;309:197-203.
2004
Simmons DL, Botting RM, Hla T. Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. Pharmacol Rev. Sep 2004;56(3):387-437.
Sanchez T, Hla T. Structural and functional characteristics of S1P receptors. J Cell Biochem. Aug 01 2004;92(5):913-922.
Saba JD, Hla T. Point-counterpoint of sphingosine 1-phosphate metabolism. Circ Res. Apr 02 2004;94(6):724-734.
Paik JH, Skoura A, Chae SS, et al. Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization. Genes Dev. Oct 01 2004;18(19):2392-2403.
Knostman KA, Cho JY, Ryu KY, et al. Signaling through 3',5'-cyclic adenosine monophosphate and phosphoinositide-3 kinase induces sodium/iodide symporter expression in breast cancer. J Clin Endocrinol Metab. Oct 2004;89(10):5196-5203.
Jang BC, Kim DH, Park JW, et al. Induction of cyclooxygenase-2 in macrophages by catalase: role of NF-kappaB and PI3K signaling pathways. Biochem Biophys Res Commun. Apr 02 2004;316(2):398-406.
Hla T. Prostaglandins & other lipid mediators: a new phase, a new team. Prostaglandins Other Lipid Mediat. Jan 2004;73(1-2):1-2.
Hla T. Physiological and pathological actions of sphingosine 1-phosphate. Semin Cell Dev Biol. Oct 2004;15(5):513-520.
Chang SH, Liu CH, Conway R, et al. Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression. Proc Natl Acad Sci U S A. Jan 13 2004;101(2):591-596.
Chae SS, Proia RL, Hla T. Constitutive expression of the S1P1 receptor in adult tissues. Prostaglandins Other Lipid Mediat. Jan 2004;73(1-2):141-150.
Chae SS, Paik JH, Furneaux H, Hla T. Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference. J Clin Invest. Oct 2004;114(8):1082-1089.
Chae SS, Paik JH, Allende ML, Proia RL, Hla T. Regulation of limb development by the sphingosine 1-phosphate receptor S1p1/EDG-1 occurs via the hypoxia/VEGF axis. Dev Biol. Apr 15 2004;268(2):441-447.
Brinkmann V, Cyster JG, Hla T. FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. Am J Transplant. Jul 2004;4(7):1019-1025.
2003
Trifan OC, Hla T. Cyclooxygenase-2 modulates cellular growth and promotes tumorigenesis. J Cell Mol Med. Jul-Sep 2003;7(3):207-222.
Sengupta S, Jang BC, Wu MT, Paik JH, Furneaux H, Hla T. The RNA-binding protein HuR regulates the expression of cyclooxygenase-2. J Biol Chem. Jul 04 2003;278(27):25227-25233.
Sanchez T, Estrada-Hernandez T, Paik JH, et al. Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability. J Biol Chem. Nov 21 2003;278(47):47281-47290.
Ozaki H, Hla T, Lee MJ. Sphingosine-1-phosphate signaling in endothelial activation. J Atheroscler Thromb. 2003;10(3):125-131.
Kluk MJ, Colmont C, Wu MT, Hla T. Platelet-derived growth factor (PDGF)-induced chemotaxis does not require the G protein-coupled receptor S1P1 in murine embryonic fibroblasts and vascular smooth muscle cells. FEBS Lett. Jan 02 2003;533(1-3):25-28.
Jang BC, Munoz-Najar U, Paik JH, Claffey K, Yoshida M, Hla T. Leptomycin B, an inhibitor of the nuclear export receptor CRM1, inhibits COX-2 expression. J Biol Chem. Jan 31 2003;278(5):2773-2776.
Inaba T, Sano H, Kawahito Y, et al. Induction of cyclooxygenase-2 in monocyte/macrophage by mucins secreted from colon cancer cells. Proc Natl Acad Sci U S A. Mar 04 2003;100(5):2736-2741.
Hla T. Signaling and biological actions of sphingosine 1-phosphate. Pharmacol Res. May 2003;47(5):401-407.
Erkinheimo TL, Lassus H, Sivula A, et al. Cytoplasmic HuR expression correlates with poor outcome and with cyclooxygenase 2 expression in serous ovarian carcinoma. Cancer Res. Nov 15 2003;63(22):7591-7594.
Donohue PJ, Richards CM, Brown SA, et al. TWEAK is an endothelial cell growth and chemotactic factor that also potentiates FGF-2 and VEGF-A mitogenic activity. Arterioscler Thromb Vasc Biol. Apr 01 2003;23(4):594-600.
2002
Kluk MJ, Hla T. Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. Biochim Biophys Acta. May 23 2002;1582(1-3):72-80.
Chun J, Goetzl EJ, Hla T, et al. International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacol Rev. Jun 2002;54(2):265-269.
Bishop-Bailey D, Hla T, Warner TD. Intimal smooth muscle cells as a target for peroxisome proliferator-activated receptor-gamma ligand therapy. Circ Res. Aug 09 2002;91(3):210-217.
Bishop-Bailey D, Calatayud S, Warner TD, Hla T, Mitchell JA. Prostaglandins and the regulation of tumor growth. J Environ Pathol Toxicol Oncol. 2002;21(2):93-101.
Ancellin N, Colmont C, Su J, et al. Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation. J Biol Chem. Feb 22 2002;277(8):6667-6675.
2001
Tsubouchi Y, Kawahito Y, Kohno M, Inoue K, Hla T, Sano H. Feedback control of the arachidonate cascade in rheumatoid synoviocytes by 15-deoxy-Delta(12,14)-prostaglandin J2. Biochem Biophys Res Commun. May 18 2001;283(4):750-755.
Paik JH, Chae S, Lee MJ, Thangada S, Hla T. Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3- and beta1-containing integrins. J Biol Chem. Apr 13 2001;276(15):11830-11837.
Morales-Ruiz M, Lee MJ, Zollner S, et al. Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells. J Biol Chem. Jun 01 2001;276(22):19672-19677.
Liu CH, Chang SH, Narko K, et al. Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice. J Biol Chem. May 25 2001;276(21):18563-18569.
Lee MJ, Thangada S, Paik JH, et al. Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. Mol Cell. Sep 2001;8(3):693-704.
Kluk MJ, Hla T. Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration. Circ Res. Sep 14 2001;89(6):496-502.
Inoue K, Kawahito Y, Tsubouchi Y, et al. Expression of peroxisome proliferator-activated receptor (PPAR)-gamma in human lung cancer. Anticancer Res. Jul-Aug 2001;21(4a):2471-2476.
Hla T, Lee MJ, Ancellin N, Paik JH, Kluk MJ. Lysophospholipids--receptor revelations. Science. Nov 30 2001;294(5548):1875-1878.
Hla T. Sphingosine 1-phosphate receptors. Prostaglandins Other Lipid Mediat. Apr 2001;64(1-4):135-142.
Goetzl EJ, Tigyi GJ, Hla T. First international conference on lysophospholipids and related bioactive lipids in biology and disease sponsored by the Federation of American Societies of Experimental Biology. ScientificWorldJournal. Jul 17 2001;1:269-270.
Casibang M, Purdom S, Jakowlew S, et al. Prostaglandin E2 and vasoactive intestinal peptide increase vascular endothelial cell growth factor mRNAs in lung cancer cells. Lung Cancer. Feb-Mar 2001;31(2-3):203-212.
2000
Yoshimura R, Sano H, Masuda C, et al. Expression of cyclooxygenase-2 in prostate carcinoma. Cancer. Aug 01 2000;89(3):589-596.
Yamada R, Sano H, Hla T, et al. Selective inhibition of cyclooxygenase-2 with antisense oligodeoxynucleotide restricts induction of rat adjuvant-induced arthritis. Biochem Biophys Res Commun. Mar 16 2000;269(2):415-421.
Tsubouchi Y, Sano H, Kawahito Y, et al. Inhibition of human lung cancer cell growth by the peroxisome proliferator-activated receptor-gamma agonists through induction of apoptosis. Biochem Biophys Res Commun. Apr 13 2000;270(2):400-405.
Liu Y, Wada R, Yamashita T, et al. Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J Clin Invest. Oct 2000;106(8):951-961.
Kawahito Y, Kondo M, Tsubouchi Y, et al. 15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats. J Clin Invest. Jul 2000;106(2):189-197.
Jang BC, Sanchez T, Schaefers HJ, et al. Serum withdrawal-induced post-transcriptional stabilization of cyclooxygenase-2 mRNA in MDA-MB-231 mammary carcinoma cells requires the activity of the p38 stress-activated protein kinase. J Biol Chem. Dec 15 2000;275(50):39507-39515.
Im DS, Heise CE, Ancellin N, et al. Characterization of a novel sphingosine 1-phosphate receptor, Edg-8. J Biol Chem. May 12 2000;275(19):14281-14286.
Hla T, Lee MJ, Ancellin N, et al. Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors. Ann N Y Acad Sci. Apr 2000;905:16-24.
Clark RB, Bishop-Bailey D, Estrada-Hernandez T, Hla T, Puddington L, Padula SJ. The nuclear receptor PPAR gamma and immunoregulation: PPAR gamma mediates inhibition of helper T cell responses. J Immunol. Feb 01 2000;164(3):1364-1371.
Bishop-Bailey D, Hla T, Warner TD. Bisphenol A diglycidyl ether (BADGE) is a PPARgamma agonist in an ECV304 cell line. Br J Pharmacol. Oct 2000;131(4):651-654.
Ancellin N, Hla T. Switching intracellular signaling pathways to study sphingosine 1-phosphate receptors. Ann N Y Acad Sci. Apr 2000;905:260-262.
1999
Yamada R, Sano H, Hla T, et al. Auranofin inhibits interleukin-1beta-induced transcript of cyclooxygenase-2 on cultured human synoviocytes. Eur J Pharmacol. Nov 26 1999;385(1):71-79.
Windh RT, Lee MJ, Hla T, An S, Barr AJ, Manning DR. Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins. J Biol Chem. Sep 24 1999;274(39):27351-27358.
Trifan OC, Smith RM, Thompson BD, Hla T. Overexpression of cyclooxygenase-2 induces cell cycle arrest. Evidence for a prostaglandin-independent mechanism. J Biol Chem. Nov 26 1999;274(48):34141-34147.
Liu CH, Thangada S, Lee MJ, Van Brocklyn JR, Spiegel S, Hla T. Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1. Mol Biol Cell. Apr 1999;10(4):1179-1190.
Lee MJ, Thangada S, Claffey KP, et al. Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. Cell. Oct 29 1999;99(3):301-312.
Hla T, Lee MJ, Ancellin N, et al. Sphingosine-1-phosphate: extracellular mediator or intracellular second messenger? Biochem Pharmacol. Jul 15 1999;58(2):201-207.
Hla T, Bishop-Bailey D, Liu CH, Schaefers HJ, Trifan OC. Cyclooxygenase-1 and -2 isoenzymes. Int J Biochem Cell Biol. May 1999;31(5):551-557.
Bishop-Bailey D, Hla T, Mitchell JA. Cyclo-oxygenase-2 in vascular smooth muscle. Int J Mol Med. Jan 1999;3(1):41-48.
Bishop-Bailey D, Hla T. Endothelial cell apoptosis induced by the peroxisome proliferator-activated receptor (PPAR) ligand 15-deoxy-Delta12, 14-prostaglandin J2. J Biol Chem. Jun 11 1999;274(24):17042-17048.
Ancellin N, Hla T. Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. J Biol Chem. Jul 02 1999;274(27):18997-19002.
1998
Van Brocklyn JR, Lee MJ, Menzeleev R, et al. Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival. J Cell Biol. Jul 13 1998;142(1):229-240.
Lee MJ, Van Brocklyn JR, Thangada S, et al. Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. Science. Mar 06 1998;279(5356):1552-1555.
Lee MJ, Thangada S, Liu CH, Thompson BD, Hla T. Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist. J Biol Chem. Aug 21 1998;273(34):22105-22112.
Hida T, Leyton J, Makheja AN, et al. Non-small cell lung cancer cycloxygenase activity and proliferation are inhibited by non-steroidal antiinflammatory drugs. Anticancer Res. Mar-Apr 1998;18(2a):775-782.
Gou Q, Liu CH, Ben-Av P, Hla T. Dissociation of basal turnover and cytokine-induced transcript stabilization of the human cyclooxygenase-2 mRNA by mutagenesis of the 3'-untranslated region. Biochem Biophys Res Commun. Jan 26 1998;242(3):508-512.
1997
Narko K, Ristimaki A, MacPhee M, Smith E, Haudenschild CC, Hla T. Tumorigenic transformation of immortalized ECV endothelial cells by cyclooxygenase-1 overexpression. J Biol Chem. Aug 22 1997;272(34):21455-21460.
Liu CH, Hla T. The mouse gene for the inducible G-protein-coupled receptor edg-1. Genomics. Jul 01 1997;43(1):15-24.
Hla T, Zimrin AB, Evans M, Ballas K, Maciag T. The immediate-early gene product MAD-3/EDG-3/IkappaB alpha is an endogenous modulator of fibroblast growth factor-1 (FGF-1) dependent human endothelial cell growth. FEBS Lett. Sep 08 1997;414(2):419-424.
Crofford LJ, Tan B, McCarthy CJ, Hla T. Involvement of nuclear factor kappa B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid synoviocytes. Arthritis Rheum. Feb 1997;40(2):226-236.
1996
Ristimaki A, Narko K, Hla T. Down-regulation of cytokine-induced cyclo-oxygenase-2 transcript isoforms by dexamethasone: evidence for post-transcriptional regulation. Biochem J. Aug 15 1996;318 ( Pt 1):325-331.
Lee MJ, Evans M, Hla T. The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway. J Biol Chem. May 10 1996;271(19):11272-11279.
Hla T. Molecular characterization of the 5.2 KB isoform of the human cyclooxygenase-1 transcript. Prostaglandins. Jan 1996;51(1):81-85.
1995
Sano H, Kawahito Y, Wilder RL, et al. Expression of cyclooxygenase-1 and -2 in human colorectal cancer. Cancer Res. Sep 01 1995;55(17):3785-3789.
Hla T, Jackson AQ, Appleby SB, Maciag T. Characterization of edg-2, a human homologue of the Xenopus maternal transcript G10 from endothelial cells. Biochim Biophys Acta. Jan 25 1995;1260(2):227-229.
Ben-Av P, Crofford LJ, Wilder RL, Hla T. Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin-1: a potential mechanism for inflammatory angiogenesis. FEBS Lett. Sep 18 1995;372(1):83-87.
1994
Ristimaki A, Garfinkel S, Wessendorf J, Maciag T, Hla T. Induction of cyclooxygenase-2 by interleukin-1 alpha. Evidence for post-transcriptional regulation. J Biol Chem. Apr 22 1994;269(16):11769-11775.
Laneuville O, Breuer DK, Dewitt DL, Hla T, Funk CD, Smith WL. Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. Nov 1994;271(2):927-934.
Crofford LJ, Wilder RL, Ristimaki AP, et al. Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids. J Clin Invest. Mar 1994;93(3):1095-1101.
Appleby SB, Ristimaki A, Neilson K, Narko K, Hla T. Structure of the human cyclo-oxygenase-2 gene. Biochem J. Sep 15 1994;302 ( Pt 3):723-727.
1993
Sano H, Engleka K, Mathern P, et al. Coexpression of phosphotyrosine-containing proteins, platelet-derived growth factor-B, and fibroblast growth factor-1 in situ in synovial tissues of patients with rheumatoid arthritis and Lewis rats with adjuvant or streptococcal cell wall arthritis. J Clin Invest. Feb 1993;91(2):553-565.
Hla T, Ristimaki A, Appleby S, Barriocanal JG. Cyclooxygenase gene expression in inflammation and angiogenesis. Ann N Y Acad Sci. Nov 30 1993;696:197-204.
1992
Sano H, Hla T, Maier JA, et al. In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis. J Clin Invest. Jan 1992;89(1):97-108.
Hla T, Neilson K. Human cyclooxygenase-2 cDNA. Proc Natl Acad Sci U S A. Aug 15 1992;89(16):7384-7388.
1991
Siegall CB, Epstein S, Speir E, et al. Cytotoxic activity of chimeric proteins composed of acidic fibroblast growth factor and Pseudomonas exotoxin on a variety of cell types. Faseb j. Oct 1991;5(13):2843-2849.
Remmers EF, Sano H, Lafyatis R, et al. Production of platelet derived growth factor B chain (PDGF-B/c-sis) mRNA and immunoreactive PDGF B-like polypeptide by rheumatoid synovium: coexpression with heparin binding acidic fibroblast growth factor-1. J Rheumatol. Jan 1991;18(1):7-13.
Hla T, Maciag T. Cyclooxygenase gene expression is down-regulated by heparin-binding (acidic fibroblast) growth factor-1 in human endothelial cells. J Biol Chem. Dec 15 1991;266(35):24059-24063.
1990
Smith WL, DeWitt DL, Kraemer SA, et al. Structure-function relationships in sheep, mouse, and human prostaglandin endoperoxide G/H synthases. Adv Prostaglandin Thromboxane Leukot Res. 1990;20:14-21.
Maier JA, Hla T, Maciag T. Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells. J Biol Chem. Jul 05 1990;265(19):10805-10808.
Imamura T, Engleka K, Zhan X, et al. Recovery of mitogenic activity of a growth factor mutant with a nuclear translocation sequence. Science. Sep 28 1990;249(4976):1567-1570.
Hla T, Maciag T. Isolation of immediate-early differentiation mRNAs by enzymatic amplification of subtracted cDNA from human endothelial cells. Biochem Biophys Res Commun. Mar 16 1990;167(2):637-643.
Hla T, Maciag T. An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors. J Biol Chem. Jun 05 1990;265(16):9308-9313.
1989
Goldgaber D, Harris HW, Hla T, et al. Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. Proc Natl Acad Sci U S A. Oct 1989;86(19):7606-7610.
1986
Hla T, Farrell M, Kumar A, Bailey JM. Isolation of the cDNA for human prostaglandin H synthase. Prostaglandins. Dec 1986;32(6):829-845.
1985
Bailey JM, Muza B, Hla T, Salata K. Restoration of prostacyclin synthase in vascular smooth muscle cells after aspirin treatment: regulation by epidermal growth factor. J Lipid Res. Jan 1985;26(1):54-61.
Bailey JM, Muza B, Hla T, Pash J. Role of epidermal growth factor in cyclooxygenase synthesis. Adv Prostaglandin Thromboxane Leukot Res. 1985;15:141-142.
1979
Hagan KJ, Smith SE, Gyi KM, et al. The reliability of self-administration of dapsone by leprosy patients in Burma. Lepr Rev. Sep 1979;50(3):201-211.