Publications

2017
 
Cantalupo A, Gargiulo A, Dautaj E, Liu C, Zhang Y, Hla T, Di Lorenzo A. S1PR1 (Sphingosine-1-Phosphate Receptor 1) Signaling Regulates Blood Flow and Pressure. Hypertension. 2017 Jun 12.
 
Galvani S, Hla T. Quality Versus Quantity: Making HDL Great Again. Arterioscler Thromb Vasc Biol. 2017 Jun;37(6):1018-1019.
 
Mendoza A, Fang V, Chen C, Serasinghe M, Verma A, Muller J, Chaluvadi VS, Dustin ML, Hla T, Elemento O, Chipuk JE, Schwab SR. Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells. Nature. 2017 Jun 1;546(7656):158-161. Epub 2017 May 24.
 
Yanagida K, Liu CH, Faraco G, Galvani S, Smith HK, Burg N, Anrather J, Sanchez T, Iadecola C, Hla T. Size-selective opening of the blood-brain barrier bytargeting endothelial sphingosine 1-phosphate receptor 1. Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4531-4536. Epub 2017 Apr 10.
 
Yanagida K, Hla T. Vascular and Immunobiology of the Circulatory Sphingosine 1-Phosphate Gradient. Annu Rev Physiol. Feb 10 2017;79:67-91.
 
2016
 
Xiong Y, Lee HJ, Mariko B, et al. Sphingosine kinases are not required for inflammatory responses in macrophages. J Biol Chem. May 20 2016;291(21):11465.
 
 
 
 
2015
 
Wagschal A, Najafi-Shoushtari SH, Wang L, et al. Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis. Nat Med. Nov 2015;21(11):1290-1297.
 
Proia RL, Hla T. Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. J Clin Invest. Apr 2015;125(4):1379-1387.
Mendelson K, Lan Y, Hla T, Evans T. Maternal or zygotic sphingosine kinase is required to regulate zebrafish cardiogenesis. Dev Dyn. Aug 2015;244(8):948-954.
 
Li MH, Swenson R, Harel M, et al. Antitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma. J Pharmacol Exp Ther. Sep 2015;354(3):261-268.
 
 
 
Cantalupo A, Zhang Y, Kothiya M, et al. Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure. Nat Med. Sep 2015;21(9):1028-1037.
 
Blaho VA, Galvani S, Engelbrecht E, et al. HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation. Nature. Jul 16 2015;523(7560):342-346.
 
2014
 
Xiong Y, Yang P, Proia RL, Hla T. Erythrocyte-derived sphingosine 1-phosphate is essential for vascular development. J Clin Invest. Nov 2014;124(11):4823-4828.
 
Xiong Y, Hla T. S1P control of endothelial integrity. Curr Top Microbiol Immunol. 2014;378:85-105.
 
Thangada S, Shapiro LH, Silva C, Yamase H, Hla T, Ferrer FA. Treatment with the immunomodulator FTY720 (fingolimod) significantly reduces renal inflammation in murine unilateral ureteral obstruction. J Urol. May 2014;191(5 Suppl):1508-1516.
 
Obinata H, Gutkind S, Stitham J, et al. Individual variation of human S1P(1) coding sequence leads to heterogeneity in receptor function and drug interactions. J Lipid Res. Dec 2014;55(12):2665-2675.
 
 
Mendelson K, Evans T, Hla T. Sphingosine 1-phosphate signalling. Development. Jan 2014;141(1):5-9.
 
Lu YC, Chang SH, Hafner M, et al. ELAVL1 modulates transcriptome-wide miRNA binding in murine macrophages. Cell Rep. Dec 24 2014;9(6):2330-2343.
 
Li X, Lu YC, Dai K, Torregroza I, Hla T, Evans T. Elavl1a regulates zebrafish erythropoiesis via posttranscriptional control of gata1. Blood. Feb 27 2014;123(9):1384-1392.
 
Li MH, Harel M, Hla T, Ferrer F. Induction of chemokine (C-C motif) ligand 2 by sphingosine-1-phosphate signaling in neuroblastoma. J Pediatr Surg. Aug 2014;49(8):1286-1291.
 
Huang C, Gonzalez DG, Cote CM, et al. The BCL6 RD2 domain governs commitment of activated B cells to form germinal centers. Cell Rep. Sep 11 2014;8(5):1497-1508.
 
Hla T, Kolesnick R. C16:0-ceramide signals insulin resistance. Cell Metab. Nov 04 2014;20(5):703-705.
 
 
 
Garris CS, Blaho VA, Hla T, Han MH. Sphingosine-1-phosphate receptor 1 signalling in T cells: trafficking and beyond. Immunology. Jul 2014;142(3):347-353.
Chang SH, Hla T. Post-transcriptional gene regulation by HuR and microRNAs in angiogenesis. Curr Opin Hematol. May 2014;21(3):235-240.
 
Chang SH, Elemento O, Zhang J, Zhuang ZW, Simons M, Hla T. ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis. Proc Natl Acad Sci U S A. Dec 23 2014;111(51):18309-18314.
 
Camm J, Hla T, Bakshi R, Brinkmann V. Cardiac and vascular effects of fingolimod: mechanistic basis and clinical implications. Am Heart J. Nov 2014;168(5):632-644.
 
Blaho VA, Hla T. An update on the biology of sphingosine 1-phosphate receptors. J Lipid Res. Aug 2014;55(8):1596-1608.
 
2013
 
Xiong Y, Lee HJ, Mariko B, et al. Sphingosine kinases are not required for inflammatory responses in macrophages. J Biol Chem. Nov 08 2013;288(45):32563-32573.
 
Montrose DC, Scherl EJ, Bosworth BP, et al. S1P(1) localizes to the colonic vasculature in ulcerative colitis and maintains blood vessel integrity. J Lipid Res. Mar 2013;54(3):843-851.
 
Mendelson K, Zygmunt T, Torres-Vazquez J, Evans T, Hla T. Sphingosine 1-phosphate receptor signaling regulates proper embryonic vascular patterning. J Biol Chem. Jan 25 2013;288(4):2143-2156.
 
 
Howe LR, Subbaramaiah K, Kent CV, et al. Genetic deletion of microsomal prostaglandin E synthase-1 suppresses mouse mammary tumor growth and angiogenesis. Prostaglandins Other Lipid Mediat. Oct 2013;106:99-105.
 
Henning J, Morton J, Pym R, Hla T, Sunn K, Meers J. Economic analysis of interventions to improve village chicken production in Myanmar. Prev Vet Med. Jul 01 2013;110(3-4):525-540.
 
 
 
2012
 
Torregroza I, Holtzinger A, Mendelson K, Liu TC, Hla T, Evans T. Regulation of a vascular plexus by gata4 is mediated in zebrafish through the chemokine sdf1a. PLoS One. 2012;7(10):e46844.
 
Takeshita H, Kitano M, Iwasaki T, et al. Sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling regulates receptor activator of NF-kappaB ligand (RANKL) expression in rheumatoid arthritis. Biochem Biophys Res Commun. Mar 09 2012;419(2):154-159.
 
Obinata H, Hla T. Sphingosine 1-phosphate in coagulation and inflammation. Semin Immunopathol. Jan 2012;34(1):73-91.
 
 
Obinata H, Hla T. Fine-tuning S1P therapeutics. Chem Biol. Sep 21 2012;19(9):1080-1082.
 
Moolenaar WH, Hla T. SnapShot: Bioactive lysophospholipids. Cell. Jan 20 2012;148(1-2):378-378.e372.
 
Jung B, Obinata H, Galvani S, et al. Flow-regulated endothelial S1P receptor-1 signaling sustains vascular development. Dev Cell. Sep 11 2012;23(3):600-610.
 
Hla T, Galvani S, Rafii S, Nachman R. S1P and the birth of platelets. J Exp Med. Nov 19 2012;209(12):2137-2140.
 
Hla T, Dannenberg AJ. Sphingolipid signaling in metabolic disorders. Cell Metab. Oct 03 2012;16(4):420-434.
 
2011
 
Subbaramaiah K, Howe LR, Bhardwaj P, et al. Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer Prev Res (Phila). Mar 2011;4(3):329-346.
 
Skoura A, Michaud J, Im DS, et al. Sphingosine-1-phosphate receptor-2 function in myeloid cells regulates vascular inflammation and atherosclerosis. Arterioscler Thromb Vasc Biol. Jan 2011;31(1):81-85.
 
Oo ML, Chang SH, Thangada S, et al. Engagement of S1P(1)-degradative mechanisms leads to vascular leak in mice. J Clin Invest. Jun 2011;121(6):2290-2300.
 
Li MH, Hla T, Ferrer F. Sphingolipid modulation of angiogenic factor expression in neuroblastoma. Cancer Prev Res (Phila). Aug 2011;4(8):1325-1332.
 
Hla T, Brinkmann V. Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation. Neurology. Feb 22 2011;76(8 Suppl 3):S3-8.
 
Christoffersen C, Obinata H, Kumaraswamy SB, et al. Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M. Proc Natl Acad Sci U S A. Jun 07 2011;108(23):9613-9618.
 
Chang SH, Hla T. Gene regulation by RNA binding proteins and microRNAs in angiogenesis. Trends Mol Med. Nov 2011;17(11):650-658.
 
 
2010
 
Thangada S, Khanna KM, Blaho VA, et al. Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics. J Exp Med. Jul 05 2010;207(7):1475-1483.
 
Michaud J, Im DS, Hla T. Inhibitory role of sphingosine 1-phosphate receptor 2 in macrophage recruitment during inflammation. J Immunol. Feb 01 2010;184(3):1475-1483.
 
Hla T, Oo ML. Ramping up RANTES in the acute response to arterial injury. J Clin Invest. Jan 2010;120(1):90-92.
 
 
Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH. International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacol Rev. Dec 2010;62(4):579-587.
 
2009
 
ter Braak M, Danneberg K, Lichte K, et al. Galpha(q)-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors. Biochim Biophys Acta. May 2009;1791(5):357-370.
 
Skoura A, Hla T. Lysophospholipid receptors in vertebrate development, physiology, and pathology. J Lipid Res. Apr 2009;50 Suppl:S293-298.
 
Skoura A, Hla T. Regulation of vascular physiology and pathology by the S1P2 receptor subtype. Cardiovasc Res. May 01 2009;82(2):221-228.
 
Li MH, Sanchez T, Yamase H, et al. S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor. Cancer Lett. Apr 18 2009;276(2):171-179.
 
Li MH, Sanchez T, Milne GL, Morrow JD, Hla T, Ferrer F. S1P/S1P2 signaling induces cyclooxygenase-2 expression in Wilms tumor. J Urol. Mar 2009;181(3):1347-1352.
 
Hla T, Im DS. Cell biology. The ABCs of lipophile transport. Science. Feb 13 2009;323(5916):883-884.
 
 
 
Ghosh M, Ai Y, Narko K, Wang Z, Peters JM, Hla T. PPARdelta is pro-tumorigenic in a mouse model of COX-2-induced mammary cancer. Prostaglandins Other Lipid Mediat. Apr 2009;88(3-4):97-100.
 
Ghosh M, Aguila HL, Michaud J, et al. Essential role of the RNA-binding protein HuR in progenitor cell survival in mice. J Clin Invest. Dec 2009;119(12):3530-3543.
 
2008
 
 
Venkataraman K, Lee YM, Michaud J, et al. Vascular endothelium as a contributor of plasma sphingosine 1-phosphate. Circ Res. Mar 28 2008;102(6):669-676.
 
Subbaramaiah K, Hudis C, Chang SH, Hla T, Dannenberg AJ. EP2 and EP4 receptors regulate aromatase expression in human adipocytes and breast cancer cells. Evidence of a BRCA1 and p300 exchange. J Biol Chem. Feb 08 2008;283(6):3433-3444.
 
Sekiguchi M, Iwasaki T, Kitano M, et al. Role of sphingosine 1-phosphate in the pathogenesis of Sjogren's syndrome. J Immunol. Feb 01 2008;180(3):1921-1928.
 
Li MH, Sanchez T, Pappalardo A, Lynch KR, Hla T, Ferrer F. Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2. Mol Cancer Res. Oct 2008;6(10):1649-1656.
 
Hla T, Venkataraman K, Michaud J. The vascular S1P gradient-cellular sources and biological significance. Biochim Biophys Acta. Sep 2008;1781(9):477-482.
 
 
2007
 
Soldi R, Mandinova A, Venkataraman K, et al. Sphingosine kinase 1 is a critical component of the copper-dependent FGF1 export pathway. Exp Cell Res. Sep 10 2007;313(15):3308-3318.
 
Skoura A, Sanchez T, Claffey K, Mandala SM, Proia RL, Hla T. Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina. J Clin Invest. Sep 2007;117(9):2506-2516.
 
Sanchez T, Skoura A, Wu MT, Casserly B, Harrington EO, Hla T. Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN. Arterioscler Thromb Vasc Biol. Jun 2007;27(6):1312-1318.
 
 
Lee YM, Venkataraman K, Hwang SI, Han DK, Hla T. A novel method to quantify sphingosine 1-phosphate by immobilized metal affinity chromatography (IMAC). Prostaglandins Other Lipid Mediat. Nov 2007;84(3-4):154-162.
 
Kono M, Belyantseva IA, Skoura A, et al. Deafness and stria vascularis defects in S1P2 receptor-null mice. J Biol Chem. Apr 06 2007;282(14):10690-10696.
Hla T, Feinmark SJ. A festschrift for J. Martyn Bailey, a biochemist extraordinaire. Prostaglandins Other Lipid Mediat. Feb 2007;83(1-2):154-157.
 
Gonzalez-Cabrera PJ, Hla T, Rosen H. Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics. J Biol Chem. Mar 09 2007;282(10):7254-7264.
 
Ghosh M, Wang H, Ai Y, et al. COX-2 suppresses tissue factor expression via endocannabinoid-directed PPARdelta activation. J Exp Med. Sep 03 2007;204(9):2053-2061.
 
2006
 
Venkataraman K, Thangada S, Michaud J, et al. Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient. Biochem J. Aug 01 2006;397(3):461-471.
 
Thompson B, Ancellin N, Fernandez SM, Hla T, Sha'afi RI. Protein kinase Calpha and sphingosine 1-phosphate-dependent signaling in endothelial cell. Prostaglandins Other Lipid Mediat. Jul 2006;80(1-2):15-27.
 
Subbaramaiah K, Howe LR, Port ER, et al. HER-2/neu status is a determinant of mammary aromatase activity in vivo: evidence for a cyclooxygenase-2-dependent mechanism. Cancer Res. May 15 2006;66(10):5504-5511.
 
Michaud J, Kohno M, Proia RL, Hla T. Normal acute and chronic inflammatory responses in sphingosine kinase 1 knockout mice. FEBS Lett. Aug 21 2006;580(19):4607-4612.
 
 
Lee JF, Ozaki H, Zhan X, Wang E, Hla T, Lee MJ. Sphingosine-1-phosphate signaling regulates lamellipodia localization of cortactin complexes in endothelial cells. Histochem Cell Biol. Sep 2006;126(3):297-304.
 
LaMontagne K, Littlewood-Evans A, Schnell C, et al. Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization. Cancer Res. Jan 01 2006;66(1):221-231.
 
Kohno M, Momoi M, Oo ML, et al. Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Mol Cell Biol. Oct 2006;26(19):7211-7223.
 
 
 
2005
 
Sanchez T, Thangada S, Wu MT, et al. PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc Natl Acad Sci U S A. Mar 22 2005;102(12):4312-4317.
 
Rapaka RS, Hla T, Dey SK. The dawn of lipidomics. Prostaglandins Other Lipid Mediat. Sep 2005;77(1-4):1-3.
 
Narko K, Zweifel B, Trifan O, Ristimaki A, Lane TF, Hla T. COX-2 inhibitors and genetic background reduce mammary tumorigenesis in cyclooxygenase-2 transgenic mice. Prostaglandins Other Lipid Mediat. May 2005;76(1-4):86-94.
 
Li Z, Paik JH, Wang Z, Hla T, Wu D. Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells. Prostaglandins Other Lipid Mediat. May 2005;76(1-4):95-104.
 
Li Z, Dong X, Wang Z, et al. Regulation of PTEN by Rho small GTPases. Nat Cell Biol. Apr 2005;7(4):399-404.
 
Lepley D, Paik JH, Hla T, Ferrer F. The G protein-coupled receptor S1P2 regulates Rho/Rho kinase pathway to inhibit tumor cell migration. Cancer Res. May 01 2005;65(9):3788-3795.
 
 
Howe LR, Chang SH, Tolle KC, et al. HER2/neu-induced mammary tumorigenesis and angiogenesis are reduced in cyclooxygenase-2 knockout mice. Cancer Res. Nov 01 2005;65(21):10113-10119.
 
Hla T. Genomic insights into mediator lipidomics. Prostaglandins Other Lipid Mediat. Sep 2005;77(1-4):197-209.
 
Hla T. Immunology. Dietary factors and immunological consequences. Science. Sep 09 2005;309(5741):1682-1683.
 
Heinonen M, Bono P, Narko K, et al. Cytoplasmic HuR expression is a prognostic factor in invasive ductal breast carcinoma. Cancer Res. Mar 15 2005;65(6):2157-2161.
 
 
Chang SH, Ai Y, Breyer RM, Lane TF, Hla T. The prostaglandin E2 receptor EP2 is required for cyclooxygenase 2-mediated mammary hyperplasia. Cancer Res. Jun 01 2005;65(11):4496-4499.
 
Chae SS, Hla T. Inhibition of gene expression in vivo using multiplex siRNA. Methods Mol Biol. 2005;309:197-203.
 
2004
 
Simmons DL, Botting RM, Hla T. Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. Pharmacol Rev. Sep 2004;56(3):387-437.
 
Sanchez T, Hla T. Structural and functional characteristics of S1P receptors. J Cell Biochem. Aug 01 2004;92(5):913-922.
 
Saba JD, Hla T. Point-counterpoint of sphingosine 1-phosphate metabolism. Circ Res. Apr 02 2004;94(6):724-734.
 
Paik JH, Skoura A, Chae SS, et al. Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization. Genes Dev. Oct 01 2004;18(19):2392-2403.
 
 
Jang BC, Kim DH, Park JW, et al. Induction of cyclooxygenase-2 in macrophages by catalase: role of NF-kappaB and PI3K signaling pathways. Biochem Biophys Res Commun. Apr 02 2004;316(2):398-406.
 
Hla T. Prostaglandins & other lipid mediators: a new phase, a new team. Prostaglandins Other Lipid Mediat. Jan 2004;73(1-2):1-2.
 
Hla T. Physiological and pathological actions of sphingosine 1-phosphate. Semin Cell Dev Biol. Oct 2004;15(5):513-520.
 
Chang SH, Liu CH, Conway R, et al. Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression. Proc Natl Acad Sci U S A. Jan 13 2004;101(2):591-596.
 
Chae SS, Proia RL, Hla T. Constitutive expression of the S1P1 receptor in adult tissues. Prostaglandins Other Lipid Mediat. Jan 2004;73(1-2):141-150.
 
Chae SS, Paik JH, Furneaux H, Hla T. Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference. J Clin Invest. Oct 2004;114(8):1082-1089.
 
Chae SS, Paik JH, Allende ML, Proia RL, Hla T. Regulation of limb development by the sphingosine 1-phosphate receptor S1p1/EDG-1 occurs via the hypoxia/VEGF axis. Dev Biol. Apr 15 2004;268(2):441-447.
 
Brinkmann V, Cyster JG, Hla T. FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. Am J Transplant. Jul 2004;4(7):1019-1025.
 
2003
 
Trifan OC, Hla T. Cyclooxygenase-2 modulates cellular growth and promotes tumorigenesis. J Cell Mol Med. Jul-Sep 2003;7(3):207-222.
 
Sengupta S, Jang BC, Wu MT, Paik JH, Furneaux H, Hla T. The RNA-binding protein HuR regulates the expression of cyclooxygenase-2. J Biol Chem. Jul 04 2003;278(27):25227-25233.
 
Sanchez T, Estrada-Hernandez T, Paik JH, et al. Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability. J Biol Chem. Nov 21 2003;278(47):47281-47290.
 
Ozaki H, Hla T, Lee MJ. Sphingosine-1-phosphate signaling in endothelial activation. J Atheroscler Thromb. 2003;10(3):125-131.
 
 
Jang BC, Munoz-Najar U, Paik JH, Claffey K, Yoshida M, Hla T. Leptomycin B, an inhibitor of the nuclear export receptor CRM1, inhibits COX-2 expression. J Biol Chem. Jan 31 2003;278(5):2773-2776.
 
Inaba T, Sano H, Kawahito Y, et al. Induction of cyclooxygenase-2 in monocyte/macrophage by mucins secreted from colon cancer cells. Proc Natl Acad Sci U S A. Mar 04 2003;100(5):2736-2741.
 
Hla T. Signaling and biological actions of sphingosine 1-phosphate. Pharmacol Res. May 2003;47(5):401-407.
 
Erkinheimo TL, Lassus H, Sivula A, et al. Cytoplasmic HuR expression correlates with poor outcome and with cyclooxygenase 2 expression in serous ovarian carcinoma. Cancer Res. Nov 15 2003;63(22):7591-7594.
 
Donohue PJ, Richards CM, Brown SA, et al. TWEAK is an endothelial cell growth and chemotactic factor that also potentiates FGF-2 and VEGF-A mitogenic activity. Arterioscler Thromb Vasc Biol. Apr 01 2003;23(4):594-600.
 
2002
 
Kluk MJ, Hla T. Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. Biochim Biophys Acta. May 23 2002;1582(1-3):72-80.
 
Chun J, Goetzl EJ, Hla T, et al. International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacol Rev. Jun 2002;54(2):265-269.
 
Bishop-Bailey D, Hla T, Warner TD. Intimal smooth muscle cells as a target for peroxisome proliferator-activated receptor-gamma ligand therapy. Circ Res. Aug 09 2002;91(3):210-217.
 
Bishop-Bailey D, Calatayud S, Warner TD, Hla T, Mitchell JA. Prostaglandins and the regulation of tumor growth. J Environ Pathol Toxicol Oncol. 2002;21(2):93-101.
 
 
2001
 
Tsubouchi Y, Kawahito Y, Kohno M, Inoue K, Hla T, Sano H. Feedback control of the arachidonate cascade in rheumatoid synoviocytes by 15-deoxy-Delta(12,14)-prostaglandin J2. Biochem Biophys Res Commun. May 18 2001;283(4):750-755.
 
 
 
Liu CH, Chang SH, Narko K, et al. Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice. J Biol Chem. May 25 2001;276(21):18563-18569.
 
 
 
Inoue K, Kawahito Y, Tsubouchi Y, et al. Expression of peroxisome proliferator-activated receptor (PPAR)-gamma in human lung cancer. Anticancer Res. Jul-Aug 2001;21(4a):2471-2476.
 
Hla T, Lee MJ, Ancellin N, Paik JH, Kluk MJ. Lysophospholipids--receptor revelations. Science. Nov 30 2001;294(5548):1875-1878.
 
Hla T. Sphingosine 1-phosphate receptors. Prostaglandins Other Lipid Mediat. Apr 2001;64(1-4):135-142.
 
 
Casibang M, Purdom S, Jakowlew S, et al. Prostaglandin E2 and vasoactive intestinal peptide increase vascular endothelial cell growth factor mRNAs in lung cancer cells. Lung Cancer. Feb-Mar 2001;31(2-3):203-212.
 
2000
 
Yoshimura R, Sano H, Masuda C, et al. Expression of cyclooxygenase-2 in prostate carcinoma. Cancer. Aug 01 2000;89(3):589-596.
 
Yamada R, Sano H, Hla T, et al. Selective inhibition of cyclooxygenase-2 with antisense oligodeoxynucleotide restricts induction of rat adjuvant-induced arthritis. Biochem Biophys Res Commun. Mar 16 2000;269(2):415-421.
 
Tsubouchi Y, Sano H, Kawahito Y, et al. Inhibition of human lung cancer cell growth by the peroxisome proliferator-activated receptor-gamma agonists through induction of apoptosis. Biochem Biophys Res Commun. Apr 13 2000;270(2):400-405.
 
Liu Y, Wada R, Yamashita T, et al. Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J Clin Invest. Oct 2000;106(8):951-961.
 
Kawahito Y, Kondo M, Tsubouchi Y, et al. 15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats. J Clin Invest. Jul 2000;106(2):189-197.
 
 
Im DS, Heise CE, Ancellin N, et al. Characterization of a novel sphingosine 1-phosphate receptor, Edg-8. J Biol Chem. May 12 2000;275(19):14281-14286.
 
Hla T, Lee MJ, Ancellin N, et al. Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors. Ann N Y Acad Sci. Apr 2000;905:16-24.
 
Clark RB, Bishop-Bailey D, Estrada-Hernandez T, Hla T, Puddington L, Padula SJ. The nuclear receptor PPAR gamma and immunoregulation: PPAR gamma mediates inhibition of helper T cell responses. J Immunol. Feb 01 2000;164(3):1364-1371.
 
Bishop-Bailey D, Hla T, Warner TD. Bisphenol A diglycidyl ether (BADGE) is a PPARgamma agonist in an ECV304 cell line. Br J Pharmacol. Oct 2000;131(4):651-654.
 
Ancellin N, Hla T. Switching intracellular signaling pathways to study sphingosine 1-phosphate receptors. Ann N Y Acad Sci. Apr 2000;905:260-262.
 
1999
 
Yamada R, Sano H, Hla T, et al. Auranofin inhibits interleukin-1beta-induced transcript of cyclooxygenase-2 on cultured human synoviocytes. Eur J Pharmacol. Nov 26 1999;385(1):71-79.
 
 
Trifan OC, Smith RM, Thompson BD, Hla T. Overexpression of cyclooxygenase-2 induces cell cycle arrest. Evidence for a prostaglandin-independent mechanism. J Biol Chem. Nov 26 1999;274(48):34141-34147.
 
Liu CH, Thangada S, Lee MJ, Van Brocklyn JR, Spiegel S, Hla T. Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1. Mol Biol Cell. Apr 1999;10(4):1179-1190.
 
Lee MJ, Thangada S, Claffey KP, et al. Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. Cell. Oct 29 1999;99(3):301-312.
 
Hla T, Lee MJ, Ancellin N, et al. Sphingosine-1-phosphate: extracellular mediator or intracellular second messenger? Biochem Pharmacol. Jul 15 1999;58(2):201-207.
 
Hla T, Bishop-Bailey D, Liu CH, Schaefers HJ, Trifan OC. Cyclooxygenase-1 and -2 isoenzymes. Int J Biochem Cell Biol. May 1999;31(5):551-557.
 
Bishop-Bailey D, Hla T, Mitchell JA. Cyclo-oxygenase-2 in vascular smooth muscle. Int J Mol Med. Jan 1999;3(1):41-48.
 
 
 
1998
 
 
Lee MJ, Van Brocklyn JR, Thangada S, et al. Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. Science. Mar 06 1998;279(5356):1552-1555.
 
Lee MJ, Thangada S, Liu CH, Thompson BD, Hla T. Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist. J Biol Chem. Aug 21 1998;273(34):22105-22112.
 
Hida T, Leyton J, Makheja AN, et al. Non-small cell lung cancer cycloxygenase activity and proliferation are inhibited by non-steroidal antiinflammatory drugs. Anticancer Res. Mar-Apr 1998;18(2a):775-782.
 
 
1997
 
Narko K, Ristimaki A, MacPhee M, Smith E, Haudenschild CC, Hla T. Tumorigenic transformation of immortalized ECV endothelial cells by cyclooxygenase-1 overexpression. J Biol Chem. Aug 22 1997;272(34):21455-21460.
 
Liu CH, Hla T. The mouse gene for the inducible G-protein-coupled receptor edg-1. Genomics. Jul 01 1997;43(1):15-24.
 
 
 
1996
 
 
 
 
1995
 
Sano H, Kawahito Y, Wilder RL, et al. Expression of cyclooxygenase-1 and -2 in human colorectal cancer. Cancer Res. Sep 01 1995;55(17):3785-3789.
 
Hla T, Jackson AQ, Appleby SB, Maciag T. Characterization of edg-2, a human homologue of the Xenopus maternal transcript G10 from endothelial cells. Biochim Biophys Acta. Jan 25 1995;1260(2):227-229.
 
 
1994
 
Ristimaki A, Garfinkel S, Wessendorf J, Maciag T, Hla T. Induction of cyclooxygenase-2 by interleukin-1 alpha. Evidence for post-transcriptional regulation. J Biol Chem. Apr 22 1994;269(16):11769-11775.
 
Laneuville O, Breuer DK, Dewitt DL, Hla T, Funk CD, Smith WL. Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. Nov 1994;271(2):927-934.
 
 
Appleby SB, Ristimaki A, Neilson K, Narko K, Hla T. Structure of the human cyclo-oxygenase-2 gene. Biochem J. Sep 15 1994;302 ( Pt 3):723-727.
 
1993
 
 
Hla T, Ristimaki A, Appleby S, Barriocanal JG. Cyclooxygenase gene expression in inflammation and angiogenesis. Ann N Y Acad Sci. Nov 30 1993;696:197-204.
 
1992
 
 
Hla T, Neilson K. Human cyclooxygenase-2 cDNA. Proc Natl Acad Sci U S A. Aug 15 1992;89(16):7384-7388.
 
1991
 
 
 
 
1990
 
Smith WL, DeWitt DL, Kraemer SA, et al. Structure-function relationships in sheep, mouse, and human prostaglandin endoperoxide G/H synthases. Adv Prostaglandin Thromboxane Leukot Res. 1990;20:14-21.
 
Maier JA, Hla T, Maciag T. Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells. J Biol Chem. Jul 05 1990;265(19):10805-10808.
 
Imamura T, Engleka K, Zhan X, et al. Recovery of mitogenic activity of a growth factor mutant with a nuclear translocation sequence. Science. Sep 28 1990;249(4976):1567-1570.
 
 
 
1989
 
Goldgaber D, Harris HW, Hla T, et al. Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. Proc Natl Acad Sci U S A. Oct 1989;86(19):7606-7610.
 
1986
 
Hla T, Farrell M, Kumar A, Bailey JM. Isolation of the cDNA for human prostaglandin H synthase. Prostaglandins. Dec 1986;32(6):829-845.
 
1985
 
 
Bailey JM, Muza B, Hla T, Pash J. Role of epidermal growth factor in cyclooxygenase synthesis. Adv Prostaglandin Thromboxane Leukot Res. 1985;15:141-142.
 
1979
 
Hagan KJ, Smith SE, Gyi KM, et al. The reliability of self-administration of dapsone by leprosy patients in Burma. Lepr Rev. Sep 1979;50(3):201-211.