Patterns of sleep restriction and recovery: The inflammatory resolution pathways
The goal of this project is to investigate whether the newly discovered inflammatory resolution pathways are affected by sleep restriction and responsible for slow and/or incomplete inflammatory recovery from sleep restriction.
NIH/NHLBI R01 HL136310 [PI Monika Haack] 04/15/2018-04/14/2023
Mechanisms underlying the blood pressure lowering effect of sleep extension
The goal of the study is to look at the non-pharmalogical intervention of sleep extension and sleep timing and their blood pressure lowering effects. We hypothesize that chronic sleep deficiency is causally related to the development of hypertension and cardiovascular disease via effects on the mechanisms supporting autonomic homeostatic control. We hypothesize further, that correcting sleep deficiency will improve autonomic regulatory control and thereby result in lower BP in hypertensive and pre-hypertensive individuals.
NIH/NHLBI R01 HL125379 [PI Janet Mullington] 08/19/2016-06/30/2021