Pain sensitization and habituation in a model of experimentally-induced insomnia symptoms
The goal of this project is to investigate two processes underlying increased pain vulnerability in the course of repeated exposure to insomnia: (1) Sensitization of the nociceptive system due to a progressive increase of the inflammatory response and (2) Decreased habituation to pain due to a progressive deterioration of the pain-inhibitory response. These two processes will be investigated in a novel model of repeated exposure to experimentally-induced insomnia symptoms. This research is fundamental for the future development of novel strategies targeting specific mechanisms to prevent or reduce pain exacerbated by insomnia.
NIH/NINDS R01 NS091177 [PI Monika Haack] 04/01/2015-03/31/2019
Challenging the inflammatory response system: Are individuals with insomnia more reactive?
Repeating patterns of sleep restriction and recovery – do we get used to it?
The repeated challenge of insufficient sleep: effects on endothelial function
Preventing the inflammatory response to experimentally-induced insomnia symptoms
Does sleep maintenance insomnia lead to stronger activation of stress response systems than sleep onset insomnia?
Aging and the inflammatory, metabolic and autonomic response to sleep loss.
Pain perception and skill learning in primary insomnia and normal sleepers
Sepracor Inc. [PI: Janet M. Mullington] 6/1/2008 - 5/31/2010
Restoring sleep homeostasis to lower BP: a behavioral prevention and treatment approach
[PI: Monika Haack] 7/1/2005 - 6/30/2010