Immune, neuroendocrine, and metabolic functions in insomnia disorder. In: Encyclopedia of Sleep and Circadian Rhythms. 2nd ed. Elsevier ; In Press.Abstract.
Substantial evidence supports that insomnia prospectively increases risks for developing a wide range of diseases, including cardiovascular, metabolic, neurodegenerative, autoimmune, carcinogenic diseases, and pain disorders. The mechanisms underlying increased disease risks in individuals suffering from insomnia are an active area of research and involve dysregulations of multiple biological systems, including immune, neuroendocrine, and metabolic processes. Dysregulations in these physiological domains as they have been observed in insomnia disorder will be reviewed and their potential in mediating increased disease risk will be discussed.