@article {111631,
	title = {Sister cohesion and structural axis components mediate homolog bias of meiotic recombination.},
	journal = {Cell},
	volume = {143},
	number = {6},
	year = {2010},
	month = {2010 Dec 10},
	pages = {924-37},
	abstract = {Meiotic double-strand break (DSB)-initiated recombination must occur between homologous maternal and paternal chromosomes ("homolog bias"), even though sister chromatids are present. Through physical recombination analyses, we show that sister cohesion, normally mediated by meiotic cohesin Rec8, promotes "sister bias"; that meiosis-specific axis components Red1/Mek1kinase counteract this effect, thereby satisfying an essential precondition for homolog bias; and that other components, probably recombinosome-related, directly ensure homolog partner selection. Later, Rec8 acts positively to ensure maintenance of bias. These complexities mirror opposing dictates for global sister cohesion versus local separation and differentiation of sisters at recombination sites. Our findings support DSB formation within axis-tethered recombinosomes containing both sisters and ensuing programmed sequential release of "first" and "second" DSB ends. First-end release would create a homology-searching "tentacle." Rec8 and Red1/Mek1 also independently license recombinational progression and abundantly localize to different domains. These domains could comprise complementary environments that integrate inputs from DSB repair and mitotic chromosome morphogenesis into the complete meiotic program.},
	keywords = {Chromosomal Proteins, Non-Histone, Chromosomes, Fungal, Crossing Over, Genetic, DNA Breaks, Double-Stranded, MAP Kinase Kinase 1, Meiosis, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Sister Chromatid Exchange},
	issn = {1097-4172},
	doi = {10.1016/j.cell.2010.11.015},
	author = {Kim, Keun P and Weiner, Beth M and Zhang, Liangran and Jordan, Amy and Dekker, Job and Kleckner, Nancy}
}
