TBResisit Project

TBResist is a Consortium of groups looking at the genome sequence data of MDR, XDR, and TDR TB strains has come together to carry out a joint analysis of their data in order to understand and find a way to counteract genomic drug resistance. The consortium will initially focus on strains that are well characterized clinically in terms of patient outcome (cure, treatment failure, death and when possible the presence or absence of co-HIV infection). The focus will begin on South Africa with the goal of expanding the scope to incorporate diverse geographies. The initial cohorts to work with have been identified as PROX, PYM One, PYM Two, CDC PETTS Study, and South Africa Medical Research Council.


The consortium will have the following main objectives:

1. Use collective data to define and understand the genomic foundations of    TB drug resistance.

2. Use new found knowledge to develop a predictive analytics platform and service to support patient treatment

3. Provide molecular epidemiology information

4. Work toward the development of new diagnostics and vaccines

5. Aid in drug discovery

The TBResist project technical and informatics objectives are*:

1. Create a portal to adverise the TBResist initiative, allow interested collaborators to
submit an application to participate, provide metadata describing cohorts to be
considered for inclusion, and track the work flow for specimens and data processing
2. Create a pre-analytics data warehouse that contains all data from all cohorts
3. Create an analytic data mart that contains data that has undergone quality assurance
processing and is available for analytic work
4. Provide collaborators access to the IBM BDM platform
        a. End users can submit sequences for predictive analytics
        b. Scientists can develop and integrate predictive analytics to the BDM
             thus making them available for use to the greater clinical and research
5. To combine the different engines into a predictive system and make it publicly available
on the web, with a sponsor based exploitation schema
6. Deliver molecular epidemiology services for public health programs that are interested
in understanding the patterns of spread of DRTB
7. Render genomic and bioinformatics data available to researchers interested in drug
development and new diagnostic development
*All of the above services will be delivered with appropriate levels of security and will
ensure protection of intellectual property as outlined in the partner agreement