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Dr. Podell

Dr. Brendan Podell recipient of the 2017 Zoetis Research Excellence Award

January 20, 2018

TBRU LIMAA's own Dr. Brendan Podell received the 2017 Zoetis Research Excellence Award from the College of Veterinary Medicine and Biomedical Science at the Colorado State University. Global animal health company Zoetis sponsors Research Day and the Research Excellence Award. Dr. Podell kicked off the 2018 Research Day with a keynote address, “The pathologic intersection of tuberculosis and metabolic disease” on Saturday, January 20. Read the full story by Mary Guiden at ...

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NIAID awards Dr. Brendan Podell,TBRU LIMAA investigator at CSU, funding to study the impact of viatmin A deficiency on TB progression and immunity

October 23, 2017

In recent prospective studies among human cohorts in Lima, Peru, led by TBRU LIMAA co-PI Dr. Megan Murray, vitamin A was identified as a substantial risk factor for progression to active TB among exposed household contacts, linking the risk of TB progression and vitamin A deficiency. Dr. Podell proposed and received funding for a pilot study to further study the immune mechanisms and impact on TB outcome of vitamin A deficiency in a guinea pig model. Funding for the study was obtained through the NIAID’s supplemental funding mechanism that provides support for high priority research...

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Peru: Study Aims to Reveal How TB Spreads

March 25, 2015

Scientists have long debated the dynamics of how tuberculosis spreads in people, including whether MDR-TB is as likely to spread as drug-sensitive TB. The epidemiologists behind this study hope that answering the question will better equip public health professionals to stop tuberculosis in all its forms. Researchers have already published some results of the study and expect more to come out this year, including the relative transmissibility of MDR-TB and drug-sensitive TB.

“When we designed this study almost 10 years ago, no one had actually measured TB transmission in...

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Terpene Nucleosides as Specific Diagnostic Markers of Tuberculosis

March 20, 2015

David Young and a team within Branch Moody’s lab at the Brigham and Women’s Hospital together with collaborators at the KwaZulu-Nata Research Institute for Tuberculosis & HIV in South Africa recently established a structure of the previously unknown molecule, N6-tuberculosinyladenosine (N6-TbAd), yielded from an in vivo biotransformed 1-TbAd molecule. 

In the paper recently accepted at Chemistry and Biology, the group demonstrates that this recently identified compound, 1-tuberculosinyladenosine (1-TbAd), accumulates to comprise greater than 1 percent...

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NIH funds new HMS, Brigham and Women's Hospital, and Partners In Health research unit

March 3, 2015

An ongoing collaboration between Harvard Medical School, Brigham and Women’s Hospital and a community health program in Lima, Peru, has provided an exceptional platform both for carrying out complex biomedical research in a resource-poor setting and for improving the delivery of health care to an under-served population.

In the latest chapter of that relationship, Brigham and Women’s, Harvard Medical School and Partners in...

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Anti-diabetic drug springs new hope for tuberculosis patients

December 17, 2014

A more effective treatment for tuberculosis (TB) could soon be available as scientists have discovered that Metformin (MET), a drug for treating diabetes, can also be used to boost the efficacy of TB medication without inducing drug resistance. 

The team of scientists began searching for drugs that could control Mtb replication indirectly. They screened FDA-approved drugs and identified MET, an old anti-...

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