A Self-Killing Rabies Virus That Leaves a Trace on the DNA

Citation:

Menegas, W., Uchida, N., & Watabe-Uchida, M. (2017). A Self-Killing Rabies Virus That Leaves a Trace on the DNA. Trends Neurosci. , 40 (10), 589-591.

Abstract:

Although modified rabies viruses have emerged as a powerful tool for tracing the inputs to genetically defined populations of neurons, the toxicity of the virus has limited its utility. A recent study employed a self-inactivating rabies (SiR) virus that enables recording or manipulation of targeted neurons for months.

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