Postdoctoral positions are available in the laboratory of Zhe Li, PhD, Division of Genetics, Brigham & Women's Hospital and Harvard Medical School. The Li Laboratory is interested in elucidating how cancers develop from their cells of origin, by using mouse models and organoid culture systems, with a focus on hormone-related cancers (i.e., breast, ovarian/fallopian tube, and prostate cancers). The lab studies how genetic, epigenetic, and environmental factors, as well as their interactions, contribute to epithelial cancer initiation, progression and metastasis. Potential research projects include: 1) Models and mechanisms of breast cancer development induced by BRCA1-loss or RUNX1-loss. 2) Epigenetic regulation and immune mechanism in breast cancer metastasis. 3) Regulation of mammary (or fallopian tube, or prostate) epithelial cells by environmental factors (e.g., immune cells, hormones, stromal cells) during cancer initiation and progression.
The Li Laboratory is particularly interested in the intersection of immunology, developmental biology, stem cell biology, and cancer biology. Applicants are expected to have completed their PhD and/or MD degree and be highly motivated for a career in academic biomedical research. Previous experience with immunology, mammary gland biology, stem cell and developmental biology, single cell analysis, or mouse models of human cancer is preferred. Application (including cover letter, CV, and contact information of three referees) and inquiries should be submitted by e-mail to Zhe Li, PhD (firstname.lastname@example.org).