@article {1634925,
	title = {Binding of TMPRSS2-ERG to BAF Chromatin Remodeling Complexes Mediates Prostate Oncogenesis},
	journal = {Mol Cell},
	volume = {71},
	number = {4},
	year = {2018},
	month = {2018 Aug 16},
	pages = {554-566.e7},
	abstract = {Chromosomal rearrangements resulting in the fusion of TMPRSS2, an androgen-regulated gene, and the ETS family transcription factor ERG occur in over half of prostate cancers. However, the mechanism by which ERG promotes oncogenic gene expression and proliferation remains incompletely understood. Here, we identify a binding interaction between ERG and the mammalian SWI/SNF (BAF) ATP-dependent chromatin remodeling complex, which is conserved among other oncogenic ETS factors, including ETV1, ETV4, and ETV5. We find that ERG drives genome-wide retargeting of BAF complexes in a manner dependent on binding of ERG to the ETS DNA motif. Moreover, ERG requires intact BAF complexes for chromatin occupancy and BAF complex ATPase activity for target gene regulation. In a prostate organoid model, BAF complexes are required for ERG-mediated basal-to-luminal transition, a hallmark of ERG activity in prostate cancer. These observations suggest a fundamental interdependence between ETS transcription factors and BAF chromatin remodeling complexes in cancer.},
	keywords = {Adenovirus E1A Proteins, Animals, Binding Sites, Carcinogenesis, Cell Line, Tumor, Cell Proliferation, Chromatin, Chromatin Assembly and Disassembly, DNA, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, HEK293 Cells, Humans, Male, Mice, Transgenic, Nuclear Proteins, Oncogene Proteins, Fusion, Organoids, Prostate, Prostatic Neoplasms, Protein Binding, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-ets, Serine Endopeptidases, Signal Transduction, Transcription Factors, Transcriptional Regulator ERG},
	issn = {1097-4164},
	doi = {10.1016/j.molcel.2018.06.040},
	author = {Sandoval, Gabriel J and Pulice, John L and Pakula, Hubert and Schenone, Monica and Takeda, David Y and Pop, Marius and Boulay, Gaylor and Williamson, Kaylyn E and McBride, Matthew J and Pan, Joshua and St Pierre, Roodolph and Hartman, Emily and Garraway, Levi A and Carr, Steven A and Rivera, Miguel N and Li, Zhe and Ronco, Lucienne and Hahn, William C and Kadoch, Cigall}
}
