@article {1634931,
	title = {A Long-Lived Luminal Subpopulation Enriched with Alveolar Progenitors Serves as Cellular Origin of Heterogeneous Mammary Tumors},
	journal = {Stem Cell Reports},
	volume = {5},
	number = {1},
	year = {2015},
	month = {2015 Jul 14},
	pages = {60-74},
	abstract = {It has been shown that the mammary luminal lineage could be maintained by luminal stem cells or long-lived progenitors, but their identity and role in breast cancer remain largely elusive. By lineage analysis using Wap-Cre mice, we found that, in nulliparous females, mammary epithelial cells (MECs) genetically marked by Wap-Cre represented a subpopulation of CD61+ luminal progenitors independent of ovarian hormones for their maintenance. Using a pulse-chase lineage-tracing approach based on Wap-Cre adenovirus (Ad-Wap-Cre), we found that Ad-Wap-Cre-marked nulliparous MECs were enriched with CD61+ alveolar progenitors (APs) that gave rise to CD61- alveolar luminal cells during pregnancy/lactation and could maintain themselves long term. When transformed by different oncogenes, they could serve as cells of origin of heterogeneous mammary tumors. Thus, our study revealed a type of long-lived AP within the luminal lineage that may serve as the cellular origin of multiple breast cancer subtypes.},
	keywords = {Animals, Breast Neoplasms, Cell Lineage, Epithelial Cells, Female, Humans, Integrin beta3, Mammary Glands, Animal, Mice, Pregnancy, Stem Cells},
	issn = {2213-6711},
	doi = {10.1016/j.stemcr.2015.05.014},
	author = {Tao, Luwei and van Bragt, Maaike P A and Li, Zhe}
}
