Inward-facing structure of transition metal transporter

Our group studies the Nramp family of transition metal transporters, and recently determined this inward-facing structure
Clustered protocadherins involved in neuronal patterning form antiparallel dimers

We study the evolution, structure and assembly of clustered protocadherins, which are involved in neuronal self avoidance.
We use sequence coevolution analyses in our studies

Our recent BBA Biomembranes review highlights how these analyses are powerful tools in studies of membrane proteins
Gaudet Lab Members
Conformations of an Nramp-family transition metal transporter

Our new structures illustrate the three principal conformations of an Nramp transporter.

Lab News!

Aaron's JBC paper on role of TM6b

January 6, 2020

in Nramp conformations is now online!

Our research featured in Commentary from Gary Rudnick

November 5, 2019

on Aaron's recent JPG paper! Read it here.

Aaron's JGP paper on Nramp mechanism

October 16, 2019

roles of protons, metal ion type, and membrane potential. See paper and summary for more!

Elizabeth awarded one of five Aramont Fund Fellowships!

October 11, 2019

to support her work on protocadherins! Details here and here.

Sri's preprint on bioRxiv!

October 8, 2019

on evolvability of ABC transporter substrate selectivity. Find it here.

Nicotinamide N-Methyltransferase (NNMT) structure by Elizabeth!

October 7, 2019

with high-affinity alkynyl bisubstrate inhibitor, collaboration with Rocco Policarpo in Shair lab, out in JMedChem!

Aaron's new manuscript on bioRxiv!

October 3, 2019

on the role of TM6b in metal transport by Nramp. Read more here!

Sri's review on ABC exporters is out!

August 26, 2019

In NSMB - read more their structure, energetics and pharmacology.

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