Inward-facing structure of transition metal transporter

Our group studies the Nramp family of transition metal transporters, and recently determined this inward-facing structure
Clustered protocadherins involved in neuronal patterning form antiparallel dimers

We study the evolution, structure and assembly of clustered protocadherins, which are involved in neuronal self avoidance.
We use sequence coevolution analyses in our studies

Our recent BBA Biomembranes review highlights how these analyses are powerful tools in studies of membrane proteins
Gaudet Lab Members
Conformations of an Nramp-family transition metal transporter

Our new structures illustrate the three principal conformations of an Nramp transporter.

Lab News!

Sri's paper is out at Current Biology

April 15, 2020

On the evolvability of ABC transporter substrate selectivity - find it here and read more here.

New collaborative paper on peripheral neuropathy-causing JAG1 mutations

February 18, 2020

in The Journal of Clinical Investivation, with the Sumner group at JHU!

Aaron Bozzi wins the graduate student Cranefield Award!

February 16, 2020

From the SGP, for best JGP paper in 2019

Elizabeth is profiled on the MCB Dept website!

February 14, 2020

Read more here.

Aaron's JBC paper on role of TM6b

January 6, 2020

in Nramp conformations is now online!

Our research featured in Commentary from Gary Rudnick

November 5, 2019

on Aaron's recent JPG paper! Read it here.

Aaron's JGP paper on Nramp mechanism

October 16, 2019

roles of protons, metal ion type, and membrane potential. See paper and summary for more!

Elizabeth awarded one of five Aramont Fund Fellowships!

October 11, 2019

to support her work on protocadherins! Details here and here.

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