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Gaudet Lab
Department of Molecular and Cellular Biology
Harvard University

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  • nramp_980_550

    Inward-facing structure of transition metal transporter

    Our group studies the Nramp family of transition metal transporters, and recently determined this inward-facing structure

  • pic1

    Clustered protocadherins involved in neuronal patterning form antiparallel dimers

    We study the evolution, structure and assembly of clustered protocadherins, which are involved in neuronal self avoidance.

  • Our recent BBA Biomembranes review highlights how these analyses are powerful tools in studies of membrane proteins

    We use sequence coevolution analyses in our studies

    Our recent BBA Biomembranes review highlights how these analyses are powerful tools in studies of membrane proteins

  • Gaudet Lab

    Gaudet Lab Members

  • Nramp Conformations

    Conformations of an Nramp-family transition metal transporter

    Our new structures illustrate the three principal conformations of an Nramp transporter.

Lab News!

Our research featured in Commentary from Gary Rudnick

November 5, 2019
on Aaron's recent JPG paper! Read it here.

Aaron's JGP paper on Nramp mechanism

October 16, 2019
roles of protons, metal ion type, and membrane potential. See paper and summary for more!

Elizabeth awarded one of five Aramont Fund Fellowships!

October 11, 2019
to support her work on protocadherins! Details here and here.

Sri's preprint on bioRxiv!

October 8, 2019
on evolvability of ABC transporter substrate selectivity. Find it here.

Nicotinamide N-Methyltransferase (NNMT) structure by Elizabeth!

October 7, 2019

 

with high-affinity alkynyl bisubstrate inhibitor, collaboration with Rocco Policarpo in Shair lab, out in JMedChem!

Aaron's new manuscript on bioRxiv!

October 3, 2019
on the role of TM6b in metal transport by Nramp. Read more here!

Sri's review on ABC exporters is out!

August 26, 2019
In NSMB - read more their structure, energetics and pharmacology.

Jack's paper on protocadherin interaction selectivity

August 26, 2019
is out in PNAS. Read more here.
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