Inward-facing structure of transition metal transporter

Our group studies the Nramp family of transition metal transporters, and recently determined this inward-facing structure
Clustered protocadherins involved in neuronal patterning form antiparallel dimers

We study the evolution, structure and assembly of clustered protocadherins, which are involved in neuronal self avoidance.
We use sequence coevolution analyses in our studies

Our recent BBA Biomembranes review highlights how these analyses are powerful tools in studies of membrane proteins
Gaudet Lab Members
Conformations of an Nramp-family transition metal transporter

Our new structures illustrate the three principal conformations of an Nramp transporter.

Lab News!

Sri's review on ABC exporters is out!

August 26, 2019

In NSMB - read more their structure, energetics and pharmacology.

Jack's paper on protocadherin interaction selectivity

August 26, 2019

is out in PNAS. Read more here.

Congrats to new HHMI Gilliam Fellow José Velilla!

July 31, 2019

Read more about the program here.

Welcome to Cambridge PRISE student Femke Ahlers!

June 18, 2019

Crossing the Atlantic to join our lab for the summer.

Welcome to SROH student Arianna Broad!

June 10, 2019

Joining us for the summer from Florida State University.

Welcome to postbac student Michael Gutierrez!

June 1, 2019

Joining us after recently graduating from Boston College. And thanks to NIGMS for diversity supplement funding!

Brenda Chiang is graduating!

May 30, 2019

Congratulations to senior thesis writer Brenda! Today is Commencement Day!

Rachelle named HGWISE Mentor of the Year!

May 24, 2019

Congratulations Rachelle - see more on the award here!

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