Inward-facing structure of transition metal transporter

Our group studies the Nramp family of transition metal transporters, and recently determined this inward-facing structure
Clustered protocadherins involved in neuronal patterning form antiparallel dimers

We study the evolution, structure and assembly of clustered protocadherins, which are involved in neuronal self avoidance.
We use sequence coevolution analyses in our studies

Our recent BBA Biomembranes review highlights how these analyses are powerful tools in studies of membrane proteins
Gaudet Lab Members
Conformations of an Nramp-family transition metal transporter

Our new structures illustrate the three principal conformations of an Nramp transporter.

Lab News!

Aaron and Christina's paper on Nramp conformations

February 8, 2019

is now out in eLife, identifying substrate pathways. Summary here!

Rocio and Jeff's paper on frog toxins

December 27, 2018

and their effect on bacterial channels, out in JGP. Collaboration with the French Lab in Calgary!

Jack and Anna's manuscript out in bioRxiv

December 11, 2018

on clustered protocadherin specificity - collaboration with Marks Lab!

José's manuscript on new TRPV4 disease mutant

December 11, 2018

out in bioRxiv - collaboration with the Gupta lab

Elizabeth and José win teaching awards!

October 20, 2018

Graduate students Elizabeth and José both received Certificates of Distinction and Excellence (Q awards) for their outstanding teaching in MCB 65 in spring 2018!

Former postdoc Ute Hellmich’s paper is out now in Structure!

October 3, 2018

On the interaction of PACSINs with TRPV4.

Welcome to Unice Yoo!

September 19, 2018

joining the lab as an undergraduate researcher!

Summer Interns Gain Research Experience and Forge Friendships through SROH Program

September 10, 2018

Gaudet Lab Summer Intern on SROH Program

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